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Source: Stroke
Procedure: Perfusion
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Total 155 results found since Jan 2013.
Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning Clinical Sciences
Background and Purpose—Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume.Methods—Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep) to predict final imaging outcome. A total of 222 patients were included, of which 187 were treated with...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Treatment, Quality and Outcomes, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research
Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy Clinical Sciences
Conclusions—The majority of patients with CTP imaging in the ESCAPE trial had penumbral patterns, which were associated with better outcomes overall. Patients with penumbra treated with endovascular therapy had the greatest odds of good functional outcome. Nonpenumbral patients were much less likely to achieve good outcomes.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert Wannamaker, Taurian Guinand, Bijoy K. Menon, Andrew Demchuk, Mayank Goyal, Donald Frei, Aditya Bharatha, Tudor G. Jovin, Jai Shankar, Timo Krings, Blaise Baxter, Christine Holmstedt, Richard Swartz, Dar Dowlatshahi, Richard Chan, Donatella Tampieri Tags: Ischemic Stroke Original Contributions Source Type: research
Modified Thrombolysis in Cerebral Infarction 2C/Thrombolysis in Cerebral Infarction 3 Reperfusion Should Be the Aim of Mechanical Thrombectomy Clinical Sciences
Conclusions—Combining mTICI 2C and TICI 3 grades helps to determine a subgroup of patients achieving better functional outcomes than mTICI 2B patients. Achieving mTICI 2C/3 reperfusion should be the new aim of mechanical thrombectomy for anterior circulation LVO.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Cyril Dargazanli, Robert Fahed, Raphael Blanc, Benjamin Gory, Julien Labreuche, Alain Duhamel, Gaultier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Mikael Mazighi, Arturo Consoli, Michel Piotin, Bertrand Lapergue Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection Basic Sciences
Conclusions—Promoting microvascular reperfusion by protecting vasculature can secondarily reduce parenchymal ROS formation and provide neuroprotection. The model presented can be used to directly assess pharmacological end points postulated in brain parenchyma and vasculature in vivo.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Aslihan Taskiran-Sag, Muge Yemisci, Yasemin Gursoy-Ozdemir, Sefik Evren Erdener, Hulya Karatas, Deniz Yuce, Turgay Dalkara Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research
Boosted Tree Model Reforms Multimodal Magnetic Resonance Imaging Infarct Prediction in Acute Stroke Clinical Sciences
Background and Purpose—Stroke imaging is pivotal for diagnosis and stratification of patients with acute ischemic stroke to treatment. The potential of combining multimodal information into reliable estimates of outcome learning calls for robust machine learning techniques with high flexibility and accuracy. We applied the novel extreme gradient boosting algorithm for multimodal magnetic resonance imaging–based infarct prediction.Methods—In a retrospective analysis of 195 patients with acute ischemic stroke, fluid-attenuated inversion recovery, diffusion-weighted imaging, and 10 perfusion parameters were derived from...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Michelle Livne, Jens K. Boldsen, Irene K. Mikkelsen, Jochen B. Fiebach, Jan Sobesky, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research
Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke Clinical Sciences
This study aimed to assess how the ischemic core measured by perfusion computed tomography (CTP) was affected by the delay and dispersion effect.Methods—Ischemic stroke patients having CTP performed within 6 hours of onset were included. The CTP data were processed twice, generating standard cerebral blood flow (sCBF) and delay- and dispersion-corrected CBF (ddCBF), respectively. Ischemic core measured by the sCBF and ddCBF was then compared at the relative threshold
Source: Stroke - March 26, 2018 Category: Neurology Authors: Longting Lin, Andrew Bivard, Timothy Kleinig, Neil J. Spratt, Christopher R. Levi, Qing Yang, Mark W. Parsons Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research
Thalamic Diaschisis in Acute Ischemic Stroke Clinical Sciences
Background and Purpose—Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, which does not directly affect the thalamus.Methods—One hundred twenty-four patients with middle cerebral artery infarction were selected from a prospectively acquired cohort of 1644 patients who underwent multiparametric computed tomography (CT), including CT perfusion for suspected stroke. Two blinded read...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Paul Reidler, Kolja M. Thierfelder, Matthias P. Fabritius, Wieland H. Sommer, Felix G. Meinel, Franziska Dorn, Frank A. Wollenweber, Marco Duering, Wolfgang G. Kunz Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research
Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke Clinical Sciences
