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Source: Heart Rhythm
Condition: Arrhythmia
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Total 46 results found since Jan 2013.
Ce-454029-4 racial disparities in the use of oral anticoagulation for atrial fibrillation by sex and within high and low stroke risk populations
Atrial fibrillation (AF) is the most common arrhythmia and is associated with an increased risk of ischemic stroke. Oral anticoagulation (OAC) has been shown to reduce the risk of ischemic stroke in patients with AF. Previous studies have demonstrated that both females and Black, Hispanic, and Asian groups are less likely to be prescribed OAC.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: William Tate, Grace Ha, Leon M. Ptaszek, Dolphurs Hayes, James M. Alzate, Joseph R. Betancourt, Jason H. Wasfy, Malissa J. Wood, Moussa Mansour Source Type: research
Po-03-061 utility of implantable loop recorders for cryptogenic strokes to detect arrhythmias other than atrial fibrillation
Implantable loop recorders (ILR) are recommended to detect atrial fibrillation (AF) in cases of cryptogenic stroke (CS). However, the utilization of loop recorders for the diagnosis of other arrhythmias in patients with a history of cryptogenic stroke is limited.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Taqi A. Rizvi, Shahkar Khan, Nnedindu Asogwa, Hai Xu, Valay K. Parikh, Philippe Akhrass, Rina R. Shah, Marcin Kowalski Source Type: research
Po-01-210 stroke risk is identified by slow blood flow and stagnant blood particles in the left atrium
Atrial fibrillation (AF) is the most common type of arrhythmia, causing irregular contraction patterns in the atrial chambers. This rhythm disorder may result in stagnant flow, leading to the formation of blood clots, especially in the left atrial appendage (LAA), and causing a thrombotic stroke. Current stroke risk assessment in AF patients is done using CHADS2 or CHA2 DS2 –VASc scores, which are based on selected clinical characteristics, without accounting for potential risk factors such as LAA thrombi formation.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Alberto Zingaro, Zan Ahmad, Carolyna Yamamoto Alves Pinto, Kensuke Sakata, Eugene G. Kholmovski, Luca Dede', Alfio Quarteroni, Natalia A. Trayanova Source Type: research
Po-04-144 impact of age on atrial arrhythmia outcomes after percutaneous asd closure
Atrial Septal Defects (ASD) are one of the most common congenital heart defects, and if unrepaired, increase the risk of atrial fibrillation (AF) and atrial flutter (AFL). AF/AFL are linked to an increased risk of stroke and heart failure yet, it is not clear from existing data whether percutaneous ASD closure reduces the overall burden of AF/AFL and whether AF/AFL prevalence is impacted by closure age.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Brendan Burke, Ghazaleh Goldar, Jeevanantham Rajeswaran, Alex Milinovich, Olivia McCloskey, Patricia Blazevic, Peter F. Aziz, Tara Karamlou, Mohamed Kanj, Patcharapong Suntharos, Joanna Ghobrial Source Type: research
Ce-452772-3 self-pulse exam for atrial fibrillation screening: a randomized controlled trial
Atrial fibrillation (AF), the most commonly treated cardiac arrhythmia, is associated with significant morbidity including the potential for stroke. Because AF is often asymptomatic, there is growing interest in AF screening. Trials of AF screening using external monitors, smartwatches, or other personal electronic devices have shown that screening increases detection of AF. Due to the cost and low yield of screening with insufficient evidence of clinical benefit, the US Preventative Services Task Force has not recommended comprehensive screening for AF at the current time.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Benjamin Chilcutt, Taylor C. Bazemore, Tiffany Armbruster, Ari Becker, Wanting Jin, Quefeng Li, Anil K. Gehi Source Type: research
Po-04-057 atrial fibrillation cured by pacemaker reprogramming
Atrial fibrillation (AF) is commonly detected by remote monitoring of implanted devices. A common question is whether to start anticoagulation in patients with detected AF at risk of stroke. However, the cause of AF is rarely able to be diagnosed or corrected. Repetitive non-reentrant ventriculoatrial synchrony (RNRVAS) is a pacemaker mediated arrhythmia that can occur in patients with intact ventriculoatrial (VA) conduction. Ventricular pacing with retrograde atrial activation that falls within the PVARP is followed by atrial pacing, often delivered while the atrium is refractory.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Erin E. Flatley, Edward P. Gerstenfeld Source Type: research
Po-01-108 elucidating the mechanism of atrial fibrillation in lamin a/c heart disease using human ipsc-derived atrial cardiomyocytes
Mutations in the LMNA gene, encoding the nuclear envelope proteins lamin A/C, cause cardiac arrhythmias, conduction disease, and dilated cardiomyopathy. Malignant arrhythmias such as atrial fibrillation (AF) and ventricular tachycardia are common and pose an increased risk of stroke and sudden cardiac death.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: William Janes, Asia Owais, Hanna Chen, Yining Chen, Michael Hill, Dawood Darbar, Srinath Yeshwant Source Type: research
Po-05-141 association of interatrial block and the development of atrial fibrillation among patients with hypertrophic cardiomyopathy
Atrial fibrillation (AF) is the most common sustained arrhythmia among those with hypertrophic cardiomyopathy (HCM), affecting 1 in 5 patients. The combination of HCM and AF is associated with an increased risk of stroke, heart failure, and mortality. Interatrial block (IAB) is a distinct electrocardiographic (ECG) pattern describing conduction delay between the right and left atria through Bachmann ’s bundle. IAB has been identified as a predictor of AF across several disease states including congestive heart failure, valvular disease, and cardiac amyloidosis.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Abdullah Alissa, Nadia Bokhari, Munther K. Homoud, Ethan Rowin, Martin S. Maron, Christopher Madias Source Type: research
