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An Inhibitory and Beneficial Effect of Chlorpromazine and Promethazine (C+P) on Hyperglycolysis through HIF-1 α Regulation in Ischemic Stroke
CONCLUSION: C+P, partially depending on hypothermia, attenuates hyperglycolysis and NOX activation through HIF-1α regulation.PMID:33811844 | DOI:10.1016/j.brainres.2021.147463
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Sichao Guo Eric Cosky Fengwu Li Longfei Guan Yu Ji Wenjing Wei Changya Peng Xiaokun Geng Yuchuan Ding Source Type: research

Selective-cerebral-hypothermia-induced neuroprotection against-focal cerebral ischemia/reperfusion injury is associated with an increase in SUMO2/3 conjugation.
In this study, we investigated the effect of selective cerebral hypothermia on SUMO2/3 conjugation during focal cerebral I/R injury. A total of 140 Sprague-Dawley rats were divided into four groups. In the sham group, only the carotid artery was exposed. The endoluminal filament technique was used to induce middle cerebral artery occlusion in the other three groups. After 2 hours of occlusion, the filaments were slowly removed to allow blood reperfusion in the I/R group. In the hypothermia (HT) group and normothermia (NT) group, normal saline at 4°C and 37°C, respectively , was perfused through the carotid artery, follow...
Source: Brain Research - February 1, 2021 Category: Neurology Authors: Sun G, Qin W, Wang Q, Sun X, Chen H, Li J, Sun L, Shi F, Zhang G, Wang M Tags: Brain Res Source Type: research

Neuroprotection by Mesenchymal Stem Cell (MSC) Administration is Enhanced by Local Cooling Infusion (LCI) in Ischemia.
CONCLUSION: Therapeutic hypothermia upregulated Miro1 and enhanced MSC mitochondrial transfer-mediated neuroprotection in ischemic stroke. Combination of LCI with MSC therapy may facilitate clinical translation of this approach. PMID: 31454517 [PubMed - as supplied by publisher]
Source: Brain Research - August 23, 2019 Category: Neurology Authors: Wei W, Wu D, Duan Y, Elkin KB, Chandra A, Guan L, Peng C, He X, Wu C, Ji X, Ding Y Tags: Brain Res Source Type: research

Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation.
Abstract Stroke poses a serious health and economic burden, and the lack of treatment options necessitates a viable therapy. Hypothermia represents a promising stroke therapy, yet side effects of full-body cooling, such as pneumonia, limit its clinical application. Selective endovascular cooling (SEC), via infusion of cold saline through the intraarterial artery, represents an attractive alternative by locally cooling the brain while preserving body temperature. However, the mechanisms underlying SEC are poorly understood. Brain-derived neurotrophic factor (BDNF) is a widely recognized promotor of neuroplasticity ...
Source: Brain Research - August 11, 2019 Category: Neurology Authors: Corey S, Abraham DI, Kaneko Y, Lee JY, Borlongan CV Tags: Brain Res Source Type: research

Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat.
CONCLUSIONS: The combination approach enhanced the efficacy of hypothermia-induced neuroprotection following ischemic stroke. Our findings provide a hint to translate the combination method from bench to bedside. PMID: 30584925 [PubMed - as supplied by publisher]
Source: Brain Research - December 22, 2018 Category: Neurology Authors: Wu D, Zhi X, Duan Y, Zhang M, An H, Wei W, Dong K, Zhang Y, Shi J, He X, Zhang J, Wu C, Meng R, Ding Y, Ji X Tags: Brain Res Source Type: research

Levetiracetam-mediated improvement of decreased NMDA-induced glutamate release from nerve terminals during hypothermia.
Abstract A combination of a beneficial neuroprotectant, hypothermia, with targeted medication is a perspective therapeutic approach. Here, we analyzed both non-specific (deep and profound hypothermia, 27 °C and 17 °C, respectively) and targeted (anticonvulsant drug levetiracetam) modulation of l-[14C]glutamate release induced by activation of presynaptic NMDA, AMPA, and kainate receptors in rat brain nerve terminals (synaptosomes). Gradual dynamics of hypothermia-mediated decrease in synaptosomal l-[14C]glutamate release evoked by the receptor agonists NMDA-, AMPA-, and kainate (250 μM) has been demonstra...
Source: Brain Research - October 24, 2018 Category: Neurology Authors: Pastukhov A, Borisova T Tags: Brain Res Source Type: research

Dihydrocapsaicin (DHC) Enhances the Hypothermia-Induced Neuroprotection Following Ischemic Stroke Via PI3K/Akt Regulation In Rat.
CONCLUSIONS: The combination approach is able to enhance the efficiency of hypothermia and efficacy of hypothermia-induced neuroprotection following ischemic stroke. The findings here move us a step closer towards translating this long recognized TH from bench to bedside. PMID: 28684048 [PubMed - as supplied by publisher]
Source: Brain Research - July 3, 2017 Category: Neurology Authors: Wu D, Shi J, Elmadhoun O, Duan Y, An H, Zhang J, He X, Meng R, Liu X, Ji X, Ding Y Tags: Brain Res Source Type: research

Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion.
In conclusion, we demonstrated the neuroprotective effects of transarterial regional hypothermia in an ischemic model of pMCAO with tCHP. Even though MCAO is persistent, cold infusion via the ICA is neuroprotective for the penumbra, suggesting the wider therapeutic application of this therapy. PMID: 27663968 [PubMed - as supplied by publisher]
Source: Brain Research - September 19, 2016 Category: Neurology Authors: Kurisu K, Abumiya T, Ito M, Gekka M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Houkin K Tags: Brain Res Source Type: research

Therapeutic effect of tPA in ischemic stroke is enhanced by its combination with normobaric oxygen and hypothermia or ethanol.
CONCLUSIONS: Neuroprotection after stroke can be enhanced by combination treatment with either EtOH or hypothermia in the presence of t-PA and 60% NBO. Because the effects produced by EtOH and hypothermia are comparable, their mechanism of action may be not only similar but also could be interchangeable in future clinical trials. PMID: 26319679 [PubMed - as supplied by publisher]
Source: Brain Research - August 28, 2015 Category: Neurology Authors: Ji Z, Liu K, Cai L, Peng C, Xin R, Gao Z, Zhao E, Rastogi R, Han W, Rafols JA, Geng X, Ding Y Tags: Brain Res Source Type: research