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Abstract 137: Sox6 Regulates Renin Expression During Juxtaglomerular Cell Expansion Session Title: Renin Angiotensin System II
Introduction: Hypertension, a common condition that affects 33% of the US population, is a major risk factor for heart disease and stroke. Treatments for hypertension are limited and there is a critical need to develop new therapies. The Renin Angiotensin Aldosterone System (RAAS) plays a key role in regulating blood pressure, and renin controls its rate-limiting step. In adults, renin is produced and stored by renal Juxtaglomerular (JG) cells. During sodium restriction and other pathophysiological stresses that require an increase in renin expression and release, the adult kidney increases the number of cells expressing r...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jason D Foss, Liang Xiao, Kandi D Horton, Mohammad Saleem, Conrad P Hodgkinson, David G Harrison, Jose A Gomez Tags: Oral Abstract Presentations Source Type: research

Abstract P445: Sympathetic and Renal Mechanisms of Age-related Hypertension Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Hypothesis: Sympathoexcitation and sodium retention contribute to age-related hypertension (HTN).Methods: Three, 8, and 16 month old male SD rats underwent an IV volume expansion (VE; 5% BW) and MAP, HR, urine output and paraventricular nucleus (PVN) neuronal activation (c-Fos expression) were assessed. In separate groups of rats fed a 21 day normal (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet, measures of 1) ex vivo afferent renal nerve (ARN) activity (norepinephrine (NE)-evoked substance P release) or 2) MAP, HR, NCC activity (ΔUNaV to IV HCTZ, 2mg/kg) and sympathetic tone (plasma and renal NE content, ΔMAP to IV he...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Richard D Wainford, Alissa A Frame Tags: Poster Abstract Presentations Source Type: research

Abstract 104: Cerebrovascular and Cognitive Dysfunction in DOCA-Salt Hypertension is Mediated by Perivascular Macrophages Session Title: Salt and Hypertension
Hypertension (HTN) and high-salt diets are important risk factors for stroke and dementia. DOCA-salt is a recognized model of HTN driven by sodium retention and brain renin-angiotensin system (RAS) activation. However, it is unknown whether essential mechanisms regulating the cerebral circulation are altered in DOCA-salt mice, and, if so, whether these alterations are associated with cognitive impairment. To this end, C57BL/6 mice were implanted with 50mg DOCA pellets SQ and received 0.9% NaCl drinking water for 3 weeks. Cerebral blood flow (CBF) was measured in the somatosensory cortex by laser-Doppler flowmetry through a...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Monica M Santisteban, Giuseppe Faraco, Gianfranco Racchumi, Josef Anrather, Costantino Iadecola Tags: Oral Abstract Presentations Source Type: research