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34. Modulation of cortical activity by botulinum toxin type a in patients with post-stroke arm spasticity
Conclusion: Study of 2 age-matched groups with mild and severe weakness demonstrated different effect of BoNT-lowered spasticity on motor system engagement. Group A during movement imagery at maximum BoNT effect manifested deactivation of visual and default mode system, perhaps a change from visual to kinesthetic imagery, with cerebellum participating. Group B during movement also manifested motor pattern normalization, especially reduced activation extent.Supported by IGA MZ CR NT13575.
Source: Clinical Neurophysiology - April 7, 2014 Category: Neuroscience Authors: P. Hluštík, T. Veverka, P. Hok, Z. Tüdös, P. Otruba, A. Krobot, P. Kaňovský Tags: Society Proceedings Source Type: research

47. Botulinum toxin for the upper limb after stroke: Comparison between incobotulinumtoxin A, botulinum toxin drug free of complexing proteins, and conventional botulinum toxin formulation. A preliminary study
Botulinum toxin type A (BoNT/A) provides a valuable tool in the multi-modal treatment of spasticity. Incobotulinumtoxin A (InBoNT/A) is a highly purified BoNT/A agent, free of any complexing clostridial proteins.Clinical experience suggests that InBoNT/A is identical from efficacy, duration of therapeutic effect and tolerability profile. Our aim was to compare the effect of the CBoNT/A vs InBoNT/A on spasticity of the upper limb, evaluated with Modificated Aswhort Scale (MAS), and on amplitude of compound motor action potentials (CMAP) of biceps muscle in patients after brain stroke. A randomized, double-blind, parallel-gr...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: C. Cesaretti, A. Grippo, A. Vettori, T. Atzori, C. Baldini, C. Falsini, M. Martini, R. Carrai, A. Pizzi Tags: Society Proceedings Source Type: research