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Aldosterone Target NGAL (Neutrophil Gelatinase-Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NF{kappa}B PathwayNovelty and Significance Heart
In conclusion, NGAL, a downstream MR activation target, is a key mediator of post-MI cardiac damage. NGAL may be a potential therapeutic target in cardiovascular pathological situations in which MR is involved.
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Ernesto Martinez–Martinez, Mathieu Buonafine, Ines Boukhalfa, Jaime Ibarrola, Amaya Fernandez–Celis, Peter Kolkhof, Patrick Rossignol, Nicolas Girerd, Paul Mulder, Natalia Lopez–Andres, Antoine Ouvrard–Pascaud, Frederic Jaisser Tags: Basic Science Research Original Articles Source Type: research

Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular EventsNovelty and Significance Arterial Stiffness
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in rel...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang-Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R. Chugh, Alban Redheuil, Chia-Ying Liu, Colin O. Wu, W. Gregory Hundley, David A. Bluemke, Eliseo Guallar, Joao A.C. Lima Tags: Epidemiology, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study Epidemiology/Population
In conclusion, aortic stiffness was associated with cognitive function and markers of subclinical brain injury in young to middle-aged adults. Prospective studies are needed to examine whether aortic stiffening in young adulthood is associated with vascular cognitive impairment later in life.
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Pase, M. P., Himali, J. J., Mitchell, G. F., Beiser, A., Maillard, P., Tsao, C., Larson, M. G., DeCarli, C., Vasan, R. S., Seshadri, S. Tags: Aging, Risk Factors, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Cognitive Impairment Epidemiology/Population Source Type: research

Hypertensive Target Organ Damage and Longitudinal Changes in Brain Structure and Function: The Second Manifestations of Arterial Disease-Magnetic Resonance Study Cognitive Decline and Blood Pressure
We examined the association of hypertensive target organ damage with longitudinal changes in brain structure and function within the Second Manifestations of Arterial Disease–Magnetic Resonance (SMART-MR) study. Renal function, albuminuria, and left ventricular hypertrophy on electrocardiography were measured in 663 patients with manifest arterial disease (mean age, 57±9 years; 81% men). Automated brain segmentation was used to quantify progression of global brain atrophy (change in brain parenchymal fraction) and progression of cerebral small vessel disease on 1.5T magnetic resonance imaging, and memory and e...
Source: Hypertension - November 11, 2015 Category: Cardiology Authors: van der Veen, P. H., Geerlings, M. I., Visseren, F. L. J., Nathoe, H. M., Mali, W. P. T. M., van der Graaf, Y., Muller, M., for the SMART Study Group* Tags: Risk Factors, Hypertension, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Vascular Disease Cognitive Decline and Blood Pressure Source Type: research

Abstract P075: Stroke Volume and Visceral Fat Drive Differences in Blood Pressure Between Two Generations: A Population-Based Study of Adolescents and Their Parents Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Excess total body fat (TBF) and visceral fat (VF) are major risk factors of hypertension. Blood pressure (BP) increases with age, as do TBF and VF. Here we investigated whether TBF and VF contribute to BP differences between adolescents and adults. A population-based sample of adolescents (n=933, 12-18 years) and their parents (n=429, 38-65 years) was studied as part of the Saguenay Youth Study. In all participants, beat-by-beat values of SBP, DBP and underlying hemodynamic parameters (heart rate, stroke volume [SV] and total peripheral resistance) were obtained with a Finometer during a 52-minute protocol mimicking daily ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Syme, C. A., Abrahamowicz, M., Leonard, G., Perron, M., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension Cerebral Small Vessel Disease
Blood pressure (BP) variability is associated with stroke risk, but less is known about subclinical cerebral small vessel disease (CSVD). We aimed to determine whether CSVD relates to short-term BP variability independently of BP levels and also, whether they improve CSVD discrimination beyond clinical variables and office BP levels. This was a cohort study on asymptomatic hypertensives who underwent brain magnetic resonance imaging and 24-hour ambulatory BP monitoring. Office and average 24-hour, daytime and nighttime BP levels, and several metrics of BP variability (SD, weighted SD, coefficient of variation, and average ...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Filomena, J., Riba-Llena, I., Vinyoles, E., Tovar, J. L., Mundet, X., Castane, X., Vilar, A., Lopez-Rueda, A., Jimenez-Balado, J., Cartanya, A., Montaner, J., Delgado, P., on behalf of ISSYS Investigators Tags: Clinical Studies, Cerebral Lacunes Cerebral Small Vessel Disease Source Type: research