Bs-452758-4 combined gene therapy approach targets parasympathetic signaling and oxidative stress to attenuate persistent atrial fibrillation development in a canine model
Atrial fibrillation (AF) is the most common arrhythmia, a major risk factor for stroke and is associated with substantial morbidity and mortality. Unfortunately, current pharmacological and interventional treatment approaches are suboptimal. Parasympathetic nervous system (PNS) activity upregulation and oxidative stress (OS), mainly generated by NADPH oxidase 2 (NOX2), have been shown as key players in AF induction and maintenance. A deeper understanding of these molecular mechanisms underlying AF and their interplay will be instrumental to the development of new, mechanism-targeted therapies for AF.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Aleksei Mikhailov, Azaria Panni, Anna Pfenniger, Shin Yoo, David Johnson, Wenwei Zhang, Markus Rottmann, William Marszalec, Asish Ghosh, Rod S. Passman, Bradley P. Knight, Rishi Arora Source Type: research
Po-701-01 nine month readmission rates and clinical outcomes of anticoagulation versus watchman device in octogenarians
Atrial Fibrillation (AF), the most common arrhythmia in older adults, is fraught with an increased risk of stroke. Studies which have demonstrated non-inferiority of Left atrial appendage occlusion (LAAO) with a watchman device compared to oral anticoagulation for stroke risk reduction in AF did not include patients greater than 80 years of age, making it difficult to generalize these results to this population.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Varun Victor, Mahmoud Khalil, Dilanthy Annappah, Ahmed Mohamed, Kirolos Barssoum Source Type: research
Ce-543-04 inter-atrial block identifies patients with low cha2ds2-vasc score but high stroke risk
Beyond current methods of risk stratification, clinical studies employing machine learning methodology have demonstrated that the 12-lead ECG harbors additional prognostic information for various cardiovascular outcomes. Interatrial block (IAB) manifests as P wave duration>120 msec and is associated with thromboembolism, atrial arrhythmias, and mortality.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Joshua Lampert, Shreyas Havaldar, David Power, Marc A. Miller, Abhishek Maan, Kartikeya Menon, Emmanuel Ekanem, Jonathan Gandhi, Daniel N. Pugliese, Daniel Ross Musikantow, Mohit K. Turagam, Valentin Fuster, Srinivas R. Dukkipati, Benjamin Glicksberg, Viv Source Type: research
Po-669-06 brain metabolism in patients with atrial fibrillation: insights from a pilot fdg-pet study
Atrial Fibrillation (AF) is an independent risk factor for incident dementia. Overt stroke, microembolism and microbleeds are among the main mechanisms linking this arrhythmia and cognitive dysfunction. Cerebral hypoperfusion related to beat-to-beat blood flow variation during AF can also explain the occurrence of dementia or mild cognitive impairment, as rhythm control strategies were shown to reduce its incidence. However, data regarding brain metabolism patterns in patients with AF are still scarce.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Gabriel Targueta, Vitor Delgado, Marcelo Melo, FRANCISCO CARLOS DA COSTA DARRIEUX Source Type: research
Po-716-02 short term readmission rates and clinical outcomes of anticoagulation versus watchman device in octogenarians
Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia with prevalence increasing with age. Left atrial appendage occlusion (LAAO) with watchman device has been found to be noninferior to oral anticoagulation for long-term stroke risk reduction in patients with AF. Patients greater than 80 years of age have been underrepresented in most of these trials making application of findings challenging in this subset of patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Varun Victor, Mahmoud Khalil, Ahmed Mohamed, Kirolos Barssoum Source Type: research
Po-661-07 a photoplethymography-based approach to atrial fibrillation-burden estimation in high-risk patients
Atrial fibrillation (AF) is the most common arrhythmia leading to hospital admission. Its incidence is linked to increased risk of stroke, congestive heart failure, and overall mortality. AF burden is a key determinant of outcomes, but accurate quantification can be limited by the cardiac monitoring period (typically days). Alternatively, longer-term monitoring comes at higher cost and often requires an invasive approach. The introduction of reliable wrist-worn devices may improve access to long-term monitoring of AF burden.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Charles A. Athill, Yuriko Tamura, Steven Szabados, Anthony Battisti, Jeffrey Ellis, Lori Crosson, Judith C. Lenane Source Type: research
Po-661-03 use of a deep learning algorithm to predict paroxysmal atrial fibrillation based on printed electrocardiographic records acquired during sinus rhythm
Atrial fibrillation (AF) is a common type of sustained arrhythmia worldwide. Asymptomatic AF, which occurs frequently, is associated with an increased incidence of ischemic stroke, heart failure, and mortality. A large number of patients with paroxysmal atrial fibrillation (PAF) remain undiagnosed due to the absence of electrocardiographic evidence of AF (AF-ECGs). If PAF could be predicted, targeted screening could improve early detection and treatment of this condition.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Yang Zhou, Yu Chen, Deyun Zhang, Shijia Geng, Guodong Wei, Ying Tian, Shenda Hong, XINGPENG LIU Source Type: research
