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Source: Neurocritical Care
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Total 235 results found since Jan 2013.
Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
ConclusionsSpreading depolarizations better account for the acute neuronal injury arising from brain ischemia than does the early and excessive release of glutamate.
Source: Neurocritical Care - February 22, 2022 Category: Neurology Source Type: research
Timely and Appropriate Administration of Inhaled Argon Provides Better Outcomes for tMCAO Mice: A Controlled, Randomized, and Double-Blind Animal Study
ConclusionsTimely iAr administration during ischemia showed optimal neurological outcomes and minimal infarct volumes. Moreover, an appropriate duration of argon administration was important for better neuroprotective efficacy. These findings may provide vital guidance for using argon as a neuroprotective agent and moving to clinical trials in acute ischemic stroke.
Source: Neurocritical Care - February 8, 2022 Category: Neurology Source Type: research
Ferrostatin-1 Polarizes Microglial Cells Toward M2 Phenotype to Alleviate Inflammation After Intracerebral Hemorrhage
ConclusionsOverall, our findings suggest that Fer-1 may be a novel mechanism underlying microglial M2 polarization and inflammation after ICH.
Source: Neurocritical Care - January 31, 2022 Category: Neurology Source Type: research
The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis
AbstractHyperoxemia commonly occurs in clinical practice and is often left untreated. Many studies have shown increased mortality in patients with hyperoxemia, but data on neurological outcome in these patients are conflicting, despite worsened neurological outcome found in preclinical studies. To investigate the association between hyperoxemia and neurological outcome in adult patients, we performed a systematic review and meta-analysis of observational studies. We searched MEDLINE, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov from inception to May 2020 f...
Source: Neurocritical Care - January 31, 2022 Category: Neurology Source Type: research
Correction to: Early Prediction of Malignant Edema After Successful Recanalization in Patients with Acute Ischemic Stroke
Source: Neurocritical Care - January 11, 2022 Category: Neurology Source Type: research
Relationship Between Body Temperature and Early Neurological Deterioration after Endovascular Thrombectomy for Acute Ischemic Stroke with Large Vessel Occlusion
ConclusionsIn summary, there is a J-shaped association between the maximum body temperature within 24 h after EVT and END. Moreover, the risk of END differed according to the timing of fever onset.
Source: Neurocritical Care - January 3, 2022 Category: Neurology Source Type: research
Rate of Infarct –Edema Growth on CT Predicts Need for Surgical Intervention and Clinical Outcome in Patients with Cerebellar Infarction
ConclusionsEarly infarct –edema growth rate, measured via ABC/2, is a promising biomarker for identifying the need for surgical intervention in patients with acute cerebellar infarction. Additionally, it may be used to facilitate discussions regarding patient prognosis.
Source: Neurocritical Care - December 29, 2021 Category: Neurology Source Type: research
Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke
ConclusionsIn patients with hemorrhagic stroke, nicardipine appeared to have similar efficacy as clevidipine in SBP reduction, with a more likely reduction of rebound hypertension and drug cost. This retrospective study was underpowered, which may limit these implications. Further prospective studies are warranted to confirm these results.
Source: Neurocritical Care - December 13, 2021 Category: Neurology Source Type: research
Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex
ConclusionsWe propose that the dysfunction of cerebrovascular autoregulation that occurs simultaneously with hypotension transients poses a substantial risk of SD occurrence and is not a consequence of SD. Under such circumstances, the evolving SD is not accompanied by any recognizable CBF response, which indicates a severely damaged neurovascular coupling.
Source: Neurocritical Care - December 2, 2021 Category: Neurology Source Type: research
Standardized Transfer Process for a Neurointensive Care Unit and Assessment of Patient Bounceback
ConclusionsPatients who bounceback to the neuro-ICU within 48 h had an increased length of hospital stay, had an increased length of ICU stay, and were more likely to be intubated for more than 96 h. Implementation of a standardized five-step transfer process from the neuro-ICU to a lower level of care resulted in improvement in multiple provider-rated safe ty outcomes and identification of high-risk patients but led to no difference in the patient bounceback rate or patient disposition at discharge.
Source: Neurocritical Care - November 17, 2021 Category: Neurology Source Type: research
Early Prediction of Malignant Edema After Successful Recanalization in Patients with Acute Ischemic Stroke
ConclusionsThe extent of postinterventional cerebral hyperdensities on postinterventional non-contrast-enhanced CT was associated with malignant brain edema. The Hyperdensity on CT Score could be used to predict malignant brain edema regardless of the component of postinterventional cerebral hyperdensities.
Source: Neurocritical Care - November 8, 2021 Category: Neurology Source Type: research
Deferred Consent in an Acute Stroke Trial from a Patient, Proxy, and Physician Perspective: A Cross-Sectional Survey
ConclusionsA large majority of the surveyed patients and proxies and a somewhat smaller majority of the surveyed physicians agreed with deferred consent in the ULTRA trial. Deferred consent may enable acute care trials in an acceptable manner without decreasing trust in medicine. Future research should investigate factors facilitating the responsible use of deferred consent, such as in-depth interviews, to study the minority of participants who agreed with deferred consent but still preferred immediate informed consent.
Source: Neurocritical Care - October 5, 2021 Category: Neurology Source Type: research
Development and Evaluation of a Method for Automated Detection of Spreading Depolarizations in the Injured Human Brain
ConclusionsDespite significant undersensitivity, there was no additional loss of sensitivity at high SD counts, thus ensuring that dense clusters of depolarizations of particular pathogenic potential can be detected by software and depicted to clinicians in real time and also be archived.
Source: Neurocritical Care - October 1, 2021 Category: Neurology Source Type: research
Size-Related Differences in Computed Tomography Markers of Hematoma Expansion in Acute Intracerebral Hemorrhage
ConclusionsThe prevalence of NCCT markers and their association with HE differed according to hematoma volume. Quantitative hematoma density was associated with HE, regardless of hematoma size.
Source: Neurocritical Care - September 29, 2021 Category: Neurology Source Type: research
