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Validity of Acute Stroke Lesion Volume Estimation by Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomographic Score Depends on Lesion Location in 496 Patients With Middle Cerebral Artery Stroke Clinical Sciences
Conclusions— ASPECTS has limitations when lesion location is not considered. Identification of patients with malignant profile by DWI-ASPECTS may be unreliable. ASPECTS may be a useful tool for the evaluation of noncontrast computed tomography. However, if MRI is used, ASPECTS seems dispensable because lesion volume can easily be quantified on DWI maps.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Schroder, J., Cheng, B., Ebinger, M., Kohrmann, M., Wu, O., Kang, D.-W., Liebeskind, D. S., Tourdias, T., Singer, O. C., Christensen, S., Campbell, B., Luby, M., Warach, S., Fiehler, J., Fiebach, J. B., Gerloff, C., Thomalla, G., on behalf of the STIR and Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Spot Sign on 90-Second Delayed Computed Tomography Angiography Improves Sensitivity for Hematoma Expansion and Mortality: Prospective Study Clinical Sciences
Conclusions— We demonstrate improved sensitivity for predicting hematoma expansion and poor outcome by adding a 90-second delayed CTA, which may enhance selection of patients who may benefit from hemostatic therapy.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Ciura, V. A., Brouwers, H. B., Pizzolato, R., Ortiz, C. J., Rosand, J., Goldstein, J. N., Greenberg, S. M., Pomerantz, S. R., Gonzalez, R. G., Romero, J. M. Tags: Intracerebral Hemorrhage Clinical Sciences Source Type: research

Hemorrhagic Stroke and Cerebral Paragonimiasis Brief Reports
Conclusions— Hemorrhagic stroke typically occurred during the acute stage and in the early stages of further Paragonimus migration. Delay of treatment increased the risk of initial and recurrent stroke.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Xia, Y., Ju, Y., Chen, J., You, C. Tags: Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging, Primary and Secondary Stroke Prevention, Risk Factors for Stroke Brief Reports Source Type: research

Morphological, Hemodynamic, and Clinical Independent Risk Factors for Anterior Communicating Artery Aneurysms Clinical Sciences
Conclusions— The risk of ACoA aneurysm formation is determined by several independent clinical, morphological, and hemodynamic factors. The strongest independent risk factors include smoking, asymmetry of A1 segments >40%, low blood flow pulsatility, and the angle between A1 and A2 segments ≤100°.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Kaspera, W., Ładziłski, P., Larysz, P., Hebda, A., Ptaszkiewicz, K., Kopera, M., Larysz, D. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Computed Tomographic Angiography and Cerebral Blood Volume Can Predict Final Infarct Volume and Outcome After Recanalization Clinical Sciences
Conclusions— CTASI and CBV were better at predicting 24-hour infarct and outcome than NECT. Appropriate advanced imaged guided selection may improve outcomes in large-vessel stroke treated with the newest techniques.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Lum, C., Ahmed, M. E., Patro, S., Thornhill, R., Hogan, M., Iancu, D., Lesiuk, H., dos Santos, M., Dowlatshahi, D., on behalf of the Ottawa Stroke Research Group (OSRG) Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Angioplasty and Stenting Clinical Sciences Source Type: research

Persistent Cognitive Impairment After Transient Ischemic Attack Clinical Sciences
Conclusions— More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.
Source: Stroke - July 28, 2014 Category: Neurology Authors: van Rooij, F. G., Schaapsmeerders, P., Maaijwee, N. A. M., van Duijnhoven, D. A. H. J., de Leeuw, F.-E., Kessels, R. P. C., van Dijk, E. J. Tags: Behavioral/psychosocial - stroke, Behavioral Changes and Stroke, Transient Ischemic Attacks Clinical Sciences Source Type: research

A New Micro-Computed Tomography-Based High-Resolution Blood-Brain Barrier Imaging Technique to Study Ischemic Stroke Brief Reports
Conclusions— The new mCT BBB imaging technique, based on the intra-arterial infusion of clinically available iopromide, allows serial quantitative visualization of poststroke BBB dysfunction in mice, with high resolution and in a sensitive manner.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Park, J.-Y., Lee, S.-K., Kim, J.-Y., Je, K.-H., Schellingerhout, D., Kim, D.-E. Tags: Animal models of human disease, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Six-Minute Magnetic Resonance Imaging Protocol for Evaluation of Acute Ischemic Stroke: Pushing the Boundaries Clinical Sciences
Conclusions— A 6-minute multimodal MR protocol with good diagnostic quality is feasible for the evaluation of patients with acute ischemic stroke and can result in significant reduction in scan time rivaling that of the multimodal computed tomographic protocol.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., Drake, K., Coull, B. M., Kidwell, C. S. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Impact of Diffusion-Weighted Imaging Alberta Stroke Program Early Computed Tomography Score on the Success of Endovascular Reperfusion Therapy Clinical Sciences
Conclusions— DWI-ASPECTS ≥5 seems to be the optimal threshold to predict favorable outcomes among patients undergoing endovascular reperfusion within 6 hours. Selected patients with a DWI-ASPECTS of <5 may still benefit when a complete reperfusion is achieved.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Inoue, M., Olivot, J.-M., Labreuche, J., Mlynash, M., Tai, W., Albucher, J.-F., Meseguer, E., Amarenco, P., Mazighi, M. Tags: Acute Stroke Syndromes, Thrombolysis Clinical Sciences Source Type: research

Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared Brief Reports
Conclusions— The most potent associations with spot sign are shared between deep and lobar ICH, suggesting that the acute bleeding process that arises in the setting of different chronic small vessel diseases shares commonalities.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Radmanesh, F., Falcone, G. J., Anderson, C. D., Battey, T. W. K., Ayres, A. M., Vashkevich, A., McNamara, K. A., Schwab, K., Romero, J. M., Viswanathan, A., Greenberg, S. M., Goldstein, J. N., Rosand, J., Brouwers, H. B. Tags: Acute Cerebral Hemorrhage, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Isolated Cortical Vein Thrombosis: Systematic Review of Case Reports and Case Series Brief Reports
Conclusions— Signs of increased intracranial pressure seem to be less common in isolated cortical vein thrombosis compared with cerebral venous and sinus thrombosis. MRI and in some cases conventional angiography are the most frequently used diagnostic modalities and anticoagulation is the most widely used therapy.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Coutinho, J. M., Gerritsma, J. J., Zuurbier, S. M., Stam, J. Tags: Cerebral Venous Thrombosis Brief Reports Source Type: research

Varying Correlation Between 18F-Fluorodeoxyglucose Positron Emission Tomography and Dynamic Contrast-Enhanced MRI in Carotid Atherosclerosis: Implications for Plaque Inflammation Brief Reports
Conclusions— The correlation between 18F-fluorodeoxyglucose positron emission tomography and dynamic contrast-enhanced MRI measurements varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. The moderate correlation shown only in symptomatic plaques indicates the presence of acute plaque inflammation with increased metabolic activity and cytokine production by inflammatory cells.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Wang, J., Liu, H., Sun, J., Xue, H., Xie, L., Yu, S., Liang, C., Han, X., Guan, Z., Wei, L., Yuan, C., Zhao, X., Chen, H. Tags: Pathophysiology, Imaging, Carotid Stenosis, Mechanism of atherosclerosis/growth factors Brief Reports Source Type: research

Cerebral Perfusion and Blood Pressure Do Not Affect Perihematoma Edema Growth in Acute Intracerebral Hemorrhage Clinical Sciences
Conclusions— Lower perihematoma CBF and BP treatment do not exacerbate edema growth. These data do not support a cytotoxic edema pathogenesis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00963976.
Source: Stroke - April 28, 2014 Category: Neurology Authors: McCourt, R., Gould, B., Gioia, L., Kate, M., Coutts, S. B., Dowlatshahi, D., Asdaghi, N., Jeerakathil, T., Hill, M. D., Demchuk, A. M., Buck, B., Emery, D., Butcher, K., on behalf of the ICH ADAPT Investigators Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Difference in Aneurysm Characteristics Between Ruptured and Unruptured Aneurysms in Patients With Multiple Intracranial Aneurysms Clinical Sciences
Conclusions— Aspect ratio ≥1.3 and irregular shape are associated with aneurysm rupture independent of aneurysm size and location, and independent of patient characteristics. Additional studies need to assess to what extent these factors increase the risks of rupture of small aneurysms in absolute terms.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Backes, D., Vergouwen, M. D. I., Velthuis, B. K., van der Schaaf, I. C., Bor, A. S. E., Algra, A., Rinkel, G. J. E. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Vertebral Artery Hypoplasia: Frequency and Effect on Cerebellar Blood Flow Characteristics Clinical Sciences
Conclusions— VAH is a frequent vascular variant that can lead to a relative regional hypoperfusion in the PICA territory. Additional research should clarify the pathophysiological role of VAH in PCI.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Thierfelder, K. M., Baumann, A. B., Sommer, W. H., Armbruster, M., Opherk, C., Janssen, H., Reiser, M. F., Straube, A., von Baumgarten, L. Tags: Brain Circulation and Metabolism, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

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