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Source: Atherosclerosis
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Total 216 results found since Jan 2013.

Differences in the peripheral immune cell landscape in atherosclerosis – Insights from the LURIC single cell RNA-sequencing study (LURNA)
Background and Aims: Atherosclerosis and its clinical sequelae, myocardial infarction and stroke, represent the main causes of death worldwide. Although preclinical evidence has suggested the existence of a sustained inflammatory and immune response driving disease and complications, the extend of cellular alterations in human atherosclerosis remains enigmatic. Here, we employ single cell RNA-sequencing (scRNA-seq) on peripheral blood mononucleated cells in a well-defined cardiovascular risk cohort from the the LURIC trial to define changes in the immune cell landscape in atherosclerotic patients.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Horstmann, N. Anto-Michel, X. Sheng, S. Hansen, D. Westermann, W. M ärz, A. Zirlik, D. Wolf Source Type: research

Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research

Obesity and the risk of ischemic stroke in patients with atrial fibrillation: Findings from a big data analysis
Background and Aims: The use of big data analysis makes it easier to assess the contribution of individual risk factors to the prognoses, compared with large-scale epidemiological studies.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: V. Korneva, M. Druzhilov, T. Kuznetsova, D. Gavrilov, A. Gusev Source Type: research

Elevated remnant cholesterol in atherosclerotic cardiovascular disease in diabetes: A population-based prospective cohort study
Background and Aims: Elevated remnant cholesterol is causally associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of peripheral artery disease, myocardial infarction, ischemic stroke, and any ASCVD in individuals with diabetes.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: B. Wadstr öm, K. Pedersen, A. Wulff, B. Nordestgaard Source Type: research

Inflammation and dyslipidaemia as the additional risk for stroke in patients with atrial fibrillation
Background and Aims: Atrial fibrillation (AF) is often accompanied by complications, especially ischemic stroke. AF is associated with atrial structural changes that may have an inflammatory basis. Dyslipidemia is the basis for the development of atherosclerotic diseases, their role in the development of AF is not entirely clear, and previous studies suggest a "cholesterol paradox". The aim of this study is to investigate the relationship between inflammation markers and dyslipidemia risk in patients with AF and stroke
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Grigoryan, A. Stepanyan, P. Zelveian, L. Hazarapetyan Source Type: research

Small dense LDL cholesterol and ischemic stroke
Background and Aims: For decades it has been suggested that small dense low-density lipoprotein (sdLDL) may be particularly atherogenic. High levels of sdLDL are associated with an increased risk of ischemic heart disease; however, the association of sdLDL with ischemic stroke has not been explored in a large prospective study on the general population. We tested the hypothesis that high sdLDL cholesterol levels are associated with an increased risk of ischemic stroke.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Balling, B. Nordestgaard, A. Varbo, A. Langsted, P. Kamstrup, S. Afzal Source Type: research

Clinical profiles and one-year outcome in middle eastern patients with atrial fibrillation and major bleeding events. The Jordan atrial fibrillation study
Background and Aims: Oral anticoagulant agents (OACs) reduce the risk of stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) but may increase the risk of major bleeding (MB) events. There is a scarcity of studies that address the incidence, predictors, and outcomes of bleeding events in AF patients in the Middle East. This contemporary multicenter study sought to evaluate in detail the bleeding events and predictors of these events
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: A. Hammoudeh, Y. Khader, Y. Badaineh, R. Tabbalat, S. Rawashdeh, M. Jammal, S. Abrumman, I. Alhaddad Source Type: research

Lipoprotein(a), lymphocyte-monocyte ratio and progression of carotid atherosclerosis
Background and Aims: Lipoprotein(a) [Lp(a)] is an independent risk factor for carotid atherosclerosis and ischemic stroke, leading to the induction and maintenance of systemic inflammation. The ratio of different leukocyte subpopulations is the most available marker of systemic inflammation. The aim of the study was to evaluate the association of Lp(a) and lymphocyte monocyte ratio (LMR) with the progression of carotid atherosclerosis
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: O. Afanasieva, A. Tyurina, O. Pogorelova, E. Klesareva, M. Ezhov, S. Pokrovsky Source Type: research

