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Source: Atherosclerosis
Condition: Heart Attack
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Total 99 results found since Jan 2013.
Therapeutic targeting of the LncRNA IMSET suppresses inflammation and atherosclerotic plaque progression
Background and Aims: Perpetual monocyte/macrophage recruitment and subsequent foam cell formation characterises advanced atherosclerotic plaques, especially lesions precipitating myocardial infarction and stroke. Recent advances have illuminated macrophage diversity within atherosclerotic plaques, with select populations attributed a deleterious role. Accordingly, novel targets within specific macrophage subsets may yield therapeutic potential.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: K. Di Gregoli, A. Bond, S. Smith, S. George, J. Johnson Source Type: research
Differences in the peripheral immune cell landscape in atherosclerosis – Insights from the LURIC single cell RNA-sequencing study (LURNA)
Background and Aims: Atherosclerosis and its clinical sequelae, myocardial infarction and stroke, represent the main causes of death worldwide. Although preclinical evidence has suggested the existence of a sustained inflammatory and immune response driving disease and complications, the extend of cellular alterations in human atherosclerosis remains enigmatic. Here, we employ single cell RNA-sequencing (scRNA-seq) on peripheral blood mononucleated cells in a well-defined cardiovascular risk cohort from the the LURIC trial to define changes in the immune cell landscape in atherosclerotic patients.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Horstmann, N. Anto-Michel, X. Sheng, S. Hansen, D. Westermann, W. M ärz, A. Zirlik, D. Wolf Source Type: research
Plasma TSH and cardiovascular risk in the general population
Background and Aims: The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Dalila, R. Frikke-Schmidt, B. Nordestgaard, A. Tybjaerg-Hansen Source Type: research
Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research
Elevated remnant cholesterol in atherosclerotic cardiovascular disease in diabetes: A population-based prospective cohort study
Background and Aims: Elevated remnant cholesterol is causally associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of peripheral artery disease, myocardial infarction, ischemic stroke, and any ASCVD in individuals with diabetes.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: B. Wadstr öm, K. Pedersen, A. Wulff, B. Nordestgaard Source Type: research
BMP-7 attenuates TLR4-NLRP3 inflammasome mediated pyroptosis in vascular smooth muscle cells in atherosclerotic plaques
Background and Aims: Atherosclerosis (ATH) is an inflammation-mediated disease in which cell death underlies the formation of lesions along the intima layer of vascular walls resulting in vessel narrowing, decreased blood-flow, and increased risk of lesion rupture leading to myocardial infarction and stroke. The current study was undertaken to investigate whether inflammation in ATH can induce pyroptosis in vascular smooth muscle cells (vSMC ’s). To study this, we established disturbed flow-induced hemodynamic injury to the vascular wall using our partial left carotid artery ligation (PLCA) model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: D. Singla, C. Narasimhulu Source Type: research
The attenuated metabolic suppression and elevated mTOR levels in replicatively aged fibroblasts may contribute to atherosclerosis in Hutchinson Gilford Progeria
Background and Aims: Hutchinson Gilford Progeria (HGP) is characterized by accelerated aging and premature death caused by myocardial infarction or stroke. Enhanced metabolism and proliferation may accelerate senescence entry and atherogenesis. We therefore related cellular proliferation and exogenous stress to mTOR signaling in four control and four HGP fibroblast cell lines.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: J. Mensch, K. J äger, M. Grimmig, A. Hartmann, M. Walter Source Type: research
Plasma TSH and cardiovascular disease in the general population: A mendelian randomization study of 105,224 individuals
The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - May 23, 2023 Category: Cardiology Authors: Nawar Dalila, Ruth Frikke-Schmidt, B ørge G. Nordestgaard, Anne Tybjærg-Hansen Source Type: research
Artificial intelligence for high-risk plaque detection on carotid CT angiography
Atherothrombotic events such as myocardial infarction and stroke most commonly arise from the disruption of plaques that pathologically exhibit a large lipid-rich core, thin fibrous cap, and outward remodeling [1,2]. These high-risk morphological ‘vulnerable plaque’ features can be identified early by invasive and non-invasive imaging modalities [3], and their presence portends an increased lesion-specific and patient-level risk of future cardiovascular events [4–7]. In this issue of Atherosclerosis, Buckler et al.
