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Abstract P451: Cerebrovasuclular Events in Patients With Primary Aldosteronism: Results of the PA Sendai Study Registry Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Background: Hyperaldosteronism is associated with the risk of cardio-and cerebrovascular events (CVE) that is independent of blood pressure levels and Primary aldosteronism (PA) display a higher risk of CVE compared with essential hypertension (EH).Objective: Our objective was to elucidate the prevalence of symptomatic stroke in PA patients and to characterize their clinical features.Design and Setting: This was a retrospective cross-sectional single center study (PA Sendai Study registry) between 2007 and 2016 in Japan.Patient: 807 patients with PA were registered and analyzed. The all patients were performed adrenal veno...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masataka Kudo, Ryo Morimoto, Syuji Mugikura, Yuta Tezuka, Kei Omata, Mashiro Nezu, Yasuhiro Igarashi, Kazumasa Seiji, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh Tags: Poster Abstract Presentations Source Type: research

Abstract P452: Evaluation of Pathological Basis of a Shrsp-based Congenic Strain Characterized by Early Stroke Occurrence Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Objectives: The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-known model for essential hypertension and cerebral stroke. In the previous studies, we have identified a major blood pressure (BP) QTL on chromosome (chr) 1 of SHRSP and have explored gene(s) on the BP QTL responsible for hypertensive phenotypes of this strain through physiological analyses using reciprocal congenic strains between SHRSP and a normotensive control (Wistar-Kyoto rat, WKY). In a recent observation, we unexpectedly found that a SHRSP-based congenic strain, harboring a 0.3-Mbp fragment of the chr1 QTL, has developed stroke earlier t...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hiroki Ohara, Davis L Ngarashi, Toru Nabika Tags: Poster Abstract Presentations Source Type: research

The Value of N-Terminal Pro-B-Type Natriuretic Peptide in Determining Antihypertensive Benefit: Observations From the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Natriuretic Peptides
We investigated 3 hypotheses: (1) N-terminal pro–B-type natriuretic peptide (NT-proBNP) predicts cardiovascular disease events in patients with hypertension, (2) NT-proBNP is associated with blood pressure variability, and (3) NT-proBNP predicts benefit from antihypertensive regimens. The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) randomized a subset of 6549 patients at risk with no history of coronary heart disease to either atenolol-based or amlodipine-based blood pressure–lowering treatment. During 5.5 years of follow-up, 485 cardiovascular disease cases accrued and were matched with 1367 controls. Ba...
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Welsh, P., Poulter, N. R., Chang, C. L., Sever, P. S., Sattar, N., on behalf of the ASCOT Investigators Tags: Cerebrovascular disease/stroke Natriuretic Peptides Source Type: research

Central Pulse Pressure Is an Independent Determinant of Vascular Remodeling in the Retinal Circulation Retinal Vessels
Pulse pressure has been recognized as a risk factor for stroke. Moreover, it was shown that central pulse pressure relates more strongly to vascular disease and outcome than (peripheral) brachial pulse pressure. Because vascular remodeling in the retinal circulation mirrors the 1 in the cerebral circulation and represents an easy, noninvasive possibility to assess microvascular changes in humans, we analyzed the impact of central pulse pressure on retinal vascular structure in humans. The study cohort comprised 135 nondiabetic patients across a wide range of blood pressure values. Parameter of retinal arteriolar remodeling...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Ott, C., Raff, U., Harazny, J. M., Michelson, G., Schmieder, R. E. Tags: Remodeling Retinal Vessels Source Type: research

High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population White Matter Lesions
High blood pressure is considered an important risk factor for cerebral white matter lesions (WMLs) in the aging population. In a longitudinal population-based study of 665 nondemented persons, we investigated the longitudinal relationship of systolic blood pressure, diastolic blood pressure, and pulse pressure with annual progression of WMLs. Means of blood pressure were calculated over a 5-year period before longitudinal MRI scanning. WML progression was subsequently measured on 2 scans 3.5 years apart. We performed analyses with linear regression models and evaluated adjustments for age, sex, cardiovascular risk factors...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Verhaaren, B. F. J., Vernooij, M. W., de Boer, R., Hofman, A., Niessen, W. J., van der Lugt, A., Ikram, M. A. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Epidemiology White Matter Lesions Source Type: research