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Source: The American Journal of Medicine
Condition: Heart Attack
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Total 44 results found since Jan 2013.
Inflammatory bowel disease and cardiovascular diseases
Inflammatory Bowel Disease is comprised of two major subtypes: Crohn's disease and ulcerative colitis, characterized by chronic inflammation of the gastrointestinal tract with extraintestinal manifestations that can involve a number of systems.1 There were estimated to be 7 million cases of inflammatory bowel disease globally in 2017, and at the national level, the United States had the highest age-standardized prevalence rate (464.5 per 100,000 population) of inflammatory bowel disease.2 Atherosclerotic cardiovascular diseases is defined as a history of acute coronary syndrome, myocardial infarction, stable or unstable an...
Source: The American Journal of Medicine - September 1, 2022 Category: General Medicine Authors: Bing Chen, Lauren V Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Edward V. Loftus, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J Lavie, Chayakrit Krittanawong Tags: Clinical Research Study Source Type: research
Impact of Bleeding on Myocardial Infarction, Stroke, and Death During 12 Months Dual Antiplatelet Therapy After Acute Coronary Syndrome
Bleeding remains a complication during dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS). Some data suggest a link between bleeding and worsened vascular outcomes. However, this association is unclear, due to omitting of minor bleedings when applying conservative scales. In contrast, the Platelet Inhibition and Outcomes (PLATO) trial classification used broad realistic capturing of all bleedings.
Source: The American Journal of Medicine - August 14, 2022 Category: General Medicine Authors: Victor L. Serebruany, Jean-Fran çois Tanguay, Wiktor Kuliczkowski, Eric Heidel, Moo Hyun Kim, Dan Atar Tags: Clinical Research Study Source Type: research
Impact of Bleeding on Myocardial Infarction, Stroke and Death During 12-months Dual Antiplatelet Therapy After Acute Coronary Syndrome
One of the largest controversies of modern antithrombotic strategies is the uncertain relation among the potency and duration of dual antiplatelet therapy (DAPT) with associated bleeding rates1-3, and whether or not bleeding impacts mortality, myocardial infarction (MI) and stroke risks4-6. Some data from clinical trials1-5 and registries7,8 suggest that such a link is valid, however, this association is not established partly due to capturing of exclusively major or/and catastrophic events while omitting minor and minimal episodes, and applying restrictive bleeding scales9.
Source: The American Journal of Medicine - August 14, 2022 Category: General Medicine Authors: Victor L. Serebruany, Jean-Francois Tanguay, Wiktor Kuliczkowski, Eric Heidel, Moo Hyun Kim, Dan Atar Tags: Clinical Research Study Source Type: research
Frank's sign in a double stroke patient
A 72-year-old male, non-smoker, with a medical history of hypertension, hypercholesterolemia, atrial fibrillation and a past myocardial infarction 15 years ago, presented to the emergency department complaining about difficulty of speaking and left-hand weakness of 6-hour duration. Apart from an elevated blood pressure, at 170/100 mmHg, physical examination revealed dysarthria, accompanied by left brachial monoplegia and hypoesthesia. A bilateral earlobe wrinkle extending obliquely and backward, at a 45o angle, from the tragus to the edge of the auricle (Frank's sign) was observed (Figure 1A).
Source: The American Journal of Medicine - April 23, 2022 Category: General Medicine Authors: Konstantinos C. Christodoulou, Ioannis Stouras, Xafnoula Zlatidou, Despoina Kakagia Tags: Clinical Communication to the Editor Source Type: research
Polycythemia Vera Presenting as ST-Segment Elevation Myocardial Infarction
An 80-year-old woman with a history of hypertension, pre-diabetes, chronic kidney disease (stage 3b), and a remote ischemic stroke without residual deficits presented to the emergency department complaining of several hours of epigastric discomfort and malaise. An electrocardiogram (EKG) performed at triage revealed normal sinus rhythm with>1 mm ST segment elevation in leads V4-6 and lead 1, reciprocal ST depression in aVR, and Q waves in V1 and V2 (Figure 1). The troponin I was elevated to 1.66 ng/mL (reference range
Source: The American Journal of Medicine - March 31, 2022 Category: General Medicine Authors: Eric Hirsch, Lindor Qunaj, Azeem Latib, Benjamin Galen Tags: Diagnostic Dilemma Source Type: research
Statin Intolerance and Noncompliance: An Empiric Approach
Statins are among the most widely prescribed drugs. They reduce risk for atherosclerotic cardiovascular disease by lowering serum apolipoprotein B-containing lipoproteins, particularly low-density lipoprotein (LDL) cholesterol (LDL-C).1 Statins inhibit cholesterol synthesis in the liver, which increases expression of LDL receptors and lowers serum LDL-C.2 The latter slows progression of atherosclerotic lesions, reduces coronary plaque rupture, and decreases likelihood of acute cardiovascular syndromes (ie, myocardial infarction and stroke).
