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Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank
This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS.
Source: Journal of the Neurological Sciences - September 13, 2023 Category: Neurology Authors: Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Ma Source Type: research

The safety and efficacy of periprocedural intravenous anticoagulants for acute ischemic stroke patients who underwent endovascular treatment: Sub-analysis of the RESCUE-Japan Registry 2
The efficacy and safety of periprocedural anticoagulant therapy are still controversial. We investigated the effects of periprocedural anticoagulation on patients who underwent endovascular therapy (EVT) for acute ischemic stroke (AIS). The patients were dichotomized into two groups according to the use of intravenous anticoagulant during or within 24  h after EVT (AC or non-AC group). Primary outcome was defined as a modified Rankin Scale (mRS) score of 0–2 at 90 days. Safety outcomes were defined as any or symptomatic intracerebral hemorrhages (ICH).
Source: Journal of the Neurological Sciences - August 23, 2022 Category: Neurology Authors: Hirofumi Matsubara, Yukiko Enomoto, Egashira Yusuke, Kazutaka Uchida, Hiroshi Yamagami, Nobuyuki Sakai, Shinichi Yoshimura Source Type: research

Impact of prior antiplatelet therapy on outcomes of endovascular therapy for acute ischemic stroke with large vessel occlusion: Sub-analysis of the RESCUE-Japan Registry 2
The impact of prior antiplatelet therapy (APT) on clinical outcomes of endovascular therapy (EVT) for large vessel occlusion (LVO) on clinical outcomes is uncertain. We explored the associations between prior APT and in-hospital and 90-day outcomes in a real-world setting.
Source: Journal of the Neurological Sciences - May 10, 2022 Category: Neurology Authors: Satoru Fujiwara, Nobuyuki Sakai, Hirotoshi Imamura, Nobuyuki Ohara, Kanta Tanaka, Hiroshi Yamagami, Yasushi Matsumoto, Masataka Takeuchi, Kazutaka Uchida, Shinichi Yoshimura, Takeshi Morimoto, RESCUE-Japan Registry 2 Investigators Source Type: research

Influence of single pass recanalization in acute ischemic stroke with large vessel occlusion in patients of Asian ethnicity
A previous report revealed single pass recanalization was associated with better functional outcome for patients with acute ischemic stroke with large vessel occlusion in real-world settings. However, the effect of single pass recanalization in acute large vessel occlusion based on the largest registry in real-world settings in Asian population are not well scrutinized.
Source: Journal of the Neurological Sciences - December 9, 2021 Category: Neurology Authors: Soichiro Numa, Kazutaka Uchida, Nobuyuki Sakai, Hiroshi Yamagami, Manabu Shirakawa, Hiroto Kageyama, Takeshi Morimoto, Shinichi Yoshimura, Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Registry 2 (RESCUE-Japan Registry 2) Invest Source Type: research

Risk factors, etiology, and outcome of ischemic stroke in young adults: A Japanese multicenter prospective study
This study aimed to evaluate the risk factors, etiology, and outcomes of ischemic stroke (IS) in Japanese young adults.
Source: Journal of the Neurological Sciences - July 28, 2020 Category: Neurology Authors: Yu Kono, Yuka Terasawa, Kenichiro Sakai, Yasuyuki Iguchi, Yasuhiro Nishiyama, Chikako Nito, Satoshi Suda, Kazumi Kimura, Takao Kanzawa, Ichiro Imafuku, Takahiro Nakayama, Masayuki Ueda, Takeshi Iwanaga, Tomoyuki Kono, Kazuo Yamashiro, Ryota Tanaka, Seiji Source Type: research

Elevated cardio-ankle vascular index may be related to future stroke risk in Japanese subjects
The cardio-ankle vascular index (CAVI) has been proposed as a useful parameter for arteriosclerotic diseases. However, whether it is associated with stroke risk in Japanese subjects remains unclear.
Source: Journal of the Neurological Sciences - April 27, 2020 Category: Neurology Authors: Yasuhiro Nishiyama, Toshiaki Otsuka, Kanako Muraga, Katsuhito Kato, Yoshiyuki Saiki, Hiroshi Nagayama, Kazumi Kimura Source Type: research

Pathogenicity of the variant m.13376  T  >  C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14  years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Pathogenicity of the variant m.13376  T  >  C in ND5 remains unproven
With interest we read the article by Sasaki et al. about a 14  years old Japanese female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome being attributed to the variant m.13376 T > C in ND5 [1]. The variant had been transmitted via the maternal line as the mother carried the same variant with high heteroplasmy rate but manifested differentially with only short stature and headache [1] The study has a number of shortcomings.
Source: Journal of the Neurological Sciences - December 4, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

A novel homoplasmic mitochondrial DNA mutation (m.13376T > C, p.I347T) of MELAS presenting characteristic medial temporal lobe atrophy
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited mitochondrial cytopathy that usually affects people under 40  years of age with variable symptoms [1]. The prevalence of MELAS syndrome in Japan was reported to be 0.2: 100,000 [2]. MELAS can be diagnosed by serum analyses under an aerobic exercise test, brain magnetic resonance imaging (MRI), muscle biopsy and mitochondrial DNA (mtDNA) analysis [3]. Approx imately 80% of MELAS cases are caused by a mutation m.3243A > G of the mitochondrial transfer RNA gene [4].
Source: Journal of the Neurological Sciences - October 24, 2019 Category: Neurology Authors: Ryo Sasaki, Yasuyuki Ohta, Noriko Hatanaka, Koh Tadokoro, Emi Nomura, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yoshio Omote, Eisaku Morimoto, Sanae Teshigawara, Jun Wada, Yu-ichi Goto, Koji Abe Tags: Letter to the Editor Source Type: research

Effect of icosapent ethyl on stroke risk: Different strokes for different folks?
In the Reduction of Cardiovascular Events with Icosapent Ethyl –Intervention Trial (REDUCE-IT) [1], among patients with elevated triglycerides on statins, ischemic event risk was lower among those who received icosapent ethyl vs. placebo. However, while coronary events were reduced in both REDUCE-IT and another pure EPA trial, Japan EPA lipid intervention stu dy (JELIS) [2], ischemic stroke risk was lowered in REDUCE-IT (HR 0.64, 0.49-0.85), but not decreased in JELIS (HR 0.97, 0.85-1.10). The discrepancy between these two pure EPA trials might be due to the varied race-ethnicity composition of participants, since partic...
Source: Journal of the Neurological Sciences - April 18, 2019 Category: Neurology Authors: Meng Lee, Bruce Ovbiagele Tags: Letter to the Editor Source Type: research