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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
The Coxib case: are EP receptors really guilty?
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) originate from the inhibition of cyclooxygenase (COX), which converts arachidonic acid (AA) to prostaglandin H2 (PGH2). COX consists of two isoforms, called COX-1 and COX-2. Increasing drug selectivity for COX-2 is associated with higher CV risk. Indeed, Coxibs are shown to favour a prothrombotic state, predisposing patients to myocardial infarction (MI) or thrombotic stroke, and to counter the effects of antihypertensive drugs. Indeed, Coxibs affect kidneys, by dysregulating glomerular filtration and salt/water homeostasis.
Source: Atherosclerosis - April 5, 2016 Category: Cardiology Authors: Francesca Santilli, Andrea Boccatonda, Giovanni Davì, Francesco Cipollone Tags: Review article Source Type: research
Is increased arterial stiffness a cause or consequence of atherosclerosis?
Decreased vascular compliance of the large arteries manifests as increased arterial pulse pressure with both higher systolic pressures and lower diastolic pressures without a significant change in mean pressure. The clinical consequences of higher systolic pressure include an increased risk of stroke and myocardial infarction. Our understanding of changes in vascular mechanics and its effect on blood pressure has grown as technology has improved our ability to quantify vascular stiffness in man.
Source: Atherosclerosis - April 19, 2016 Category: Cardiology Authors: Laura Hansen, W. Robert Taylor Tags: Discussion Source Type: research
Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients
Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and the proportions of different lipid species within the atherosclerotic plaque. The aim of our study was to perform a targeted lipidomic analysis of human atherosclerotic lesions, with a specific focus on PUFA-containing lipid species, to reveal differences in the fatty-acid composition of plaque in diabetic patients compared wit...
Source: Atherosclerosis - May 3, 2016 Category: Cardiology Authors: Louise Ménégaut, David Masson, Nicolas Abello, Damien Denimal, Caroline Truntzer, Patrick Ducoroy, Laurent Lagrost, Jean Paul Pais de Barros, Anne Athias, Jean Michel Petit, Laurent Martin, Eric Steinmetz, Benjamin Kretz Source Type: research
Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study
Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians. Decreased muscle mass is one of the major causes of chronic disease in adults. The purpose of this study was to analyze the relationship between muscle mass and ICAS in Korean adults.
Source: Atherosclerosis - May 3, 2016 Category: Cardiology Authors: Ho-Jung Jung, Hwanseok Jung, Taeyoung Lee, Jongho Kim, Jongsin Park, Hacsoo Kim, Junghwan Cho, Won-Young Lee, Sung-Woo Park, Eun-Jung Rhee, Hyung-Geun Oh Source Type: research
TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE−/− mice
Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development.
Source: Atherosclerosis - May 18, 2016 Category: Cardiology Authors: Siva Sankara Vara Prasad Sakamuri, Yusuke Higashi, Sergiy Sukhanov, Jalahalli M. Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar Source Type: research
Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques
Intracranial atherosclerosis is one of the main causes of ischemic stroke. However, the characteristics of intracranial arteries and atherosclerosis have rarely been studied. Therefore, we systematically investigated atherosclerotic changes in all arteries of the Circle of Willis (CoW).
Source: Atherosclerosis - May 27, 2016 Category: Cardiology Authors: Nerissa P. Denswil, Allard C. van der Wal, Katja Ritz, Onno J. de Boer, Eleonora Aronica, Dirk Troost, Mat J.A.P. Daemen Source Type: research
Serum IgE levels in coronary artery disease
The development and progression of atherosclerosis and its predisposition for unstable angina, myocardial infarction and stroke is associated with traditional risk factors such as family history, cigarette smoking, hypertension, dyslipidemia, diabetes mellitus, obesity, imbalance of the hemostatic/fibrinolytic system and sedentary lifestyle. However, much of the variability in atherosclerosis and its manifestations still remains unexplained. Nowadays, there is increasing evidence that immunologic mechanisms play a major role in etiology, prediction of coronary plaque instability and foreseeing severe reaction leading to an...
Source: Atherosclerosis - May 31, 2016 Category: Cardiology Authors: Nicholas G. Kounis, George Hahalis Source Type: research
Association between serum calcium concentration and risk of incident and fatal cardiovascular disease in the prospective AMORIS study
We examined the association of circulating calcium with incident and fatal CVD, myocardial infarction (MI), and stroke in the Swedish AMORIS cohort.
Source: Atherosclerosis - June 1, 2016 Category: Cardiology Authors: Sabine Rohrmann, Hans Garmo, Håkan Malmström, Niklas Hammar, Ingmar Jungner, Göran Walldius, Mieke Van Hemelrijck Source Type: research
Serum IgE levels in coronary artery disease
The development and progression of atherosclerosis and its predisposition for unstable angina, myocardial infarction and stroke is associated with traditional risk factors such as family history, cigarette smoking, hypertension, dyslipidemia, diabetes mellitus, obesity, imbalance of the hemostatic/fibrinolytic system and sedentary lifestyle. However, much of the variability in atherosclerosis and its manifestations still remains unexplained. Nowadays, there is increasing evidence that immunologic mechanisms play a major role in etiology, prediction of coronary plaque instability and foreseeing severe reaction leading to an...
Source: Atherosclerosis - May 31, 2016 Category: Cardiology Authors: Nicholas G. Kounis, George Hahalis Source Type: research
Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques
Intracranial atherosclerosis is one of the main causes of ischemic stroke. However, the characteristics of intracranial arteries and atherosclerosis have rarely been studied. Therefore, we systematically investigated atherosclerotic changes in all arteries of the Circle of Willis (CoW).
Source: Atherosclerosis - May 27, 2016 Category: Cardiology Authors: Nerissa P. Denswil, Allard C. van der Wal, Katja Ritz, Onno J. de Boer, Eleonora Aronica, Dirk Troost, Mat J.A.P. Daemen Source Type: research
TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE−/− mice
Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development.
Source: Atherosclerosis - May 18, 2016 Category: Cardiology Authors: Siva Sankara Vara Prasad Sakamuri, Yusuke Higashi, Sergiy Sukhanov, Jalahalli M. Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar Source Type: research
Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients
Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and the proportions of different lipid species within the atherosclerotic plaque. The aim of our study was to perform a targeted lipidomic analysis of human atherosclerotic lesions, with a specific focus on PUFA-containing lipid species, to reveal differences in the fatty-acid composition of plaque in diabetic patients compared wit...
Source: Atherosclerosis - May 3, 2016 Category: Cardiology Authors: Louise Ménégaut, David Masson, Nicolas Abello, Damien Denimal, Caroline Truntzer, Patrick Ducoroy, Laurent Lagrost, Jean Paul Pais de Barros, Anne Athias, Jean Michel Petit, Laurent Martin, Eric Steinmetz, Benjamin Kretz Source Type: research
Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study
Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians. Decreased muscle mass is one of the major causes of chronic disease in adults. The purpose of this study was to analyze the relationship between muscle mass and ICAS in Korean adults.
Source: Atherosclerosis - May 3, 2016 Category: Cardiology Authors: Ho-Jung Jung, Hwanseok Jung, Taeyoung Lee, Jongho Kim, Jongsin Park, Hacsoo Kim, Junghwan Cho, Won-Young Lee, Sung-Woo Park, Eun-Jung Rhee, Hyung-Geun Oh Source Type: research
TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE −/− mice
Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development.
Source: Atherosclerosis - May 18, 2016 Category: Cardiology Authors: Siva Sankara Vara Prasad Sakamuri, Yusuke Higashi, Sergiy Sukhanov, Jalahalli M. Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar Source Type: research