Conclusions—Compared with target mismatch patients, those with the malignant profile experience faster infarct growth and a steeper decline in the odds of functional independence, with longer delays between baseline imaging and reperfusion. However, this does not exclude the possibility of treatment benefit in patients with a malignant profile.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Jenny P. Tsai, Michael Mlynash, Soren Christensen, Stephanie Kemp, Sun Kim, Nishant K. Mishra, Christian Federau, Raul G. Nogueira, Tudor G. Jovin, Thomas G. Devlin, Naveed Akhtar, Dileep R. Yavagal, Roland Bammer, Matus Straka, Gregory Zaharchuk, Michael Tags: Revascularization, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window Brief Report
Conclusions—Of all patients with acute ischemic stroke presenting to a single comprehensive stroke center, 1.7% of patients qualified for DAWN clinical trial enrollment with an additional 0.6% to 1% qualifying for the DEFUSE-3 trial. These data predict an increase in thrombectomy utilization with important implications for comprehensive stroke center resource optimization and stroke systems of care.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Ashutosh P. Jadhav, Shashvat M. Desai, Cynthia L. Kenmuir, Marcelo Rocha, Matthew T. Starr, Bradley J. Molyneaux, Bradley A. Gross, Brian T. Jankowitz, Tudor G. Jovin Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Brief Reports Source Type: research
Staging Hemodynamic Failure With Blood Oxygen-Level-Dependent Functional Magnetic Resonance Imaging Cerebrovascular Reactivity Clinical Sciences
We examined the agreement between the 2 imaging modalities and hypothesized that quantitative CVR can be a surrogate imaging marker to assess hemodynamic failure.Methods—Nineteen data sets of subjects with chronic cerebrovascular steno-occlusive disease (age, 60±11 years; 4 women) and unilaterally impaired perfusion reserve on Diamox-challenged (15O-)H2O PET were studied and compared with a standardized BOLD functional magnetic resonance imaging+CO2 examination within 6 weeks (8±19 days). Agreement between quantitative CBF- and CVR-based perfusion reserve was assessed. Hemodynamic failure was staged according to PET fi...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Jorn Fierstra, Christiaan van Niftrik, Geoffrey Warnock, Susanne Wegener, Marco Piccirelli, Athina Pangalu, Giuseppe Esposito, Antonios Valavanis, Alfred Buck, Andreas Luft, Oliver Bozinov, Luca Regli Tags: Functional Magnetic Resonance Imaging (fMRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Reduced Intravoxel Incoherent Motion Microvascular Perfusion Predicts Delayed Cerebral Ischemia and Vasospasm After Aneurysm Rupture Brief Report
Conclusions—Decreased IVIM perfusion fraction f and blood flow–related parameter fD* correlate with DCI and proximal artery vasospasm development after cerebral aneurysm rupture.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Jeremy J. Heit, Max Wintermark, Blake W. Martin, Guangming Zhu, Michael P. Marks, Greg Zaharchuk, Robert L. Dodd, Huy M. Do, Gary K. Steinberg, Maarten G. Lansberg, Gregory W. Albers, Christian Federau Tags: Magnetic Resonance Imaging (MRI), Cerebral Aneurysm, Intracranial Hemorrhage, Aneurysm Brief Reports Source Type: research
Vulnerability to Infarction During Cerebral Ischemia in Migraine Sufferers Clinical Sciences
Conclusions—Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Alessandro Pezzini, Giorgio Busto, Marialuisa Zedde, Massimo Gamba, Andrea Zini, Loris Poli, Filomena Caria, Valeria De Giuli, Anna Maria Simone, Rosario Pascarella, Alessandro Padovani, Marina Padroni, Roberto Gasparotti, Stefano Colagrande, Enrico Faina Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke, Vascular Disease Original Contributions Source Type: research
Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline Clinical Sciences
Background and Purpose—Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans.Methods—Patients with suspected TIA underwent acute brain perfusion imaging, and those with acute ischemia were enrolled into a prospective observational study. We collected baseline and 90-day magnetic resonance imaging, including MP-RAGE (high-resolution T1 sequence) and cognitive assessment with the Montreal Cognitive Assessment. Brain morphometry and within patient stat...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Andrew Bivard, Thomas Lillicrap, Benedicte Marechal, Carlos Garcia–Esperon, Elizabeth Holliday, Venkatesh Krishnamurthy, Christopher R. Levi, Mark Parsons Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Cognitive Impairment, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Symptomatic Intracranial Atherosclerosis With Impaired Distal Perfusion Illustrative Teaching Cases
Source: Stroke - December 22, 2017 Category: Neurology Authors: Katarina Dakay, Shadi Yaghi Tags: Cerebrovascular Disease/Stroke Illustrative Teaching Case Source Type: research
Factors Associated With Focal Computed Tomographic Perfusion Abnormalities in Supratentorial Transient Ischemic Attacks Clinical Sciences
Conclusions—Supratentorial TIAs are often associated with FPA in CTP, even after symptom resolution. FPAs are frequent in severe TIAs and those associated with cardioembolism or specific arterial pathologies. These findings can help clinicians in accurate diagnosis of TIA and its underlying mechanisms.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Ivo A. Meyer, Carlo W. Cereda, Pamela N. Correia, Jean-Baptiste Zerlauth, Francesco Puccinelli, David C. Rotzinger, Michael Amiguet, Philippe Maeder, Reto A. Meuli, Patrik Michel Tags: Computerized Tomography (CT), Transient Ischemic Attack (TIA) Original Contributions Source Type: research