Source: Atherosclerosis - January 14, 2023 Category: Cardiology Authors: Andrew Lin Tags: Editorial Source Type: research
Lipoprotein(a) variability over time in adult lipid clinic patients
Lipoprotein(a) (Lp[a]) is a low-density lipoprotein (LDL)-like particle in which apolipoprotein (apo) B is covalently bound to a plasminogen-like molecule called apo(a) [1]. Elevated plasma Lp(a) concentration is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, stroke and cardiac death [1]. The European Atherosclerosis Society, European Society of Cardiology and Canadian Cardiovascular Society (CCS) dyslipidemia guidelines recommend measurement of Lp(a) once in an individual's lifetime to identify patients with high levels who would benefit from earlier, more i...
Source: Atherosclerosis - September 5, 2022 Category: Cardiology Authors: Isabel Shamsudeen, Robert A. Hegele Tags: Correspondence Source Type: research
Frequent drinking is more predictive of ischemic stroke than binge drinking, but not of myocardial infarction
Alcohol consumption has complex effects on myocardial infarction (MI) and ischemic stroke. We investigated the difference in associations according to drinking patterns (drinking frequency vs. amount per occasion) and sex.
Source: Atherosclerosis - April 24, 2022 Category: Cardiology Authors: In Young Cho, Jung Eun Yoo, Kyungdo Han, Dahye Kim, Su-Min Jeong, Sungeun Hwang, Heesun Lee, Keun Hye Jeon, Dong Wook Shin Source Type: research
Generation of cardio-protective antibodies after pneumococcal polysaccharide vaccine: Early results from a randomised controlled trial
Observational studies have demonstrated that the pneumococcal polysaccharide vaccine (PPV) is associated with reduced risk of cardiovascular events. This may be mediated through IgM antibodies to OxLDL, which have previously been associated with cardioprotective effects. The Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE) is a double-blind, randomised controlled trial (RCT) of PPV in preventing ischaemic events. Participants received PPV or placebo once at baseline and are being followed-up for incident fatal and non-fatal myocardial infarction or stroke over 6 years.
Source: Atherosclerosis - March 5, 2022 Category: Cardiology Authors: Shu Ren, Philip M. Hansbro, Wichat Srikusalanukul, Jay C. Horvat, Tegan Hunter, Alexandra C. Brown, Roseanne Peel, Jack Faulkner, Tiffany-Jane Evans, Shu Chuen Li, David Newby, Alexis Hure, Walter P. Abhayaratna, Sotirios Tsimikas, Ayelet Gonen, Joseph L. Source Type: research
Novel insights into lipoprotein(a): News from Atherosclerosis
Lipoprotein(a) [Lp(a)] has had a varied history. While numerous epidemiologic studies documented an association of elevated Lp(a) levels with increased risk of cardiovascular disease [1], it was not until the advent of genetic studies, especially those using a Mendelian randomization design, that the association with cardiovascular outcomes, including myocardial infarction (MI) and ischaemic stroke, as well as aortic valve stenosis, was demonstrated [2 –10]. Collectively, these findings prompted expert reappraisal and reconsideration of Lp(a) in clinical guidelines [11–13] and catalysed the development of novel therape...
Source: Atherosclerosis - February 7, 2022 Category: Cardiology Authors: Jane Stock Source Type: research
The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events
Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke.Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of rupt...
Source: Atherosclerosis - December 22, 2020 Category: Cardiology Authors: Dani ëlle M. Coenen, Alexandra C.A. Heinzmann, Mieke F.A. Karel, Judith M.E.M. Cosemans, Rory R. Koenen Tags: Review article Source Type: research
Leukotriene receptor antagonists role in recuding the cardiovascular and cerebrovascular risk: A case-control study in southern Spain
Background and Aims: Leukotriene receptor antagonists (LTRAs) are used in asthmatic patients, however different studies indicate that LTRAs can decrease intimal hyperplasia after vascular injury, and have a protective role in cerebral ischemia. The aim of our study was to assess the role of LTRAs in reducing myocardial infarction (MI) and ischemic stroke (IS) risk in patients from two Primary Health Care Centers of Granada.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: M. Hoxha, V. Malaj, C. Rivilla Doce, A.B. Cavanillas Source Type: research
