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Pediatric arterial ischemic stroke in Japan: Moyamoya disease or not
In this study, among 93 responders from physicians in 50 pediatric hospitals, consensus agreement, being available to treat pediatric AIS, was 90.3% in the use of intravenous tissue plasminogen activator (tPA) and 77.4% in mechanical thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2023 Category: Neurology Authors: Shunji Mugikura, Naoko Mori Tags: Letter to the Editor Source Type: research

Comparison of primary and secondary stroke prevention in patients with nonvalvular atrial fibrillation: Results from the RAFFINE registry
Atrial fibrillation (AF) is a predictor of severe stroke and early death in acute ischemic stroke patients.1 The prevalence of AF has increased as the Japanese population has aged.2 AF has been more common among patients with ischemic stroke than previously reported.3 In particular, AF patients with a history of stroke or TIA have had higher risks for stroke, hemorrhagic events, and death compared to those without.4,5 In these previous studies, most patients received warfarin for anticoagulation therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - November 7, 2022 Category: Neurology Authors: Kazuo Yamashiro, Ryota Tanaka, Sakiko Miyazaki, Katsumi Miyauchi, Hidemori Hayashi, Yuji Nishizaki, Shuko Nojiri, Satoru Suwa, Masataka Sumiyosi, Yuji Nakazato, Takao Urabe, Nobutaka Hattori, Tohru Minamino, Hiroyuki Daida Source Type: research

Modified Rankin scale assessment by telephone using a simple questionnaire
: The modified Rankin Scale (mRS) is widely used as a measure of post-stroke physical disability in clinical stroke trials; however, it is affected by inter-rater discrepancies. A Japanese version of the simplified mRS questionnaire (J-RASQ) has the potential to overcome the inter-rater discrepancies and might be feasible for clinical surveys. We aimed to determine the reliability of J-RASQ in a telephone survey administered by non-medical staff.
Source: Journal of Stroke and Cerebrovascular Diseases - August 30, 2022 Category: Neurology Authors: Kenichiro Yi, Makoto Nakajima, Tomoaki Ikeda, Mineko Yoshigai, Mitsuharu Ueda Source Type: research

Trends in surgical procedures for spontaneous intracerebral hemorrhage in Japan
Minimally invasive surgery for spontaneous intracerebral hemorrhage (ICH) has become increasingly popular in recent years. However, there are no reports on the recent trends in surgical procedures for spontaneous ICH. To investigate current trends in surgical methods for spontaneous ICH using a nationwide inpatient database from Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2022 Category: Neurology Authors: Shigeyuki Tahara, Yujiro Hattori, Shotaro Aso, Kazuaki Uda, Ryosuke Kumazawa, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Akio Morita Source Type: research

Potential crowdedness of mechanical thrombectomy and cerebral infarction mortality in Japan: Application of inverted two-step floating catchment area method
This study aimed to evaluate a stroke medical delivery system based on population coverage and the potential crowdedness index (PCI) of mechanical thrombectomy and investigate the relationship between PCI and cerebral infarction mortality in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - July 5, 2022 Category: Neurology Authors: Kazuki Ohashi, Kensuke Fujiwara, Toshiya Osanai, Takumi Tanikawa, Kyohei Bando, Shojiro Yamasaki, Tomohiro Aoki, Songzi Gu, Katsuhiko Ogasawara Source Type: research

Moyamoya Disease Associated with a Deficiency of Complement Component 6
Complement component 6 (C6) deficiency is a very rare genetic defect that leads to significantly diminished synthesis, secretion, or function of C6. In the current report, we demonstrate a previously undescribed, homozygous missense mutation in exon 17 of the C6 gene (c.2545A>G p.Arg849Gly) in a 35-year-old Japanese woman with moyamoya disease and extremely low levels of CH50 (
Source: Journal of Stroke and Cerebrovascular Diseases - June 16, 2022 Category: Neurology Authors: Masaru Kato, Yuki Kudo, Masanao Hatase, Naohisa Tsuchida, Shuhei Takeyama, Taku Sugiyama, Miki Fujimura, Ichiro Yabe, Hiroshi Tsujimoto, Yasuo Fukumori, Norimitsu Inoue, Tatsuya Atsumi Source Type: research

Care-needs Certification in the National Long-Term Care Insurance is Useful for Assessment of Premorbid Function in Older Japanese Patients with Stroke
To investigate the effects of premorbid long-term care insurance (LTCI) care-need certification on functional improvement during acute hospitalization in older patients with stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2022 Category: Neurology Authors: Arisa Kamo, Masafumi Nozoe, Hiroki Kubo, Shinichi Shimada Source Type: research

Relationship between Alcohol Intake and Stroke Severity in Japanese Patients: a Sex- and Subtype-Stratified Analysis
Stroke is a severe disease that causes disability in many patients, warranting the urgent development of treatment options.1-4 Previous studies have reported that the risk of hemorrhagic stroke (HS) linearly increases with increasing alcohol intake.5-12 Furthermore, moderate alcohol intake has been shown to lower the risk of ischemic stroke (IS), and a J-curve association has been observed between alcohol consumption and morbidity rate of IS.7-14 These reports were similar in that they considered alcohol intake as a risk factor for stroke development.
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2022 Category: Neurology Authors: Hiroyuki Shiotsuki, Yasuaki Saijo, Yoichi Ogushi, Shotai Kobayashi Source Type: research

