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Incidence, Time Trends, and Predictors of Intracranial Hemorrhage During Long-Term Follow-up After Acute Myocardial Infarction Coronary Heart Disease
Conclusion The 1-year incidence of ICH after AMI remained stable, at 0.35%, over the study period. Advanced age, decreased renal function, and previous ischemic or hemorrhagic stroke are predictive of increased ICH risk.
Source: JAHA:Journal of the American Heart Association - December 11, 2015 Category: Cardiology Authors: Graipe, A., Binsell-Gerdin, E., Soderstrom, L., Mooe, T. Tags: Coronary Heart Disease Source Type: research

Incremental Value of the CRUSADE, ACUITY, and HAS-BLED Risk Scores for the Prediction of Hemorrhagic Events After Coronary Stent Implantation in Patients Undergoing Long or Short Duration of Dual Antiplatelet Therapy Coronary Heart Disease
Conclusions Our analysis suggests that the CRUSADE score predicts major bleeding similarly to ACUITY and better than HAS BLED in an all-comer population with percutaneous coronary intervention and potentially identifies patients at higher risk of hemorrhagic complications when treated with a long-term dual antiplatelet therapy regimen. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00611286.
Source: JAHA:Journal of the American Heart Association - December 7, 2015 Category: Cardiology Authors: Costa, F., Tijssen, J. G., Ariotti, S., Giatti, S., Moscarella, E., Guastaroba, P., De Palma, R., Ando, G., Oreto, G., Zijlstra, F., Valgimigli, M. Tags: Coronary Heart Disease Source Type: research

Effect Modification of Long-Term Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women Epidemiology
Conclusions In this nationwide cohort, women with diabetes were identified as the subpopulation most sensitive to the adverse cardiovascular health effects of PM.
Source: JAHA:Journal of the American Heart Association - November 25, 2015 Category: Cardiology Authors: Hart, J. E., Puett, R. C., Rexrode, K. M., Albert, C. M., Laden, F. Tags: Epidemiology Source Type: research

Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review Coronary Heart Disease
Conclusions Several frequently used PPIs previously thought to be safe for concomitant use with clopidogrel were associated with greater risk of adverse cardiovascular events. Although the data are observational, they highlight the need for randomized controlled trials to evaluate the safety of concomitant PPI and clopidogrel use in patients with coronary artery disease.
Source: JAHA:Journal of the American Heart Association - October 29, 2015 Category: Cardiology Authors: Sherwood, M. W., Melloni, C., Jones, W. S., Washam, J. B., Hasselblad, V., Dolor, R. J. Tags: Coronary Heart Disease Source Type: research

Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control Epidemiology
Conclusions Modest population-wide shifts in systolic blood pressure could have a substantial impact on cardiovascular disease incidence and should be developed in parallel with interventions targeting populations with blood pressure above goal.
Source: JAHA:Journal of the American Heart Association - October 27, 2015 Category: Cardiology Authors: Hardy, S. T., Loehr, L. R., Butler, K. R., Chakladar, S., Chang, P. P., Folsom, A. R., Heiss, G., MacLehose, R. F., Matsushita, K., Avery, C. L. Tags: Epidemiology Source Type: research

Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and Chronic Obstructive Pulmonary Disease: An Analysis From the Platelet Inhibition and Patient Outcomes (PLATO) Trial Coronary Heart Disease
Conclusions In this post-hoc analysis, COPD patients experienced high rates of ischemic events. Ticagrelor versus clopidogrel reduced and substantially decreased the absolute risk of ischemic events (5.8%) in COPD patients, without increasing overall major bleeding events. The benefit-risk profile supports the use of ticagrelor in patients with ACS and concomitant COPD. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00391872.
Source: JAHA:Journal of the American Heart Association - October 9, 2015 Category: Cardiology Authors: Andell, P., James, S. K., Cannon, C. P., Cyr, D. D., Himmelmann, A., Husted, S., Keltai, M., Koul, S., Santoso, A., Steg, P. G., Storey, R. F., Wallentin, L., Erlinge, D., the PLATO Investigators Tags: Coronary Heart Disease Source Type: research

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study Vascular Medicine
Conclusions Aortic root dilatation is associated with high diastolic blood pressure, high stroke volume, central fat distribution, and inflammatory status. In contrast, at a given diastolic blood pressure and stroke volume, aortic root dilatation is associated with lower pulse pressure and systolic blood pressure.
Source: JAHA:Journal of the American Heart Association - September 28, 2015 Category: Cardiology Authors: de Simone, G., Roman, M. J., De Marco, M., Bella, J. N., Izzo, R., Lee, E. T., Devereux, R. B. Tags: Vascular Medicine Source Type: research

Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study Coronary Heart Disease
Conclusions Novel risk factors are superior to traditional risk factors for predicting 5-year risk of secondary events in patients with stable CHD.
Source: JAHA:Journal of the American Heart Association - July 6, 2015 Category: Cardiology Authors: Beatty, A. L., Ku, I. A., Bibbins-Domingo, K., Christenson, R. H., DeFilippi, C. R., Ganz, P., Ix, J. H., Lloyd-Jones, D., Omland, T., Sabatine, M. S., Schiller, N. B., Shlipak, M. G., Skali, H., Takeuchi, M., Vittinghoff, E., Whooley, M. A. Tags: Coronary Heart Disease Source Type: research

