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Acute head- and gaze deviation, facial asymmetry and anarthria mimicking stroke, caused by short circuit in deep brain stimulation
We report here the case of a patient with acute onset of head- and gaze deviation, anarthria, and facial asymmetry who received intravenous thrombolysis for suspected cerebral ischemia and was subsequently found to have a causal short circuit of a DBS electrode.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 5, 2022 Category: Neurology Authors: Nils Schr öter, Anna Hager, Alexander Rau, Horst Urbach, Volker A. Coenen, Michel Rijntjes Source Type: research

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models of stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted the closely related pedunculopontine nucleus in patients with Parkinson ’s disease as a therapy for gait dysfunction, with mixed reported outcomes. Recent studies suggest that optimizing the MLR target could improve its effectiveness.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 27, 2021 Category: Neurology Authors: Stephano J. Chang, Andrea J. Santamaria, Francisco J. Sanchez, Luz M. Villamil, Pedro Pinheiro Saraiva, Francisco Benavides, Yohjans Nunez-Gomez, Juan P. Solano, Ioan Opris, James D. Guest, Brian R. Noga Source Type: research

Barriers and Opportunities of Cortical Stimulation via Cerebral Venous Approach
Brain stimulation technologies, both invasive and non-invasive, have been successful in acquiring FDA approval for several indications within neuropsychiatry to include depression, Parkinson ’s disease, and others. Unfortunately, despite extensive testing, brain stimulation has failed to be part of the clinical toolbox for treatment of stroke or brain injury. Epidural stimulation showed promise in early stages of validation but failed in phase III studies with a major limitation of de layed timing of intervention(1).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 22, 2019 Category: Neurology Authors: Ali Alawieh, L.Fernando Gonzalez, Wuwei Feng Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Short Circuit in Deep Brain Stimulation for Parkinson's Disease Mimicking Stroke
To the Editor:
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - August 20, 2016 Category: Neurology Authors: Niels Allert, Marta Reyes Santana, Hans Karbe Source Type: research

Does Transcranial Direct Current Stimulation Actually Deliver DC Stimulation: Response to Letter to the Editor
Transcranial direct current stimulation (tDCS) is a common form of transcranial electric stimulation (tES). It delivers constant, low intensity currents to the brain through spongy type electrodes on the scalp [1]. tDCS has been explored for producing behavioral changes and cognitive enhancement in healthy individuals [2]. Furthermore, tDCS may be helpful in attenuating symptoms of neurological disorders such as Parkinson's disease, Alzheimer's disease, schizophrenia, and stroke [3,4]. There are currently no FDA approved indications for its clinical use.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 2, 2016 Category: Neurology Authors: Yousef Salimpour, Kelly A. Mills, Zhikui Wei, Phan Q. Duy, William S. Anderson Source Type: research

DBS in critical care conditions
The efficacy of Deep Brain Stimulation (DBS) is well established in the treatment of chronic neurological diseases such as Parkinson's disease and primary dystonia. Emerging indications include, refractory epilepsy, chronic cluster headache, major depression, obsessive compulsive disorder, disruptive behaviour and Gilles de la Tourette syndrome. Nevertheless in selected cases DBS may be a treatment option in acute neurological disease or sudden dramatic worsening of pre-existing diseases in emergency conditions such as status dystonicus (SD) and post-stroke conditions.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, R. Cordella, G. Messina, C.E. Marras, G. Zorzi, D. Caldiroli, A. Franzini Source Type: research

Single electrode DBS through motor thalamus and caudal zona incerta for the treatment of tremor syndromes
Both nucleus ventralis lateralis (VL) and subthalamic nucleus (STN) DBS are effective in the treatment of essential tremor and Parkinson's disease tremor. Complex tremor syndromes may present the overlapping of different clinical aspects (at rest, postural and kinetic) and can be associated to syndromic forms (dystonic, cerebellar, spastic), but also to different etiologies (following brain injury or stroke). In these cases DBS does not always guarantees an effective outcome. A recent study proposed single electrode DBS of both ventralis oralis posterior (vop) thalamic nucleus and caudal Zona Incerta (cZI) for the treatmen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, G. Messina, R. Cordella, F. Penner, A. Franzini Source Type: research

Eyelid Myokymia in an Older Subject After Repetitive Sessions of Anodal Transcranial Direct Current Stimulation
Non-invasive brain stimulation techniques have developed into useful tools to study brain functions, like motor learning , physiological changes of the brain like during healthy aging or pathological conditions (e.g., stroke, parkinson, tinnitus, among others) . Furthermore they are more and more applied and evaluated as therapeutic tools to treat neuropsychiatric diseases . The evolution of these techniques emphasizes the importance to report possible adverse effects. Here, we present a case with occurrence of monocular eyelid myokymia after repetitive application of anodal transcranial direct current stimulation (tDCS) to the motor cortex.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 5, 2012 Category: Neurology Authors: M. Wessel, M. Zimerman, J.E. Timmermann, F.C. Hummel Tags: Letters to the Editor Source Type: research