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Source: Journal of Vascular Surgery
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Total 705 results found since Jan 2013.
Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis
A subgroup analysis was conducted of patients with carotid atherosclerosis in the NAVIGATE (New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial Versus ASA to Prevent Embolism)-ESUS (Embolic Stroke of Undetermined Source) trial, which was an international, double-blinded, randomized phase 2 trial between December 2014 and September 2017.
Source: Journal of Vascular Surgery - November 22, 2019 Category: Surgery Authors: G. Ntaios, B. Swaminathan, S.D. Berkowitz, R.J. Gagliardi, W. Lang, J.E. Siegler, NAVIGATE ESUS Investigators. Tags: Anticoagulation is not better than aspirin to prevent stroke in patients with carotid atherosclerosis Source Type: research
Reduction in Early Stroke Risk in Carotid Stenosis With Transient Ischemic Attack Associated With Statin Treatment
In patients with acute symptomatic carotid stenosis, statin pretreatment is associated with reduced stroke risk. Carotid endarterectomy (CEA) in patients with associated symptoms is highly effective for secondary stroke prevention. Maximum benefit appears to be in those who undergo surgery ≤2 weeks of symptom onset; however, the safety of very early CEA has been questioned. Data from the Swedish Vascular Registry indicated an 11.5% stroke and death rate in patients undergoing CEA ≤48 hours of symptom onset. This is a fourfold increase in the odds of a poor outcome compared with those undergoing CEA from 3 to 7 days (S...
Source: Journal of Vascular Surgery - January 24, 2014 Category: Surgery Authors: Á. Merwick, G.W. Albers, E.M. Arsava Tags: Abstracts Source Type: research
The effect of postoperative stroke and myocardial infarction on long-term survival after carotid revascularization
Introduction: The largest randomized controlled trial that compared the efficacy of carotid endarterectomy (CEA) with carotid artery stenting (CAS) showed equivalent outcomes for the composite end point of postoperative stroke, myocardial infarction (MI), or death. However, CAS had a higher risk of postoperative stroke, and CEA had a higher risk of MI. We hypothesize that there is a differential association of postoperative stroke, compared with that of postoperative MI, with reduced long-term survival after carotid revascularization when compared with neither complication.Methods: The Vascular Study Group of New England d...
Source: Journal of Vascular Surgery - February 11, 2013 Category: Surgery Authors: Jessica P. Simons, Philip P. Goodney, Donald T. Baril, Brian W. Nolan, Nathanael D. Hevelone, Jack L. Cronenwett, Louis M. Messina, Andres Schanzer, Vascular Study Group of New England Tags: Clinical research studies Source Type: research
Prevalence of Stenoses and Occlusions of Brain-Supplying Arteries in Young Stroke Patients
One-fifth of young patients with stroke have asymptomatic or symptomatic large-artery atherosclerosis. Significant extracranial atherosclerotic carotid stenosis and occlusions in adult stroke patients of all ages (21-94 years old) occur in 11% to 22% (Bogousslavsky J et al, Stroke 1988;19:1083-92 and Wasay M et al, Stroke 2009;40:708-12). However, in younger patients with stroke, atherosclerotic changes in the extracranial and large intracranial arteries have not been considered a major etiology of stroke. Only two previous studies have reported the prevalence of atherosclerotic stenosis in young stroke patients, with pre...
Source: Journal of Vascular Surgery - August 28, 2013 Category: Surgery Authors: B. von Sarnowski, U. Schminke, T. Tatlisumak Tags: Abstracts Source Type: research
The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes
Conclusions: These results suggest that eNOS activation is required for the neuroprotection of insulin against ischemic stroke in patients with diabetes.Clinical Relevance: Our findings indicate that the impact of insulin in patients with diabetes with acute ischemic stroke is concurrently dependent on both endothelial nitric oxide synthase (eNOS) signaling and antihyperglycemic effects. When eNOS dysfunction (eg, vascular endothelial dysfunction) is developed in patients with diabetes, the beneficial effect of insulin might be diminished in acute ischemic stroke in spite of its preserved antihyperglycemic effect. For diab...
