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Circulatory diseases – A growing global problem
International Diabetes Federation, International Society of Nephrology, World Heart Federation and World Stroke Organisation, on behalf of the Global Coalition for Circulatory Health.
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Tags: International Diabetes Federation Source Type: research

All-cause mortality and cardiovascular safety of basal insulin treatment in patients with type 2 diabetes mellitus: a systematic review with meta-analysis and trial sequential analysis
To evaluate the risk of all-cause and cardiovascular mortality, acute myocardial infarction, and stroke associated with insulin treatment in patients with type 2 diabetes.
Source: Diabetes Research and Clinical Practice - February 4, 2021 Category: Endocrinology Authors: Dimitris Varvaki Rados, Mariana Rangel Ribeiro Falcetta, Lana Catani Pinto, Cristiane Bauermann Leit ão, Jorge Luiz Gross, in memoriam Source Type: research

The association between lipoprotein (a) and carotid atherosclerosis in patients with type 2 diabetes without pre-existing cardiovascular disease: A cross-sectional study
Lipoprotein (a) [Lp(a)] consists of apolipoprotein B-100 and apolipoprotein (a) [1], which has several pathogenic roles for atherosclerosis due to the similarity to low-density lipoprotein cholesterol (LDL-C) and thrombosis due to the similarity to plasminogen [2]. As expected, the risk of cardiovascular disease (CVD) including coronary heart disease (CHD), major coronary events, myocardial infarction, stroke, and all-cause mortality was elevated in general populations with elevated Lp(a) level [3-5].
Source: Diabetes Research and Clinical Practice - December 11, 2020 Category: Endocrinology Authors: Ji Eun Jun, Hongsun Kang, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, In-Kyung Jeong Source Type: research

Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: a population-based matched cohort study
Type 2 diabetes mellitus (T2DM) is a major cause of disability and death worldwide, as it increases the risks of debilitating health conditions such as coronary heart disease (CHD) [1, 2], stroke [2], chronic kidney disease (CKD) [3] and lower extremity amputation (LEA) [4] (hereafter “unfavourable events”). These unfavourable events incur high cost of medical treatment and productivity loss [5-7]; prevention and early detection of these events among individuals with T2DM are now the focus of population health interventions.
Source: Diabetes Research and Clinical Practice - November 21, 2020 Category: Endocrinology Authors: Ka Keat Lim, Vivian Shu Yi Lee, Chuen Seng Tan, Yu Heng Kwan, Zoey Hui Xian Lim, Hwee Lin Wee, Truls Østbye, Lian Leng Low Source Type: research

Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
We prospectively investigated the incidence of stroke and its subtypes, risk factors and prognosis in Japanese patients with type 2 diabetes.
Source: Diabetes Research and Clinical Practice - October 20, 2020 Category: Endocrinology Authors: Masanori Iwase, Yuji Komorita, Toshiaki Ohkuma, Hiroki Fujii, Hitoshi Ide, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono Source Type: research

New developments in angiography for the diagnosis and management of diabetic retinopathy
The global prevalence of diabetes mellitus is expected to dramatically rise to greater to 500 million people by 2035[1] and to top 600 million by 2040[2]. Given this trend, it will be increasingly important to limit both the microvascular and macrovascular related complications of diabetes. Macrovascular, or large vessel disease, can lead to cardiovascular and stroke related complications. Microvascular changes are at the level of smaller blood vessels and can lead to renal compromise and in the eye, retinopathy.
Source: Diabetes Research and Clinical Practice - July 30, 2020 Category: Endocrinology Authors: Debarshi Mustafi, Steven S. Saraf, Qing Shang, Lisa C. Olmos de Koo Tags: Invited review Source Type: research

Stroke in the patient with diabetes (part 1) – Epidemiology, etiology, therapy and prognosis
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the...
Source: Diabetes Research and Clinical Practice - May 18, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (Part 1) - Epidemiology, etiology, therapy and prognosis
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the...
Source: Diabetes Research and Clinical Practice - May 18, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (Part 2) – Prevention and the effects of glucose lowering therapies
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. Stroke primary prevention can be achieved by controlling atrial fibrillation and hypertension, and the utilization of statins and anticoagulant therapies. Utilizing pioglitazone and GLP-1 receptor agonists reduce the risk of stroke while the utilization of metformin, α-glucosidase inhibitors, DPP-4 and SGLT-2 inhibitors have no effect.
Source: Diabetes Research and Clinical Practice - May 11, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (Part 2) -Prevention and the effects of glucose lowering therapies
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. Stroke primary prevention can be achieved by controlling atrial fibrillation and hypertension, and the utilization of statins and anticoagulant therapies. Utilizing pioglitazone and GLP-1 receptor agonists reduce the risk of stroke while the utilization of metformin, α-glucosidase inhibitors, DPP-4 and SGLT-2 inhibitors have no effect.
Source: Diabetes Research and Clinical Practice - May 11, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

A model to predict risk of stroke in middle-aged adults with type 2 diabetes generated from a nationwide population-based cohort study in Korea
This study aimed to develop a model to predict the risk of stroke in middle-aged patients with type 2 DM.
Source: Diabetes Research and Clinical Practice - April 21, 2020 Category: Endocrinology Authors: Mee Kyoung Kim, Kyungdo Han, Jae-Hyoung Cho, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee Source Type: research

Invited review. Series: Implications of the recent CVOTs in type 2 diabetes
Large cardiovascular outcome trials (CVOTs) have lent support to a cardiovascular protection with the use of SGLT2-inhibitors (SGLT2is) and GLP1-Receptor Agonists (GLP1-RAs) in subjects with type 2 diabetes. These two classes of novel glucose lowering agents have been shown to have a similar effect on the risk reduction of Major Adverse Cardiovascular Events (MACE: nonfatal myocardial infarction, nonfatal stroke, cardiovascular mortality). Nonetheless, they may not be simply interchangeable. Rather, careful evaluation of all the results of CVOTs allows identification of different effects that may allow profiling of the ide...
Source: Diabetes Research and Clinical Practice - March 16, 2020 Category: Endocrinology Authors: Angela Dardano, Roberto Miccoli, Cristina Bianchi, Giuseppe Daniele, Stefano Del Prato Source Type: research

Age-specific rate of undiagnosed diabetes and prediabetes in acute stroke
We investigated age-specific rates of undiagnosed diabetes and prediabetes among patients with acute stroke.
Source: Diabetes Research and Clinical Practice - December 8, 2019 Category: Endocrinology Authors: Paola Forti, Fabiola Maioli, Giorgia Arnone, Valeria Nativio, Marco Zoli, Maura Coveri, Giuseppe Di Pasquale, Gaetano Procaccianti Source Type: research

Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis
To examine the association of comorbid occurrence of diabetes and depression with risk of cardiovascular endpoints including cardiovascular mortality, coronary heart disease and stroke.
Source: Diabetes Research and Clinical Practice - August 13, 2019 Category: Endocrinology Authors: A. Farooqi, K. Khunti, S. Abner, C. Gillies, R. Morriss, S. Seidu Source Type: research

Secondary stroke prevention in patients with type 2 diabetes. Is time for more specific recommendations?
To the Editor:
Source: Diabetes Research and Clinical Practice - June 6, 2019 Category: Endocrinology Authors: Luis Castilla-Guerra, Mar ía del Carmen Fernandez-Moreno, Jose Antonio Perez de Leon Tags: Letter to the Editor Source Type: research

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