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Apolipoprotein E genotypes in stroke patients from urban Tanzania
Stroke disproportionately affects low- and middle-income countries (LMICs) with an increasing burden in Sub-Saharan African populations, who are undergoing an epidemiological transition. The ε2 and ε4 gene variants of apolipoprotein E (ApoE) are each linked to an increased risk of intracerebral hemorrhage [1], although the mechanisms of this association are not well understood. There also appear to be connections between ischemic stroke and ApoE gene variants, especially ε4, although these are less established [2].
Source: Journal of the Neurological Sciences - June 25, 2022 Category: Neurology Authors: Dylan R. Rice, Andre C. Vogel, Seif S. Ismail, Kigocha Okeng'o, Grace K. Lugemwa, Jonathan Henry, Christina Kourkoulis, Farrah J. Mateen Source Type: research

MAMBO: Measuring ambulation, motor, and behavioral outcomes with post-stroke fluoxetine in Tanzania: Protocol of a phase II clinical trial
Sub-Saharan Africa has a high stroke incidence and post-stroke morbidity. An inexpensive pharmacological treatment for stroke recovery would be beneficial to patients in the region. Fluoxetine, currently on the World Health Organization Essential Medicines List, holds promise as a treatment for motor recovery after ischemic stroke, but its effectiveness is controversial and untested in this context in Sub-Saharan Africa.
Source: Journal of the Neurological Sciences - November 5, 2019 Category: Neurology Authors: AndreC. Vogel, Kigocha Okeng'o, Faraja Chiwanga, Seif Sharif Ismail, Deus Buma, Lindsay Pothier, Farrah J. Mateen Source Type: research