Source: Journal of Vascular Surgery - May 9, 2013 Category: Surgery Authors: Shiang-Suo Huang, Yi-Jhu Lu, Jiung-Pang Huang, Yang-Tzu Wu, Yuan-Ji Day, Li-Man Hung Tags: Basic research studies Source Type: research
Carotid Plaque MRI and Stroke Risk: A Systematic Review and Meta-analysis
Dedicated magnetic resonance imaging (MRI) of plaque composition offers stroke risk information beyond measurement of luminal stenosis in carotid atherosclerotic disease. Stenosis severity is widely used as a marker for stroke risk in patients with atherosclerotic carotid disease. However, evidence also suggests plaque composition can also predict stroke risk independent of stenosis severity (den Hartog AG et al, Eur J Vasc Endovasc Surg 2013;45:7-21). MRI measurements of plaque composition may help characterize carotid plaques with respect to stroke risk. However, individual studies have been relatively small, and it is ...
Source: Journal of Vascular Surgery - March 24, 2014 Category: Surgery Authors: A. Gupta, H. Baradaran, A.D. Schweitzer Tags: Abstracts Source Type: research
Predictors and clinical significance of progression or regression of asymptomatic carotid stenosis
Conclusions: Progressive asymptomatic carotid stenosis identified a subgroup with about twice the risk of ipsilateral stroke compared with those without progression. However, the clinical value of screening for progression simply for selecting patients for carotid procedures is limited because of the low frequency of progression and its relatively low associated stroke rate. The cost effectiveness of screening for change in stenosis severity to better direct current optimal medical treatment needs testing.
Source: Journal of Vascular Surgery - December 30, 2013 Category: Surgery Authors: Stavros K. Kakkos, Andrew N. Nicolaides, Ioanna Charalambous, Dafydd Thomas, Argyrios Giannopoulos, A. Ross Naylor, George Geroulakos, Anne L. Abbott, Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS) Study Group Tags: Clinical research studies Source Type: research
Risk index for predicting perioperative stroke, myocardial infarction, or death risk in asymptomatic patients undergoing carotid endarterectomy
Objective: The latest guidelines recommend performance of carotid endarterectomy (CEA) on asymptomatic patients with high-grade carotid stenosis, only if the combined perioperative stroke, myocardial infarction (MI), or death risk is ≤3%. Our objective was to develop and validate a risk index to estimate the combined risk of perioperative stroke, MI, or death in asymptomatic patients undergoing elective CEA.Methods: Asymptomatic patients who underwent an elective CEA (n = 17,692) were identified from the 2005-2010 National Surgical Quality Improvement Program, a multicenter, prospective database. Multivariable logistic ...
Source: Journal of Vascular Surgery - November 19, 2012 Category: Surgery Authors: Prateek K. Gupta, Bala Ramanan, Jason N. MacTaggart, Abhishek Sundaram, Xiang Fang, Himani Gupta, Jason M. Johanning, Iraklis I. Pipinos Tags: Clinical research studies Source Type: research
Characterization of Perioperative Contralateral Stroke After Carotid Endarterectomy
Contralateral stroke is an infrequent cause of perioperative stroke after carotid endarterectomy (CEA). Whereas the risks of ipsilateral stroke complicating CEA have been discriminated, factors that lead to contralateral stroke are poorly defined. The goal of this study was to identify the risk of perioperative (30-day) contralateral stroke after CEA as well as predisposing preoperative and operative factors.
