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Association of admission plasma glucose level and cerebral computed tomographic perfusion deficit volumes
Hyperglycemia in acute ischemic stroke (AIS) is frequent and associated with worse outcome. Yet, strict glycemic control in AIS patients has failed to yield beneficial outcome. So far, the underlying pathophysiological mechanisms of admission hyperglycemia in AIS have remained not fully understood. We aimed to evaluate the yet equivocal association of hyperglycemia with computed tomographic perfusion (CTP) deficit volumes.
Source: Journal of the Neurological Sciences - June 26, 2023 Category: Neurology Authors: Laura Mannism äki, Nicolas Martinez-Majander, Gerli Sibolt, Olli Suomalainen, Katariina Bäcklund, Ahmed Elseoud Abou, Juha Järveläinen, Nina Forss, Sami Curtze Source Type: research

Visual suppression of vestibulo-ocular reflex in patients treated with carotid artery revascularization: A potential biomarker for cerebral perfusion
Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for ischemic stroke prevention in patients with carotid artery stenosis. However, the beneficial effects of CEA/CAS for cerebral hypoperfusion due to carotid artery stenosis have yet to be fully established. As dizziness is a common symptom in patients with carotid artery stenosis, we aimed to evaluate the effects of CEA/CAS on cerebral function in patients with carotid artery stenosis, using equilibrium function tests.
Source: Journal of the Neurological Sciences - December 25, 2022 Category: Neurology Authors: Shigeta Miyake, Koji Takahashi, Yasunobu Nakai, Yu Amano, Ryoo Yamamoto, Kazumitsu Amari, Hiroya Hara, Ken Johkura Source Type: research

Association of hyperglycemia and computed tomographic perfusion deficits in patients who underwent endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion: A subgroup analysis of a randomized phase 3 trial (MR CLEAN)
Hyperglycemia is highly prevalent in patients with acute ischemic stroke and is associated with increased risk of symptomatic intracranial hemorrhage, larger infarct size and unfavorable outcome. Furthermore, glucose may modify the effect of endovascular treatment (EVT) in patients with ischemic stroke. Hyperglycemia might lead to accelerated conversion of penumbra into infarct core. However, it remains uncertain whether hyperglycemia on admission is associated with the size of penumbra or infarct core in acute ischemic stroke.
Source: Journal of the Neurological Sciences - June 30, 2022 Category: Neurology Authors: C.J.B.A. Kersten, A.A.M. Zandbergen, O.A. Berkhemer, J. Borst, M. Haalboom, Y.B.W.E.M. Roos, D.W.J. Dippel, R.J. van Oostenbrugge, A. van der Lugt, W.H. van Zwam, C.B. Majoie, H.M. den Hertog, on behalf of the MR CLEAN investigators Source Type: research

Comparison of automated infarct core volume measures between non-contrast computed tomography and perfusion imaging in acute stroke code patients evaluated for potential endovascular treatment
Patients with small core infarction and salvageable penumbra are likely to benefit from endovascular treatment (EVT). As computed tomography perfusion imaging (CTP) is not always available 24/7 for patient selection, many patients are transferred to stroke centers for CTP. We compared automatically measured infarct core volume (NCCTcore) from the non-contrast computed tomography (NCCT) with ischemic core volume (CTPcore) from CTP and the outcome of EVT to clarify if NCCTcore measurement alone is sufficient to identify patients that benefit from transfer to stroke centers for EVT.
Source: Journal of the Neurological Sciences - May 8, 2021 Category: Neurology Authors: Olli P. Suomalainen, Ahmed Abou Elseoud, Nicolas Martinez-Majander, Marjaana Tiainen, Nina Forss, Sami Curtze Source Type: research

Novel quantitative approach for crossed cerebellar diaschisis detection in acute ischemic stroke using CT perfusion
Crossed cerebellar diaschisis (CCD) is a common finding in hyper-acute ischemic stroke, related to supratentorial dysfunction of the contralateral hemisphere. Several studies investigated a possible relationship between CCD and clinical outcomes but still no evidence emerged. We used a novel quantitative whole cerebellum analysis using CT perfusion (CTP) imaging to investigate the relationship between CCD and stroke severity, hypoperfused volume and outcome measures.
Source: Journal of the Neurological Sciences - June 28, 2020 Category: Neurology Authors: Marcello Naccarato, Milo š Ajčević, Giovanni Furlanis, Carlo Lugnan, Alex Buoite Stella, Ilario Scali, Paola Caruso, Lara Stragapede, Maja Ukmar, Paolo Manganotti Source Type: research

Left thalamus infarction in the thalamotuberal artery perfusion area causing subcortical diaschisis and transcortical sensory aphasia
The thalamus is related to language function, and some thalamic stroke cases can cause aphasia [1]. However, most previous cases reporting thalamic damage-induced ipsilateral subcortical diaschisis and aphasia were hemorrhagic stroke [1,2]. Only a few left thalamus infarction cases showed cortical hypoperfusion concerned with the aphasia, but no single-photon emission computed tomography (SPECT) or thalamic nucleus data were available [3]. Thus, aphasia pathology due to cortical hypoperfusion following thalamus infarction, especially with respect to thalamic nuclei, is still unknown.
Source: Journal of the Neurological Sciences - January 24, 2020 Category: Neurology Authors: Kosuke Matsuzono, Kohei Furuya, Azusa Karube, Akie Horikiri, Tadashi Ozawa, Takafumi Mashiko, Haruo Shimazaki, Reiji Koide, Ryota Tanaka, Shigeru Fujimoto Tags: Letter to the Editor Source Type: research

