Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review Coronary Heart Disease

Conclusions Several frequently used PPIs previously thought to be safe for concomitant use with clopidogrel were associated with greater risk of adverse cardiovascular events. Although the data are observational, they highlight the need for randomized controlled trials to evaluate the safety of concomitant PPI and clopidogrel use in patients with coronary artery disease.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Coronary Heart Disease Source Type: research

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ConclusionsOlder adults with migraine are at increased risk for ischemic stroke. The risk for ischemic stroke among older adults with migraine may differ by migraine medication classes.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
SummaryBackgroundThe influenza season 2017 –2018 of the northern hemisphere was the highest since 2001 and was caused predominantly by influenza B virus.MethodsWe performed a  retrospective analysis of all patients in a university hospital in northern Germany with laboratory-confirmed influenza during the winter season 2017–2018 and analyzed underlying conditions, complications, and outcome.ResultsA  total of 272 cases of influenza were diagnosed: 70 influenza A (25.7%), 201 influenza B (73.9%), and 1 co-infection. Of 182 adults, 145 were hospitalized, 73 developed p...
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. Linking Particulate Air Pollution and Dementia in a Small Region of the US It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Environ Sci Pollut Res Int. 2021 Aug 6. doi: 10.1007/s11356-021-15732-2. Online ahead of print.ABSTRACTPrevious studies have determined the effects of exposure to certain heavy metals on cardiovascular disease (CVD); however, the association between cadmium exposure and CVD in adults remains unclear. The relationship between serum levels of cadmium and the risk of CVD was studied by analyzing available data from 38,223 different participants of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. After adjusting for all covariates, we found that higher serum cadmium concentrations were positivel...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research
Conclusion: Among individuals with obesity, the weight-loss group had a lower risk of coronary heart disease but not of stroke. Weight gain was associated with increased risk of CVD across BMI groups. See video abstract at,
Source: Epidemiology - Category: Epidemiology Tags: Chronic Diseases Source Type: research
CONCLUSION: Higher SU levels were associated with an increased risk for sudden cardiac death but not with incident CHD.PMID:34329187 | DOI:10.3899/jrheum.210139
Source: Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
CONCLUSION: Higher serum urate levels were associated with an increased risk for sudden cardiac death but not with incident CHD.PMID:34329187 | DOI:10.3899/jrheum.210139
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
We examined existing evidence of the association between SDOH —organized into 6 domains, including economic stability, education, food, neighborhood and physical environment, healthcare system, and community and social context—and CVD. Greater social adversity, defined by adverse SDOH, was linked to higher burden of CVD risk factors and poor outcomes, such as stroke, myocardial infarction (MI), coronary heart disease, heart failure, and mortality. Conversely, favorable social conditions had protective effects on CVD.Upstream SDOH interact across domains to produce cumulativedownstream effects on CV health, via ...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Barton et al's1 article studies cardiovascular risk in a cohort of individuals with a spinal cord injury (SCI). As the authors noted, the Framingham Risk Score (FRS) was derived to identify risk factors for cardiovascular disease. It is important to note, however, that the outcome measure for this risk score is defined as a “composite of coronary heart disease (coronary death, myocardial infarction, coronary insufficiency, and angina), cerebrovascular events (including ischemic stroke, hemorrhagic stoke, and transient ischemic attack), peripheral artery disease (intermittent claudication), and heart failure.”2 ...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Letter to the Editor Source Type: research
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