Regulation of NC886 RNAs is associated with cardiometabolic risk factors, death and stroke
Background and Aims: Non-coding 886 is a unique polymorphically imprinted gene (Figure1). Its methylation status has been suggested to mediate DOHaD/Barker ’s hypothesis. We have previously shown that both nc886 methylation status and genetics have an independent effect on nc886 RNA levels. Here we have combined this information to predict lifelong nc886 RNA levels and study their association to cardiometabolic diseases (CMDs)
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Raji ć, S. Marttila, N. Hutri-Kähönen, M. Kähönen, T. Lehtimäki, L.-P. Lyytikäinen, P. Mishra, N. Mononen, O. Raitakari, M. Waldenberger, T. Delerue, W. März, M. Kleber, E. Harville, R. Zhang, E. Raitoharju Source Type: research

Loss of function and missense variants in CCR2 and protection against atherosclerotic disease
Background and Aims: MCP-1 governs monocyte recruitment to atherosclerotic lesions. Coherent evidence from genetic analyses and large-scale epidemiological studies supports an association between circulating MCP-1 levels and risk of coronary artery disease and atherosclerotic stroke. Still, it remains unknown if pharmacologically targeting CCR2, the cognate receptor of MCP1, would offer protection against cardiovascular disease.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Georgakis, R. Malik, M. Dichgans Source Type: research

BMP-7 attenuates TLR4-NLRP3 inflammasome mediated pyroptosis in vascular smooth muscle cells in atherosclerotic plaques
Background and Aims: Atherosclerosis (ATH) is an inflammation-mediated disease in which cell death underlies the formation of lesions along the intima layer of vascular walls resulting in vessel narrowing, decreased blood-flow, and increased risk of lesion rupture leading to myocardial infarction and stroke. The current study was undertaken to investigate whether inflammation in ATH can induce pyroptosis in vascular smooth muscle cells (vSMC ’s). To study this, we established disturbed flow-induced hemodynamic injury to the vascular wall using our partial left carotid artery ligation (PLCA) model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: D. Singla, C. Narasimhulu Source Type: research

Triglyceride-lowering therapy for the prevention of cardiovascular events, stroke, and mortality in patients with diabetes: A meta-analysis of randomized controlled trials
Triglyceride (TG)-lowering therapy is efficient for the prevention of cardiovascular disease (CVD) in the general population; however, for diabetic individuals, it is more controversial. The purpose of this study was to pool the results from randomized controlled trials (RCTs) to clarify whether the lowering of TG is beneficial for the prevention of CVD events, stroke, and mortality in subjects with diabetes.
Source: Atherosclerosis - July 12, 2023 Category: Cardiology Authors: Xiu Hong Yang, Qian Ming Tu, Li Li, Yong Ping Guo, Nian Song Wang, Hui Min Jin Source Type: research

Sex differences in the association between stroke risk factors and pre-clinical predictors of stroke in the childhood determinants of Adult Health study
We examined these associations with carotid artery structure and function in a prospective cohort study.
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Mohammad Shah, Marie-Jeanne Buscot, Jing Tian, Hoang T. Phan, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall Source Type: research

Plasma TSH and cardiovascular disease in the general population: A mendelian randomization study of 105,224 individuals
The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - May 23, 2023 Category: Cardiology Authors: Nawar Dalila, Ruth Frikke-Schmidt, B ørge G. Nordestgaard, Anne Tybjærg-Hansen Source Type: research

Effectiveness of Internet-based health management in patients with dyslipidemia: A four-year longitudinal study
This study was conducted to provide health guidance and education to people with dyslipidemia using an Internet health management platform and to assess the effectiveness of Internet health management and intervention in improving health-related behaviors and controlling blood lipids.
Source: Atherosclerosis - May 7, 2023 Category: Cardiology Authors: Yuqi Dou, Botian Chen, Xue Yu, Defu Ma Source Type: research