Permeability surface area product analysis in malignant brain edema prediction – A pilot study
Using an extended CT perfusion acquisition (150s), we sought to determine the association between perfusion parameters and malignant edema after ischemic stroke.
Source: Journal of the Neurological Sciences - March 23, 2017 Category: Neurology Authors: O. Volny, P. Cimflova, T.-Y. Lee, B.K. Menon, C.D. d'Esterre Source Type: research

Mechanical embolectomy for acute ischemic stroke beyond six hours from symptom onset using MRI based perfusion imaging
There is very limited data on the use of MRI based perfusion imaging to select patients with acute ischemic stroke and large vessel occlusion (LVO) for intraarterial therapy beyond 6h from onset. Our aim is to report the outcome of patients with acute ischemic stroke and large artery occlusion who presented beyond 6h from onset, had favorable MRI imaging profile, and underwent mechanical embolectomy.
Source: Journal of the Neurological Sciences - February 20, 2017 Category: Neurology Authors: Ryan A. McTaggart, Shadi Yaghi, Daniel C Sacchetti, Richard A. Haas, Morgan Hemendinger, Daniel Arcuri, Jeffrey M. Rogg, Karen L. Furie, Mahesh V. Jayaraman Source Type: research

Diagnostic accuracy of computed tomography perfusion in patients with acute stroke: A meta-analysis
The purpose of this meta-analysis was to evaluate the sensitivity and specificity of computed tomography perfusion (CTP) in diagnosing acute ischemic stroke in patients presenting to the emergency department with stroke-like symptoms.
Source: Journal of the Neurological Sciences - November 25, 2015 Category: Neurology Authors: Ye Xin, Fu-Gang Han Source Type: research

Arterial spin-labeling magnetic resonance imaging for diagnosis of early seizure after stroke
Arterial spin-labeling (ASL) is a non-contrast-enhanced sequence of magnetic resonance imaging (MRI) to evaluate cerebral perfusion. ASL has been widely used in cerebrovascular diseases [1]. Previously, we reported the use of ASL for the diagnosis of late seizure after stroke [2]. Here we report a first case of ASL in a patient with early seizure after stroke.
Source: Journal of the Neurological Sciences - May 7, 2015 Category: Neurology Authors: Yosuke Miyaji, Yuichi Kawabata, Hideto Joki, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Motohiro Nomura, Yoshihisa Kitamura, Fumiaki Tanaka Tags: Letter to the Editor Source Type: research

CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA
Conclusion: CTP parameters derived from commercially available software and published thresholds yield little predictive value for good clinical outcomes for AIS patients treated with IV t-PA but may be useful in predicting poor clinical outcome especially if the area of non-viable tissue is greater than 30cm2.Highlights:
Source: Journal of the Neurological Sciences - April 1, 2014 Category: Neurology Authors: Tzu-Ching Wu, Clark Sitton, Andrew Potter, Ritvij Bowry, Preeti Sahota, Chunyan Cai, Peng Hui, Zhongxue Chen, Nicole Gonzales, Andrew Barreto, George Lopez, James C. Grotta, Sean I. Savitz Tags: Original Articles Source Type: research

Arterial spin-labeling magnetic resonance imaging for diagnosis of late seizure after stroke
Conclusions: ASL was able to reveal hyperperfusion and was of great diagnostic value in the peri-ictal phase of late seizure after stroke.
Source: Journal of the Neurological Sciences - February 10, 2014 Category: Neurology Authors: Yosuke Miyaji, Mutsumi Yokoyama, Yuichi Kawabata, Hideto Joki, Yuji Kushi, Yasutaka Yokoi, Jo Sasame, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Hiroshi Shima, Motohiro Nomura, Yoshihisa Kitamura, Fumiaki Tanaka Tags: Original Articles Source Type: research

Determinants of mismatch in acute ischaemic stroke
Abstract: Background: Multimodal CT or MR imaging may be helpful in guiding reperfusion therapy for stroke. However, access to multimodal imaging may frequently be limited. We hypothesised that certain clinical and non-enhanced CT (NECT) findings at initial assessment can potentially predict mismatch on CT perfusion (CTP) in patients with acute ischaemic stroke.Methods: We undertook an analysis of prospectively collected clinical and imaging data of consecutive patients with anterior circulation ischaemic stroke who underwent CTP during their initial assessment. NECT was read for early ischaemic change as measured by the A...
Source: Journal of the Neurological Sciences - August 26, 2013 Category: Neurology Authors: Laszlo K. Sztriha, Una Cusack, Naga Kandasamy, Jozef Jarosz, Lalit Kalra Tags: Original Articles Source Type: research

Embolism and impaired washout: A possible explanation of border zone strokes in hypereosinophilic syndrome
We describe 4 patients with stroke caused by hypereosinophilic syndrome, all of whom presented with border zone infarcts, and discuss the possible underlying mechanism. Cardioembolism (endomiocardial fibrosis) would coexist with impaired washout (perfusion disturbance due to high eosinophil count and/or eosinophil-derived substances), explaining the watershed characteristics of the infarcts.
Source: Journal of the Neurological Sciences - January 7, 2013 Category: Neurology Authors: Lago Aida, Vera Parkhutik, Jose Ignacio Tembl, Nuria Martín, Marina Frasquet, Luis Bataller Tags: Short Communications Source Type: research