Source: Journal of Vascular Surgery - September 22, 2016 Category: Surgery Authors: W. Darrin Clouse, Emel Ergul, Virendra I. Patel, R. Todd Lancaster, Glenn M. LaMuraglia, Richard P. Cambria, Mark F. Conrad Tags: Abstract from the 2016 New England Society for Vascular Surgery Annual Meeting Source Type: research
Characterization of perioperative contralateral stroke after carotid endarterectomy
Contralateral stroke is an infrequent cause of perioperative stroke after carotid endarterectomy (CEA). Whereas the risks of ipsilateral stroke complicating CEA have been discriminated, factors that lead to contralateral stroke are poorly defined. The purpose of this study was to identify the risk of perioperative (30-day) contralateral stroke after CEA as well as predisposing preoperative and operative factors. Its specific effect on long-term survival was interrogated.
Source: Journal of Vascular Surgery - July 8, 2017 Category: Surgery Authors: W. Darrin Clouse, Emel A. Ergul, Virendra I. Patel, R. Todd Lancaster, Glenn M. LaMuraglia, Richard P. Cambria, Mark F. Conrad Tags: Clinical paper Source Type: research
CAD 5. Risk Factors for Stroke After Carotid Surgical Interventions
We aimed to assess stroke rates after carotid revascularization surgery and to identify factors influencing stroke. The primary end point was the incidence of 30-day periprocedural major stroke and the time to stroke postoperatively. Secondary end points included minor stroke, myocardial infarction, and overall survival.
Source: Journal of Vascular Surgery - October 22, 2018 Category: Surgery Authors: Wael Tawfick, Makinderjit Dulai, Niamh Hynes, Sherif Sultan Source Type: research
Stroke rate after endovascular aortic interventions in the Society for Vascular Surgery Vascular Quality Initiative
The stroke rate after endovascular aneurysm repair (EVAR), particularly complex EVAR such as fenestrated EVAR (FEVAR) and chimney EVAR (chEVAR), is not well defined. Whereas stroke is a well-established risk of thoracic endovascular aortic repair (TEVAR), the impact of procedural characteristics on stroke remains unclear. Therefore, we characterized the risk of stroke after endovascular aortic interventions in the Vascular Quality Initiative database and identified procedural characteristics associated with stroke.
Source: Journal of Vascular Surgery - April 1, 2020 Category: Surgery Authors: Nicholas J. Swerdlow, Patric Liang, Chun Li, Kirsten Dansey, Thomas F.X. O'Donnell, Livia E.V.M. de Guerre, Rens R.B. Varkevisser, Virendra I. Patel, Grace J. Wang, Marc L. Schermerhorn, the Society for Vascular Surgery Vascular Quality Initiative Source Type: research
Neurologic Outcomes of Carotid and Other Emergent Interventions for Ischemic Stroke Over 6 Years With Analysis Enhanced by Machine Learning
Despite continued evolution in treatment, stroke continues to represent one of the most common and debilitating diseases patients suffer. We created a novel machine-learning natural language processing algorithm to assist in performing outcomes research for patients undergoing treatment for stroke. This method enhanced our ability to accurately determine neurologic outcomes for all urgent stroke interventions. Results demonstrate stroke severity and functional neurologic outcomes for all ischemic stroke patients undergoing (1) urgent carotid endarterectomy (uCEA)/urgent carotid artery stenting (uCAS), (2) tissue plasminoge...
Source: Journal of Vascular Surgery - December 20, 2021 Category: Surgery Authors: P. Andrew Rivera, Bethany Jennings, Jeff Burton, Aaron Hayson, Faith Mason, Jaron Pettis, Adam Berenson, W.C. Sternbergh, Samuel Money, Daniel Fort, Hernan Bazan Source Type: research
Safety of carotid endarterectomy following thrombolysis for acute ischemic stroke
Conclusions: Despite slightly higher rates of postoperative hemorrhagic strokes than those in randomized trials, CEA appears safe following thrombolysis for acute ischemic stroke. However, more data on the timing of surgery is needed.
Source: Journal of Vascular Surgery - July 29, 2013 Category: Surgery Authors: Yao Pey Yong, John Saunders, Said Abisi, Nikola Sprigg, Krishna Varadhan, Shane MacSweeney, Nishath Altaf Tags: Review articles Source Type: research
