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Prevalence and risk factors for cerebral microbleeds in elderly Chinese patients with arteriosclerotic cardiovascular diseases: A single-center study
The objective of the study was to explore the prevalence and risk factors of cerebral microbleeds (CMBs) in elderly ( ≥ 65 years old) Chinese people with ASCVD.
Source: Journal of Stroke and Cerebrovascular Diseases - July 22, 2023 Category: Neurology Authors: Yuhui Chen, Fang Liu, Juan Chen, Dongdong Wu, Jing He, Min Chen, Yinhong Liu Source Type: research

Association between remnant cholesterol and subclinical carotid atherosclerosis among Chinese general population in health examination
Remnant cholesterol (RC) was associated with carotid atherosclerosis in patients with clinical settings. But the value of RC as a risk management indicator for subclinical carotid atherosclerosis in health examination has not been fully determined.
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2023 Category: Neurology Authors: Nimei Zeng, Yu'e Shen, Yuan Li, Yun Wang Source Type: research

Analysis of carotid plaque risk factors in a population at high risk of stroke in Yubei District, Chongqing, China
Stroke is a condition marked by a high rate of morbidity, mortality, and impairment that is brought on by the rapid rupture of blood vessels in the brain or the obstruction of blood vessels that prevent blood from reaching the brain.1 The World Health Organization (WHO) lists the top 10 causes of mortality, with stroke coming in at number two. More than 6 million people worldwide lose their lives to stroke each year, with about 2 million of those deaths reported in China. Incidence of stroke is also higher in China than in Western populations.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2023 Category: Neurology Authors: Yujia Zou, Xiaohui Zhang, Xiaoqing Bu, Ziyan Zhang, Yi Wu, Yanni Ren, Lihong Mu Source Type: research

A novel report of Cys1298Gly mutation in exon 24 of NOTCH3 gene in a Chinese family with CADASIL
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common monogenic hereditary small cerebral vessel disease, which is caused by mutation of the neurogenic locus notch homolog protein 3 gene (NOTCH3). The exon 24 encodes EGF-like repeats, variants on this exon are rare. Here, we report a novel heterozygous variant c.3892 T>G (p. Cys1298Gly) on exon 24 of NOTCH3 gene in a 57-year-old Chinese woman.
Source: Journal of Stroke and Cerebrovascular Diseases - June 7, 2023 Category: Neurology Authors: Jinghan Hu, Jing Qian, Zhihui Che, Bin Tang, Yan Li, Qiang Gong, Xianzhen Lu Tags: Case Report Source Type: research

CYP metabolic pathway related gene polymorphism increases the risk of embolic and atherothrombotic stroke and vulnerable carotid plaque in southeast China
To investigate the association of CYP metabolic pathway-related genetic polymorphisms with the susceptibility to ischemic stroke and stability of carotid plaque in southeast China.
Source: Journal of Stroke and Cerebrovascular Diseases - May 28, 2023 Category: Neurology Authors: Minjie Shao, Youbing Mao, Qing Hong, Xinchun Jin, Haibo Cai, Xingyang Yi Source Type: research

Association of CASZ1 genetic variants with stroke risk in the Chinese population
Stroke is a heterogeneous disease with multiple etiologies, placing a heavy burden on the world. Our purpose was to clarify the association between CASZ1 genetic variants and stroke risk in the Chinese population.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2023 Category: Neurology Authors: Fan Zhang, Chuanyi Fu, Yidong Deng, Mao Zhang, Hao Peng, Wenan Li, Jian Zhong, Qing Zhou, Li Huang, Shuli Xiao, Jiannong Zhao Source Type: research

Red blood cell distribution width to platelet ratio predicts early neurological deterioration in acute ischemic stroke patients receiving intravenous thrombolysis
Stroke is a disease that seriously threatens human health, with high incidence, a high disability rate and high mortality.1 –4 The occurrence rate of stroke ranks second in China, and stroke is a major contributor to disability and the main cause of death in China.1,2,4 Stroke patients suffer from not only neurological dysfunction but also serious social and psychological obstacles, which seriously affect their quality of life and place a massive economic burden on their families and society.1,5,6 Acute ischemic stroke (AIS) is the most common type of stroke, accounting for approximately 70% of the stroke cases in China.
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2023 Category: Neurology Authors: Min Jiang, Jun Shen, Bilal Muhammad, Deqin Geng Source Type: research

Association of pre-stroke frailty and health-related factors with post-stroke functional independence among community-dwelling Chinese older adults
This study aims to evaluate pre-stroke frailty status and health-related factors associated with functional independence among community-dwelling Chinese older adults.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2023 Category: Neurology Authors: Qi Zhang, Xi Gao, Jia Huang, Qiurong Xie, Yanxin Zhang Source Type: research

Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study
Stroke is China's main cause of mortality and years of life lost. With the aging population and increasing urbanization, stroke incidence has risen in China.1 Ischemic stroke (IS) is a multifactorial and multigenic disease that develops when blood supply to a specific part of the brain is disrupted or diminished, generally due to a thrombus. Although there are advancements in recanalization therapy, treatment options for stroke are still limited.2 Identifying genetic variants related to the onset risk of IS could contribute to understanding its pathogenesis and further developing innovative strategies for managing and prev...
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2023 Category: Neurology Authors: Yuye Wang, Luying Qiu, Wenjuan Jiang, Meilin Chen, Zhiyi He, Yanzhe Wang, Shumin Deng Source Type: research

CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage
Many studies have shown that cytochrome P450 (CYP) gene polymorphisms are usually associated with an increased risk of cardiovascular and cerebrovascular diseases. To explore the association of CYP2C8 and CYP2J2 gene polymorphisms with hypertensive intracerebral hemorrhage (HICH) in the Han Chinese population.
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2022 Category: Neurology Authors: Yue Li, Cuiping You, Zhenchuan Liu, Feng He, Fuchun Zhao, Xiaojie Song, Zhongxiang Xie, Shuai Wei, Yongfang Yang, Hongyan Wei, Fengyuan Che, Jixu Yu Source Type: research

Relationship between CYP2C19*2, *3 gene polymorphism and the recurrence in ischemic stroke patients treated with clopidogrel in China: A meta-analysis
The relationship between CYP2C19 *2,*3 gene variants and the recurrence in ischemic stroke patients treated with clopidogrel is still controversial according to the available published literature. To evaluate correlations between  CYP2C19 *2,*3 gene variants, metabolic typing according to *2, *3 SNPs (the polymorphism of rs4244285, rs4986893) and stroke recurrence, we performed this study through meta-analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2022 Category: Neurology Authors: Yu Yan, Ruixiao Hao, Xiuyuan Zhao, Xiaoshuang Xia, Lin Wang, Xin Li Source Type: research

Perceptions on basilar artery occlusion management in China versus other countries: Analysis of the after the BEST of BASICS (ABBA) survey
This study aimed to understand regional variation in physicians' perceptions towards the treatment of BAO as stratified by physician respondents from China versus outside China, prior to the publication of studies demonstrating a benefit of EVT for BAO.
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2022 Category: Neurology Authors: Xiaochuan Huo, Piers Klein, Raynald, Brian Drumm, Yimin Chen, Muhammad M. Qureshi, Wouter J. Schonewille, Xinfeng Liu, Wei Hu, Xunming Ji, Chuanhui Li, Yuyou Zhu, Mohamad Abdalkader, Daniel Strbian, Urs Fischer, Volker Puetz, Fana Alemseged, Hiroshi Yama Source Type: research

Association Between Intracranial Pulsatility and White Matter Hyperintensities in Asymptomatic Intracranial Arterial Stenosis: A Population-Based Study in Shandong, China
The effects of increased intracranial pulsatility on the severity of white matter hyperintensities (WMH) in participants with asymptomatic intracranial arterial stenosis (aICAS) remain uncertain. We aimed to investigate whether an increased pulsatility index (PI) is associated with WMH volume (WMHV) in individuals with aICAS.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2022 Category: Neurology Authors: Yuanyuan Zhao, Liang Dang, Xue Tian, Meilan Yang, Ming Lv, Qinjian Sun, Yifeng Du Source Type: research

Hypercoagulability of COVID-19 and Neurological Complications: A Review
The SARS-CoV-2 virus, which causes Coronavirus disease 2019 (COVID-19), has resulted in millions of worldwide deaths. When the SARS-CoV-2 virus emerged from Wuhan, China in December 2019, reports of patients with COVID-19 revealed that hospitalized patients had acute changes in mental status, cognition, and encephalopathy. Neurologic complications can be a consequence from overall severity of the systemic infection, direct viral invasion of the SARS-CoV-2 virus in the central nervous system, and possible immune mediated mechanisms.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2021 Category: Neurology Authors: Patrick Moore, Fatema Esmail, Shuai Qin, Sucha Nand, Stephanie Berg Tags: Review Article Source Type: research

Factors Associated with Post-Stroke Depression in Chinese Stroke Survivors
To explore the relationship between participation self-efficacy, sociodemographic and clinical characteristics, and post-stroke depression in stroke survivors and provide insights into the development of rehabilitation programmes.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2021 Category: Neurology Authors: Janita P C Chau, Suzanne H S Lo, Jie Zhao, Kai Chow Choi, Simon K Y Lam, Laveeza Butt, David R Thompson Source Type: research

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