Association Between Oral Anticoagulants and Stroke Severity at Onset in Elderly Patients with Cardioembolic Stroke Due to Non-Valvular Atrial Fibrillation
The prevention of cardioembolic stroke is an important public health priority in Japan due to its high prevalence in elderly individuals. Compared to their younger counterparts, elderly patients with cardioembolic stroke are more likely to have multiple comorbidities, a higher risk of serious complications, such as pneumonia and heart failure, and cognitive impairments (e.g., dementia or delirium), which may adversely affect their ability to participate in active rehabilitation. These factors negatively affect clinical outcomes, and many elderly stroke survivors require long-term care despite the early implementation of intensive therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - December 25, 2021 Category: Neurology Authors: Ichiro Deguchi, Takashi Osada, Shinichi Takahashi Source Type: research

Stroke Risk Due to Smoking Characterized by Sex Differences in Japan: The Jichi Medical School Cohort Study
Globally, smoking is a serious health problem, with detrimental effects caused by exposure to smoke. Although smoking is an avoidable risk factor, it accounts for approximately 8 million deaths annually,1 and can reduce life expectancy by 10 years.2 In Japan, the average smoking prevalence has been declining year by year, with a male smoking prevalence of 27.1% and a female smoking prevalence of 7.6% in 2019.3 However, smoking prevalence remains high in middle age, and smoking cessation is a goal that has not yet been achieved.
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2021 Category: Neurology Authors: Fumitaka Sato, Yosikazu Nakamura, Kazunori Kayaba, Shizukiyo Ishikawa Source Type: research

Impact of Low Ambient Temperature on the Occurrence of Spontaneous Intracerebral Hemorrhage-Analysis of Population-Based Stroke Registry in Toyama, Japan
Although several studies have reported that some meteorological factors such as ambient temperature and atmospheric pressure, affect the incidence of spontaneous intracerebral hemorrhage (ICH), the correlation remains unclear. This retrospective time-series analysis was aimed to clarify the effects of meteorological parameters on the incidence of ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2021 Category: Neurology Authors: Shusuke Yamamoto, Masaki Koh, Kenta Matsumura, Kei Hamazaki, Hidekuni Inadera, Satoshi Kuroda Source Type: research

Impact of coronavirus disease 2019 on time delay and functional outcome of mechanical thrombectomy in Tokyo, Japan
Several papers from around the world have reported that outbreaks of coronavirus disease 2019 (COVID-19) have led to the following time delays associated with endovascular mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS): onset-to-door (O2D) time,1,2 door-to-puncture (D2P) time and door-to-recanalization time.3 Several speculative factors may explain these delays, such as a collapse of emergency services focused on patients with COVID-192 and patients ’ fear of exposure to COVID-19 through interactions within the health-care system.
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2021 Category: Neurology Authors: Masahiro Katsumata, Takahiro Ota, Junya Kaneko, Hiroyuki Jimbo, Rie Aoki, Shigeta Fujitani, Masahiko Ichijo, Masato Inoue, Keigo Shigeta, Yoshifumi Miyauchi, Yu Sakai, Hideki Arakawa, Yoshinobu Otsuka, Kenichi Ariyada, Yoshiaki Kuroshima, Takahisa Fuse, Y Source Type: research

Endovascular Therapy for Acute Ischemic Stroke in Patients with Large-Vessel Occlusion due to Atherosclerotic Stenosis
This study aimed to evaluate the differences in clinical results between the two subtypes using data from a multicenter prospective registry (RESCUE-Japan Registry 2).
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2021 Category: Neurology Authors: Manabu Shirakawa, Hidetoshi Matsukawa, Nobuyuki Sakai, Hiroshi Yamagami, Kanta Tanaka, Hirotoshi Imamura, Yasushi Matsumoto, Masataka Takeuchi, Hiroto Kageyama, Kazutaka Uchida, Takeshi Morimoto, Shinichi Yoshimura Source Type: research

Cost-Effectiveness Analysis of Percutaneous Patent Foramen Ovale Closure Preventing Secondary Ischemic Stroke in Japan
Cryptogenic ischemic stroke is a type of ischemic stroke for which the mechanism of onset and etiology cannot be explained or specified by any known mechanisms/factors. The possible involvement of patent foramen ovale (PFO) in the etiology of cryptogenic ischemic stroke has been reported.1 It was previously reported that occult atrial fibrillation and PFO were embolic sources that caused cryptogenic ischemic stroke.2 PFO is an opening formed during the course of fetal atrial septum development. Usually, it closes spontaneously after birth; however, PFO remains patent after maturation to adulthood.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Sachie Inoue, Ataru Igarashi, Yasuyuki Iguchi, Teiji Akagi Source Type: research

Analyzing Cost-Effectiveness of Allocating Neurointerventionist for Drive and Retrieve System for Patients with Acute Ischemic Stroke
The cost of stroke treatment accounts for approximately 6% of Japan's national medical expenditure,1 and stroke is the second most common condition, after dementia, that results in a requirement for long-term care. Thus, stroke has a significant impact on society.2 Cerebral infarction accounts for 60% or more of stroke cases.3 Systematic provision of highly equitable and efficient treatment for cerebral infarction is an important policy issue, such as the enactment of the Stroke and Cardiovascular Disease Control Act in December 2018 in Japan, as part of an effort to enhance provision of treatment for cerebral infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2021 Category: Neurology Authors: Yasuhiro Morii, Toshiya Osanai, Kensuke Fujiwara, Takumi Tanikawa, Kiyohiro Houkin, Songzi Gu, Katsuhiko Ogasawara Source Type: research

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