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds Brain and Cognition
Previous studies on the relationship between subjective cognitive failures (SCF) and objective cognitive function have shown inconsistent results. In addition, research on the association between SCF and imaging markers of cerebral small vessel disease is limited. We investigated whether SCF in patients with essential hypertension, who are at high risk of cerebral small vessel disease, are associated with objective cognitive function and magnetic resonance imaging manifestations of cerebral small vessel disease. We included 109 patients with hypertension who underwent extensive neuropsychological assessment, including ques...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Uiterwijk, R., Huijts, M., Staals, J., Duits, A., Gronenschild, E., Kroon, A. A., de Leeuw, P. W., van Oostenbrugge, R. J. Tags: Cerebrovascular disease/stroke Brain and Cognition Source Type: research

Prevalence and Associated Factors of Silent Brain Infarcts in a Mediterranean Cohort of Hypertensives Brain and Cognition
Silent brain infarcts (SBIs) are detected by neuroimaging in approximately 20% of elderly patients in population-based studies. Limited evidence is available for hypertensives at low cardiovascular risk countries. Investigating Silent Strokes in Hypertensives: a Magnetic Resonance Imaging Study (ISSYS) is aimed to assess the prevalence and risk factors of SBIs in a hypertensive Mediterranean population. This is a cohort study in randomly selected hypertensives, aged 50 to 70 years old, and free of clinical stroke and dementia. On baseline, all participants underwent a brain magnetic resonance imaging to assess prevalence a...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Delgado, P., Riba-Llena, I., Tovar, J. L., Jarca, C. I., Mundet, X., Lopez-Rueda, A., Orfila, F., Llussa, J., Manresa, J. M., Alvarez-Sabin, J., Nafria, C., Fernandez, J. L., Maisterra, O., Montaner, J., on behalf of ISSYS Investigators* Tags: Cerebral Lacunes Brain and Cognition Source Type: research

High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population White Matter Lesions
High blood pressure is considered an important risk factor for cerebral white matter lesions (WMLs) in the aging population. In a longitudinal population-based study of 665 nondemented persons, we investigated the longitudinal relationship of systolic blood pressure, diastolic blood pressure, and pulse pressure with annual progression of WMLs. Means of blood pressure were calculated over a 5-year period before longitudinal MRI scanning. WML progression was subsequently measured on 2 scans 3.5 years apart. We performed analyses with linear regression models and evaluated adjustments for age, sex, cardiovascular risk factors...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Verhaaren, B. F. J., Vernooij, M. W., de Boer, R., Hofman, A., Niessen, W. J., van der Lugt, A., Ikram, M. A. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Epidemiology White Matter Lesions Source Type: research

Left Ventricular Global Function Index by Magnetic Resonance Imaging--A Novel Marker for Assessment of Cardiac Performance for the Prediction of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology/Population Science
Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was def...
Source: Hypertension - March 13, 2013 Category: Cardiology Authors: Mewton, N., Opdahl, A., Choi, E.-Y., Almeida, A. L. C., Kawel, N., Wu, C. O., Burke, G. L., Liu, S., Liu, K., Bluemke, D. A., Lima, J. A. C. Tags: Congestive, Risk Factors, Hypertrophy, CT and MRI Epidemiology/Population Science Source Type: research