Risk of Incident Coronary Heart Disease Events in Men Compared to Women by Menopause Type and Race Epidemiology
Conclusions Sex differences in the risk of incident CHD events were larger among whites than blacks and varied by type of menopause. Women consistently had a lower risk of incident CHD death than men, but the magnitude of sex differences was greater in whites than blacks for nonfatal events, regardless of menopause type.
Source: JAHA:Journal of the American Heart Association - July 1, 2015 Category: Cardiology Authors: Kim, C., Cushman, M., Khodneva, Y., Lisabeth, L. D., Judd, S., Kleindorfer, D. O., Howard, V. J., Safford, M. M. Tags: Epidemiology Source Type: research

Meta-Analysis of Intracranial Hemorrhage in Acute Coronary Syndromes: Incidence, Predictors, and Clinical Outcomes Coronary Heart Disease
Conclusions In patients with NSTE ACS enrolled in recent clinical trials of antithrombotic therapies, ICH was uncommon. Patients with older age, prior transient ischemic attack/stroke, higher systolic blood pressure, or larger number of antithrombotic agents were at increased risk. One-third of patients with ICH died. These data may be useful to trialists and data and safety monitoring committees for trial conduct and monitoring. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifiers: TRACER: NCT00527943, PLATO: NCT00391872, APPRAISE-2: NCT00831441, TRILOGY ACS: NCT00699998.
Source: JAHA:Journal of the American Heart Association - June 18, 2015 Category: Cardiology Authors: Mahaffey, K. W., Hager, R., Wojdyla, D., White, H. D., Armstrong, P. W., Alexander, J. H., Tricoci, P., Lopes, R. D., Ohman, E. M., Roe, M. T., Harrington, R. A., Wallentin, L. Tags: Coronary Heart Disease Source Type: research

Asymmetric Dimethylarginine and Cardiovascular Risk: Systematic Review and Meta-Analysis of 22 Prospective Studies Epidemiology
Conclusions Available prospective studies suggest associations between circulating ADMA concentration and CVD outcomes under a broad range of circumstances. Further research is needed to better clarify these associations, particularly in large general population studies.
Source: JAHA:Journal of the American Heart Association - May 28, 2015 Category: Cardiology Authors: Willeit, P., Freitag, D. F., Laukkanen, J. A., Chowdhury, S., Gobin, R., Mayr, M., Di Angelantonio, E., Chowdhury, R. Tags: Epidemiology Source Type: research

Geographic Variations in Cardiovascular Health in the United States: Contributions of State- and Individual-Level Factors Epidemiology
Conclusions There is significant state-level variation in poor CVH that is partly explained by individual- and state-level factors. Additional longitudinal research is warranted to examine the influence of state-level policies and food and physical activity environments on poor CVH.
Source: JAHA:Journal of the American Heart Association - May 27, 2015 Category: Cardiology Authors: Gebreab, S. Y., Davis, S. K., Symanzik, J., Mensah, G. A., Gibbons, G. H., Diez-Roux, A. V. Tags: Epidemiology Source Type: research

Race and Ethnicity, Obesity, Metabolic Health, and Risk of Cardiovascular Disease in Postmenopausal Women Epidemiology
Conclusions Metabolic abnormalities appeared to convey more cardiovascular risk among black women.
Source: JAHA:Journal of the American Heart Association - May 20, 2015 Category: Cardiology Authors: Schmiegelow, M. D., Hedlin, H., Mackey, R. H., Martin, L. W., Vitolins, M. Z., Stefanick, M. L., Perez, M. V., Allison, M., Hlatky, M. A. Tags: Epidemiology Source Type: research

Patient Outcomes According to Adherence to Treatment Guidelines for Rhythm Control of Atrial Fibrillation Coronary Heart Disease
Conclusions Adherence to published guidelines in the antiarrhythmic management of AF is associated with improved patient outcomes.
Source: JAHA:Journal of the American Heart Association - April 6, 2015 Category: Cardiology Authors: Qin, D., Leef, G., Alam, M. B., Rattan, R., Munir, M. B., Patel, D., Khattak, F., Vaghasia, N., Adelstein, E., Jain, S. K., Saba, S. Tags: Coronary Heart Disease Source Type: research

Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States Coronary Heart Disease
Conclusions In patients with prior MI or PAD who have not had a previous stroke or TIA, vorapaxar added to standard therapy is effective for long-term secondary prevention of thrombotic CV events, while increasing moderate or severe bleeding. Clinical Trial Registration URL: clinicaltrials.gov Unique Identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - March 19, 2015 Category: Cardiology Authors: Magnani, G., Bonaca, M. P., Braunwald, E., Dalby, A. J., Fox, K. A. A., Murphy, S. A., Nicolau, J. C., Oude Ophuis, T., Scirica, B. M., Spinar, J., Theroux, P., Morrow, D. A. Tags: Coronary Heart Disease Source Type: research

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