Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline [Clinical Sciences]
Background and Purpose—Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans.Methods—Patients with suspected TIA underwent acute brain perfusion imaging, and those with acute ischemia were enrolled into a prospective observational study. We collected baseline and 90-day magnetic resonance imaging, including MP-RAGE (high-resolution T1 sequence) and cognitive assessment with the Montreal Cognitive Assessment. Brain morphometry and within patient statistical analysis were performed to identify changes between baseline and 90-day imaging and clinical assessments.Results—Fifty patients with TIA with acute perfusion lesions were studied. All patients experienced a decrease in global cortical gray matter (P=0.005). Patients with anterior circulation TIA (n=31) also had a significant reduction in the volume of the pons (P
Source: Stroke - Category: Neurology Authors: Andrew Bivard, Thomas Lillicrap, Benedicte Marechal, Carlos Garcia–Esperon, Elizabeth Holliday, Venkatesh Krishnamurthy, Christopher R. Levi, Mark Parsons Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Cognitive Impairment, Transient Ischemic Attack (TIA) Original Contributions Source Type: research