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Source: Pediatric Neurology
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Total 48 results found since Jan 2013.
Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research
Diffusion-Weighted Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children With Moyamoya Without Stroke or Silent Infarct
Moyamoya is a disease with progressive cerebral arterial stenosis leading to stroke and silent infarct. Diffusion-weighted magnetic resonance imaging (dMRI) studies show that adults with moyamoya have significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) compared with controls, which raises concern for unrecognized white matter injury. Children with moyamoya have significantly lower FA and higher MD in their white matter compared with controls.
Source: Pediatric Neurology - March 15, 2023 Category: Neurology Authors: Banu Ahtam, Marina Solti, Justin M. Doo, Henry A. Feldman, Rutvi Vyas, Fan Zhang, Lauren J. O'Donnell, Yogesh Rathi, Edward R. Smith, Darren Orbach, Alfred P. See, P. Ellen Grant, Laura L. Lehman Tags: Research Paper Source Type: research
Diffusion Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children with Moyamoya without Stroke or Silent Infarct
Moyamoya is a disease with progressive cerebral arterial stenosis leading to stroke and silent infarct. Diffusion magnetic resonance imaging (dMRI) studies show that adults with moyamoya have significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) compared to controls. This raises concern for unrecognized white matter injury. Children with moyamoya have significantly lower FA and higher MD in their white matter compared to controls.
Source: Pediatric Neurology - March 15, 2023 Category: Neurology Authors: Banu Ahtam, Marina Solti, Justin M. Doo, Henry A. Feldman, Rutvi Vyas, Fan Zhang, Lauren J. O ’Donnell, Yogesh Rathi, Edward R. Smith, Darren Orbach, Alfred P. See, P. Ellen Grant, Laura L. Lehman Tags: Research Paper Source Type: research
Before blaming SARS-CoV-2 for cerebrovascular disease in children, all differentials need to be ruled out
We read with interest the article by Spanelova et al. about four pediatric patients with cerebrovascular complications after a putative SARS-CoV-2 infection [1]. Patient-1 was diagnosed with subdural hematoma (SDH) and meningitis, patient-2 with cerebral vasculitis, patient-3 with lacunar stroke, and patient-4 with venous sinus thrombosis (VST) with haemorrhage [1]. It was concluded that SARS-CoV-2 infections in children can be complicated by cerebro-vascular disease [1]. The study is promising but raises concerns that should be discussed.
Source: Pediatric Neurology - February 14, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research
Neonatal arterial ischemic stroke secondary to carotid artery dissection: a case report and systematic literature review
Carotid artery (CA) dissection is a rare aetiology of neonatal arterial ischemic stroke (NAIS). Diagnosis is challenging due to low level of suspicion and difficult interpretation of neonatal vascular studies.
Source: Pediatric Neurology - October 28, 2022 Category: Neurology Authors: Laura Baggio, Margherita Nosadini, Maria Federica Pelizza, Jacopo Norberto Pin, Anna Zarpellon, Clarissa Tona, Giorgio Perilongo, Paolo Simioni, Irene Toldo, Giacomo Talenti, Stefano Sartori Tags: Research Paper Source Type: research
Longitudinal Stability of Spatial Inattention in Children with Perinatal Stroke
This study is a longitudinal analysis of children with perinatal infarcts, with the goals of determining the pattern of inattention found in children with both left and right hemisphere lesions, and whether or not this pattern shows signs of change over time.
Source: Pediatric Neurology - January 22, 2021 Category: Neurology Authors: Jessica Kriksciun, Caitlin Knight, Doris Trauner Tags: Research Paper Source Type: research
Sirolimus Treatment in Sturge-Weber Syndrome
Sturge-Weber syndrome is a rare neurovascular disorder associated with capillary malformation, seizures, cognitive impairments, and stroke-like episodes (SLE), arising from a somatic activating mutation in GNAQ. Studies suggest this mutation may cause hyperactivation of the mTOR pathway. Sirolimus is an mTOR inhibitor studied in other vascular anomalies, and a potentially promising therapy in Sturge-Weber syndrome.
Source: Pediatric Neurology - November 2, 2020 Category: Neurology Authors: Alison J. Sebold, Alyssa M. Day, Joshua Ewen, Jack Adamek, Anna Byars, Bernard Cohen, Eric H. Kossoff, Tomoyuki Mizuno, Matthew Ryan, Jacqueline Sievers, Lindsay Smegal, Stacy J. Suskauer, Cameron Thomas, Alexander Vinks, T. Andrew Zabel, Adrienne M. Hamm Tags: Research Paper Source Type: research
Defining a Pediatric Stroke Center
Stroke was once recognized so infrequently in children that it was considered a medical curiosity, and until relatively recently, our understanding of the nature of cerebrovascular disorders in children was somewhat rudimentary. But we now know that cerebrovascular disorders are relatively common among children,1 and with the advent of less invasive diagnostic studies and more targeted treatments, stroke is now recognized as a very important clinical condition in children.
