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Atrial Fibrillation Patients Treated With Long-Term Warfarin Anticoagulation Have Higher Rates of All Dementia Types Compared With Patients Receiving Long-Term Warfarin for Other Indications Cardiovascular Surgery
Conclusions The presence of AF significantly increases risk of dementia, including Alzheimer's disease, compared with matched patients receiving warfarin anticoagulation for other reasons. Quality of anticoagulation management remains an important risk factor for dementia in all patients.
Source: JAHA:Journal of the American Heart Association - July 10, 2016 Category: Cardiology Authors: Bunch, T. J., May, H. T., Bair, T. L., Crandall, B. G., Cutler, M. J., Day, J. D., Jacobs, V., Mallender, C., Osborn, J. S., Stevens, S. M., Weiss, J. P., Woller, S. C. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Cardiovascular Surgery Source Type: research

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans Stroke
Conclusions The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.
Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Hattori, Y., Enmi, J.-i., Iguchi, S., Saito, S., Yamamoto, Y., Tsuji, M., Nagatsuka, K., Kalaria, R. N., Iida, H., Ihara, M. Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Cognitive Impairment, Atherosclerosis, Stenosis Source Type: research

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives Imaging
Conclusions N-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Vilar-Bergua, A., Riba-Llena, I., Vanhooren, V., Dewaele, S., Libert, C., Penalba, A., Montaner, J., Delgado, P. Tags: Imaging Source Type: research

Cardiac Hemodynamics are Linked With Structural and Functional Features of Brain Aging: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study Epidemiology
Conclusions A graded decrease in cardiac functioning is associated with features of brain aging. Older persons with cardiac or cognitive signs and symptoms may have both cardiac and cerebral diseases and should be evaluated accordingly.
Source: JAHA:Journal of the American Heart Association - January 27, 2015 Category: Cardiology Authors: Sabayan, B., van Buchem, M. A., Sigurdsson, S., Zhang, Q., Harris, T. B., Gudnason, V., Arai, A. E., Launer, L. J. Tags: Epidemiology Source Type: research