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A comparative study of different doses of bone marrow-derived mesenchymal stem cells improve post-stroke neurological outcomes via intravenous transplantation
CONCLUSIONS: Treatment with MSC restored the sensory and motor function of cerebral ischemia rats, indicating it may be an effective therapy for ischemic stroke.PMID:36379315 | DOI:10.1016/j.brainres.2022.148161
Source: Brain Research - November 15, 2022 Category: Neurology Authors: Yuan Chen Dingguo Peng Jingyi Li Lingling Zhang Jiacheng Chen Lin Wang Yansong Gao Source Type: research

Clinical neurorestorative cell therapies for stroke
Prog Brain Res. 2021;265:231-247. doi: 10.1016/bs.pbr.2021.06.006. Epub 2021 Aug 13.ABSTRACTClinical neurorestorative cell therapies for stroke have been explored for over 20 years. Majority cell therapies have shown neurorestorative effects for stroke on non-double-blind studies. In this review, we summarize types of cell transplantation, transplanted routes, therapeutic time windows, dosage, results of exploring trials or clinical studies, results of multicenter, double-blind or observing-blind, randomized, placebo-controlled clinical trials. The clinical application prospects of majority cell therapies for stroke need t...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Hongyun Huang Gengsheng Mao Lin Chen Hari Shanker Sharma Source Type: research

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

Injectable biomaterial shuttles for cell therapy in stroke
Brain Res Bull. 2021 Aug 12:S0361-9230(21)00242-2. doi: 10.1016/j.brainresbull.2021.08.002. Online ahead of print.ABSTRACTIschemic stroke (IS) is the leading cause of disability and contributes to a significant socio-economic cost in the western world. Brain repair strategies investigated in the pre-clinical models include the delivery of drug or cell-based therapeutics; which is hindered by the complex anatomy and functional organization of the brain. Biomaterials can be instrumental in alleviating some of these challenges by providing a structural support, localization, immunomodulation and/or modulating cellular cross-t...
Source: Brain Research - August 15, 2021 Category: Neurology Authors: Juhi Samal Tatiana Segura Source Type: research

iTRAQ-based proteomic analysis after mesenchymal stem cell line transplantation for ischemic stroke.
Abstract Transplantation with mesenchymal stem cells (MSCs) has been reported to promote functional recovery in animal models of ischemic stroke. However, the molecular mechanisms underlying the therapeutic effects of MSC transplantation have been only partially elucidated. The purpose of this study was to comprehensively identify changes in brain proteins in rats treated with MSCs for ischemic stroke, and to explore the multi-target mechanisms of MSCs using a proteomics-based strategy. Twenty-eight proteins were found to be differentially expressed following B10 MSC transplantation in adult male Wistar rats, as a...
Source: Brain Research - May 19, 2020 Category: Neurology Authors: Mitaki S, Nagai A, Wada Y, Onoda K, Md Sheikh A, Adachi E, Matsumoto KI, Yamaguchi S Tags: Brain Res Source Type: research

Hypoxia conditioning enhances neuroprotective effects of aged human bone marrow mesenchymal stem cell-derived conditioned medium against cerebral ischemia in vitro.
Abstract Therapeutic transplantation of autologous bone marrow mesenchymal stem cells (BMSCs) holds great promise for ischemic stroke, yet the efficacy is negatively impacted by aging. Here, we examined whether hypoxia conditioning could enhance aged human BMSCs-induced neuroprotection via secretome action. Primary cultured mouse neurons were exposed to oxygen glucose deprivation (OGD) to mimic ischemic stroke in vitro, then randomized into a hypoxia conditioned aged human BMSCs-conditioned medium (BMSC-hypoCM) versus normoxia conditioned (BMSC-norCM). After 22 hours of reperfusion, cell viability was significantl...
Source: Brain Research - September 2, 2019 Category: Neurology Authors: Zhang Y, Ma L, Su Y, Su L, Lan X, Wu D, Han S, Li J, Kvederis L, Corey S, Borlongan CV, Ji X Tags: Brain Res Source Type: research

Efficacy of Stem Cell-Based Therapies for Stroke.
Abstract Stroke remains a prevalent disease with limited treatment options. Available treatments offer little in the way of enhancing neurogenesis and recovery. Because of the limitations of available treatments, new therapies for stroke are needed. Stem cell-based therapies for stroke offer promise because of their potential to provide neurorestorative benefits. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons in order to improve neurological recovery. The mechanism through which stem cell treatments mediate their therapeutic effect is largely depe...
Source: Brain Research - August 1, 2019 Category: Neurology Authors: Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC Tags: Brain Res Source Type: research

Bioluminescence imaging of transplanted human endothelial colony-forming cells in an ischemic mouse model.
The objectives of this study are to visualize the fate of infused human cord blood derived ECFCs via bioluminescence imaging (BLI) in an ischemic stroke mouse model and to determine the therapeutic effects of ECFC transplantation. ECFCs derived from human umbilical cord blood were infected with lentivirus carrying enhanced green fluorescent protein (eGFP) and firefly luciferase (Luc2) double fusion reporter gene. Labeled ECFCs were grafted into a photothrombotic ischemic stroke mouse model via intra-arterial injection though the left cardiac ventricle. The homing of infused cells and functional recovery of stroke mice were...
Source: Brain Research - March 29, 2016 Category: Neurology Authors: Ding J, Zhao Z, Wang C, Wang CX, Li PC, Qian C, Teng GJ Tags: Brain Res Source Type: research

Intranasal administration of Human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke.
In this study, we investigated whether intranasal administration of human umbilical cord mesenchymal stem cells (hUCMSCs)-CM has the therapeutic effects in rats after stroke. Adult male rats were subjected to middle cerebral artery occlusion (MCAo) and were treated by intranasal routine with or without hUCMSCs-CM (1ml/kg/d), starting 24h after MCAo and daily for 14 days. Neurological functional tests, blood brain barrier (BBB) leakage were measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry, and Western blot, respectively. hUCMSCs-CM treatment of stroke by intranasal routine starti...
Source: Brain Research - August 13, 2015 Category: Neurology Authors: Zhao Q, Hu J, Xiang J, Gu Y, Jin P, Hua F, Zhang Z, Liu Y, Zan K, Zhang Z, Zu J, Yang X, Shi H, Zhu J, Xu Y, Cui G, Ye X Tags: Brain Res Source Type: research

Regenerative cellular Therapies for neurologic Diseases.
Abstract The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which ...
Source: Brain Research - July 31, 2015 Category: Neurology Authors: Levy M, Boulis N, Rao M, Svendsen CN Tags: Brain Res Source Type: research

Stem cell-paved biobridges facilitate stem transplant and Host brain cell Interactions for stroke therapy.
Abstract Distinguished by an infarct core encased within a penumbra, stroke remains a primary source of mortality within the United States. While our scientific knowledge regarding the pathology of stroke continues to improve, clinical treatment options for patients suffering from stroke are extremely limited. Tissue plasminogen activator (tPA) remains the sole FDA-approved drug proven to be helpful following stroke. However, due to the need to administer the drug within 4.5h of stroke onset its usefulness is constrained to less than 5% of all patients suffering from ischemic stroke. One experimental therapy for t...
Source: Brain Research - March 11, 2015 Category: Neurology Authors: Duncan K, Gonzales-Portillo GS, Acosta S, Kaneko Y, Borlongan CV, Tajiri N Tags: Brain Res Source Type: research