Source: Pediatric Neurology - August 11, 2020 Category: Neurology Authors: E. Steve Roach, Timothy Bernard, M.D. Gabrielle deVeber Source Type: research
Cancer and Tumor-Associated Childhood Stroke: Results from the International Pediatric Stroke Study
This study sought to evaluate cancer/tumor-associated childhood ischemic stroke in a multinational pediatric stroke registry.
Source: Pediatric Neurology - June 8, 2020 Category: Neurology Authors: Lisa R. Sun, Alexandra Linds, Mukta Sharma, Mubeen Rafay, Sudhakar Vadivelu, Sarah Lee, Leonardo R. Brand ão, Brian Appavu, Jeremie H. Estepp, Juliette Hukin, Sahar M.A. Hassanein, Anthony Chan, Lauren A. Beslow, International Pediatric Stroke Study Grou Tags: Research Paper Source Type: research
Rapid Sequence MRI Protocol in the Evaluation of Pediatric Brain Attacks
The objective of our study was to evaluate the clinical utility of rapid sequence magnetic resonance imaging (MRI) utilizing diffusion weighted imaging (DWI) and fluid attenuated inversion recovery (FLAIR) sequences in children with acute ischemic strokes and non-stroke brain attacks.
Source: Pediatric Neurology - December 26, 2019 Category: Neurology Authors: Gracia De Jong, Nirupama Kannikeswaran, Amy DeLaroche, Ahmad Farooqi, Lalitha Sivaswamy Tags: Research Paper Source Type: research
Arterial ischemic stroke secondary to cardiac disease in neonates and children
To describe risk factors for peri-procedural and spontaneous arterial ischemic stroke (AIS) in children with cardiac disease.
Source: Pediatric Neurology - June 26, 2019 Category: Neurology Authors: M.G. Chung, K.P. Guilliams, J.L. Wilson, L.A. Beslow, M.M. Dowling, N.R. Friedman, S.M.A. Hassanein, R. Ichord, L.C. Jordan, M.T. Mackay, M.F. Rafay, M. Rivkin, M. Torres, D. Zafeiriou, G. deVeber, C.K. Fox, International Pediatric Stroke Study Investigat Tags: Research Paper Source Type: research
What is the role of mechanical thrombectomy in childhood stroke?
Like adults, most children have lifelong morbidity following stroke. Revascularization therapies such as intravenous tissue plasminogen activator and mechanical thrombectomy may be options to decrease this morbidity in selected children, although currently there are no evidence-based recommendations to guide treatment. The utility and safety of mechanical thrombectomy in childhood stroke is unknown due to that lack of safety trials, case-controlled trials, and comprehensive retrospective studies.
Source: Pediatric Neurology - January 16, 2019 Category: Neurology Authors: Megan Barry, Danial Hallam, Timothy J. Bernard, Catherine Amlie-Lefond Tags: Topical Review Source Type: research
Stroke in pediatric bacterial meningitis: Population-based epidemiology
Bacterial meningitis is a severe infection of the nervous system with a high complication rate including stroke. The purpose of this study is to assess the incidence, risk factors, patterns and outcomes in pediatric meningitis complicated by stroke.
Source: Pediatric Neurology - September 21, 2018 Category: Neurology Authors: Mary Dunbar, Hely Shah, Siddharth Shinde, Joseph Vayalumkal, Otto G. Vanderkooi, Xing-Chang Wei, Adam Kirton Tags: Original Articles Source Type: research
Incidence of and Associated Factors Related to Epilepsy in Perinatal Arterial Ischemic Stroke Survivors
We examined studies on perinatal or neonatal patients ( ≤ 28 days of life) with arterial ischemic strokes in which the development of epilepsy was reported.
Source: Pediatric Neurology - September 20, 2018 Category: Neurology Authors: Abbas Rattani, Jaims Lim, Akshitkumar M Mistry, Marc A Prablek, Steven G Roth, Lori C Jordan, Chevis N Shannon, Robert P Naftel Source Type: research
In-Hospital Pediatric Stroke Alert Activation
Pediatric stroke alerts or “code strokes” allow for rapid evaluation, imaging and treatment of children presenting with stroke-like symptoms. In a previous study of emergency department-initiated pediatric stroke alerts, 24% of children had confirmed strokes. The purpose of this study was to characterize in-hospital pedia tric stroke alerts.
Source: Pediatric Neurology - August 10, 2018 Category: Neurology Authors: Megan Barry, Truc M. Le, Melissa C. Gindville, Lori C. Jordan Tags: Original Articles Source Type: research
