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Plasma TSH and cardiovascular risk in the general population
Background and Aims: The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Dalila, R. Frikke-Schmidt, B. Nordestgaard, A. Tybjaerg-Hansen Source Type: research

Plasma TSH and cardiovascular disease in the general population: A mendelian randomization study of 105,224 individuals
The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - May 23, 2023 Category: Cardiology Authors: Nawar Dalila, Ruth Frikke-Schmidt, B ørge G. Nordestgaard, Anne Tybjærg-Hansen Source Type: research

Lipoprotein(a) and cardiovascular disease: Make use of the knowledge we have
There is strong evidence that Lp(a) is a causal risk factor for cardiovascular disease [1]. This includes outcomes such as coronary artery disease, aortic valve stenosis, ischemic stroke, peripheral arterial disease, cardiovascular mortality and heart failure as recently reviewed by Arsenault and Kamstrup [2]. The most recent European Atherosclerosis Society Lp(a) Consensus Statement provides data from the UK Biobank which clearly demonstrates that there is a continuous relationship between increasing Lp(a) concentrations and increasing risk for these outcomes [1] (see Fig.
Source: Atherosclerosis - November 22, 2022 Category: Cardiology Authors: Florian Kronenberg Tags: Editorial Source Type: research

Lifetime risk predictions for cardiovascular diseases: competing risks analyses on a population-based cohort in Sweden
There are guideline discussions on a lifetime approach to cardiovascular risk. Many of the available risk models estimate the short-term, usually 10-year risk of non-fatal and fatal cardiovascular diseases (CVD) grouped together. We aimed to develop lifetime risk models for non-fatal coronary heart disease, stroke, heart failure and death from CVD and non-CVD.
Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Anna Stenling, Christel H äggström, Margareta Norberg, Fredrik Norström Source Type: research

Cardiovascular Incomes In The Hypertensive And Diabetic Mediterranean Population Older Than 65 Years Old
Background and Aims: In Spain, hypertension and DM are major health problems. The importance of determining the CV risk associated with both is based on the evidence of simultaneous CV risk factors potentiate each other, giving rise to a total CV risk that is greater than the sum of its components. Our objective was to study the income from coronary heart disease, heart failure or stroke produced in these patients during follow-up.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: B. Roig-Espert, J.J. Tamarit-Garc ía, A. González-Cruz-Cervellera, V. Pallarés-Carratalá, P. Morillas-Blasco Tags: Posters 26 - 29 May, 2019 Source Type: research

Homoarginine Supplementation Ameliorates Atherosclerosis
Background and Aims: Homoarginine (HA) is an emerging biomarker with low levels associated with increased risk of cardiovascular disease (CVD) in epidemiological studies. Recently, we identified HA supplementation to be beneficial in murine models of ischemic stroke and chronic heart failure. However, the underlying mechanism remains elusive. As both CV entities share atherosclerosis as an underlying pathology, we hypothesize that HA supplementation may protect against atherosclerosis.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: K. Nitz, C. Preischl, M. Lacy, C. B ürger, S. Reim, C. Weber, E. Lutgens, D. Atzler Tags: E-poster session Source Type: research

Coronary artery calcium score to guide hypertension therapy!
Hypertension is the most prevalent non-communicable disease, estimated to affect 1.13 billion individuals nowadays. It is the leading preventable cause of mortality worldwide and a major risk factor for coronary artery disease, heart failure, stroke and chronic renal diseases in developed and developing countries.1,2. Worldwide, the aging population, decreased fitness and obesity epidemic have contributed to the increased prevalence of hypertension3. Given that, it poses a significant health and economic challenge to both developed and developing countries.
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Ahmed Aljizeeri, Ahmed Alsaileek, Mouaz H. Al-Mallah Tags: Editorial Source Type: research

Activation of protease-activated receptors in patients with new onset of atrial fibrillation contributes to systemic atherosclerotic risk
Aim: Atrial fibrillation (AF) remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world. A complex array of pathophysiological changes including fibrosis and inflammation increasing the propensity of the atria to develop or maintain AF. At the same time, these alterations are involved in the occurrence of the systemic hypercoagulable state in which protease-activated receptors (PARs) 1 and 2 are discussed to be mediators. We wanted to evaluate the pathomechanistic link between inflammation, hypercoagulability and the atherosclerotic risk in the context of PAR1 and PAR2 activation.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Julian Friebel, Marco Witkowski, Termeh Tabaraie, Max Wegner, Evelyn R üdiger, Daniel Steffens, Oskar Galuszka, Mario Kasner, Ulf Landmesser, Ursula Rauch-Kröhnert Source Type: research

Frontal plane T-wave axis orientation predicts coronary events: Findings from the Moli-sani study
The orientation of the frontal plane T-wave axis (T axis) is a reliable measure of ventricular repolarisation. We investigated the association between T-axis and the risk of coronary heart disease (CHD), heart failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality.
Source: Atherosclerosis - July 22, 2017 Category: Cardiology Authors: Licia Iacoviello, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Livia Rago, Amalia De Curtis, Deodato Assanelli, Fabio Badilini, Martino Vaglio, Mariarosaria Persichillo, Peter W. Macfarlane, Chiara Cerletti, Maria Benedetta Donati, Giovan Source Type: research

The association of lipoprotein(a) with incident heart failure hospitalization: Atherosclerosis Risk in Communities Study
We examined the association of Lp(a) levels with incident HF hospitalization in the Atherosclerosis Risk in Communities (ARIC) study. We also assessed the relationship between Lp(a) levels and arterial stiffness as a potential mechanism for development of HF.
Source: Atherosclerosis - May 12, 2017 Category: Cardiology Authors: Anandita Agarwala, Yashashwi Pokharel, Anum Saeed, Wensheng Sun, Salim S. Virani, Vijay Nambi, Chiadi Ndumele, Eyal Shahar, Gerardo Heiss, Eric Boerwinkle, Suma Konety, Ron C. Hoogeveen, Christie M. Ballantyne Source Type: research

Oral health and cardiovascular disease risk in a cohort of periodontitis patients
The aim of this study was to determine whether oral health is uniformly associated with three different cardiovascular diseases (CVDs), including myocardial infarction (MI), stroke, and heart failure (HF), which has not been studied previously.
Source: Atherosclerosis - May 11, 2017 Category: Cardiology Authors: Anders Holmlund, Erik Lampa, Lars Lind Source Type: research

Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS
Aliskiren previously was found to have potentially harmful effects in diabetic individuals prescribed concomitant angiotensin converting enzyme inhibitors (ACEI) or angiotenisn receptor antagonists (ARB). We explored potential effects of aliskiren on coronary atheroma progression and major adverse cardiovascular events (MACE: death/non-fatal MI/non-fatal stroke/hospitalization for heart failure/hospitalization for ACS/arterial revascularization) in patients with and without diabetes mellitus (DM).
Source: Atherosclerosis - October 21, 2015 Category: Cardiology Authors: Rishi Puri, Steven E. Nissen, Venu Menon, Mingyuan Shao, Amy Hsu, George L. Bakris, John J.P. Kastelein, Bryan Williams, Juergen Armbrecht, Patrick Brunel, Yu Kataoka, Stephen J. Nicholls Source Type: research

A Mediterranean diet and risk of myocardial infarction, heart failure and stroke: a population-based cohort study
The Mediterranean diet, which is palatable and easily achievable, has been associated with lower all-cause and cardiovascular disease (CVD) incidence and mortality. Data on heart failure (HF) and stroke types are lacking. The aim was to examine a Mediterranean diet in relation to incidence of myocardial infarction (MI), HF and stroke types in a Swedish prospective cohort.
Source: Atherosclerosis - September 2, 2015 Category: Cardiology Authors: Thanasis G. Tektonidis, Agneta Åkesson, Bruna Gigante, Alicja Wolk, Susanna C. Larsson Source Type: research

Carotid intima-media thickness is associated with incidence of hospitalized atrial fibrillation
Conclusion: Carotid IMT was independently associated with incidence of hospitalized AF in this study of middle-aged subjects from the general population. The results suggest that arterial thickening can predict future AF.Highlights:
Source: Atherosclerosis - March 20, 2014 Category: Cardiology Authors: Samuel Adamsson Eryd, Gerd Östling, Maria Rosvall, Margaretha Persson, J. Gustav Smith, Olle Melander, Bo Hedblad, Gunnar Engström Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research

The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trial
Abstract: Background: Current guidelines recommend intensive low-density lipoprotein (LDL) cholesterol lowering with statins, with a target of 70mg/dL (1.81mmol/L) LDL cholesterol for those with a very high risk of coronary artery events. However, there is no multicenter study assessing the effect of intensive lipid-lowering therapy with statins on acute coronary syndrome (ACS) in a Chinese population with low baseline LDL cholesterol levels.Methods and results: Patients (n=1355) with ACS were treated with a moderate dose of statin (atorvastatin 10 mg/d, or equivalent dose of other statins, n=675) or with an intensive dose...
Source: Atherosclerosis - March 20, 2014 Category: Cardiology Authors: Shui-ping Zhao, Bi-lian Yu, Dao-quan Peng, Yong Huo Tags: Clinical & Population Research – Intervention Source Type: research

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