Source: The American Journal of Medicine - October 27, 2021 Category: General Medicine Authors: Scott M. Grundy, Gloria L. Vega Tags: Advancing High Value Health Care Source Type: research
The Reply
Dr. Jolobe, in his comments on our case study,1 is quite right in highlighting 2 pertinent examples of the potentially severe iatrogenic patient harm that may result from erroneous treatment of pauci-symptomatic acute type A aortic dissection masquerading and possibly misdiagnosed as an acute vascular event, be it ischemic stroke, acute myocardial infarction, or pulmonary thromboembolism.
Source: The American Journal of Medicine - August 1, 2021 Category: General Medicine Authors: Ami Schattner Tags: Letter Source Type: research
A comprehensive cardiovascular-renal-metabolic risk reduction approach to patients with Type 2 Diabetes Mellitus
Cardiovascular disease remains the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus, despite decades of research into risk reduction strategies (1,2). While myocardial infarction and ischemic stroke are the most recognized drivers of mortality in this population, less well-appreciated forms of cardiovascular disease, including heart failure and peripheral arterial disease, also contribute significantly to this risk (3-5). Further, the development of renal disease among patients with type 2 diabetes mellitus is common (6), and it drastically increases the risk of cardiovascular disease a...
Source: The American Journal of Medicine - May 21, 2021 Category: General Medicine Authors: Neha J. Pagidipati, Dr. Prakash Deedwania Tags: Review Source Type: research
Should Senior Citizens Take Aspirin Daily to Prevent Heart Attacks or Strokes?
More than one-half of Americans age 45 to 75 years take aspirin daily to prevent a stroke or a heart attack.1 Nearly half of US adults 75 years and older take daily aspirin even though they do not have a history of stroke or heart attack; they take it for the primary prevention of cardiovascular disease.2 Half of these individuals had discussed this with a physician.1 IS this a good or a bad idea? And how did the controversy surrounding the use of aspirin to prevent cardiovascular disease get started?
Source: The American Journal of Medicine - April 13, 2021 Category: General Medicine Authors: James E. Dalen, Robert J. Goldberg, Anna Waterbrook, Laura Wylie, Joseph S. Alpert Tags: Commentary Source Type: research
Should Senior Citizens Take Aspirin Daily to Prevent Heart Attacks or Strokes??
More than one-half of Americans aged 45 to 75 years take aspirin daily to prevent a stroke or a heart attack.1 Nearly half of American adults 75 years and older take daily aspirin even though they do not have a history of stroke or heart attack; they take it for the primary prevention of cardiovascular disease.2 Half of these individuals had discussed this with a physician.1 Was this a good or a bad idea? And how did the controversy surrounding the use of aspirin to prevent cardiovascular disease get started?
Source: The American Journal of Medicine - April 13, 2021 Category: General Medicine Authors: James E. Dalen, Robert Goldberg, Anna Waterbrook, Laura Wylie, Joseph S. Alpert Tags: COMMENTARY Source Type: research
Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle
Vasculogenic erectile dysfunction has been aptly called the “canary in the coal mine” for cardiovascular disease because it almost always precedes other manifestations of atherosclerotic cardiovascular disease, including myocardial infarction and stroke. It is common, associated with the presence of modifiable cardiovascular risk factors, and impacted by diet and lifestyle choices. This concise review provides an update on the use of dietary and other lifestyle interventions to improve vasculogenic erectile dysfunction and atherosclerotic cardiovascular disease.
Source: The American Journal of Medicine - November 20, 2020 Category: General Medicine Authors: Robert J. Ostfeld, Kathleen E. Allen, Karen Aspry, Eric J. Brandt, Aaron Spitz, Joshua Liberman, Danielle Belardo, James H. O'Keefe, Monica Aggarwal, Michael Miller, Columbus Batiste, Stephen Kopecky, Beth White, Nikhil Shah, Hussam Hawamdeh, Travis Batts Tags: Review Source Type: research
Vasculogenic Erectile Dysfunction - The Impact of Diet and Lifestyle
Vasculogenic erectile dysfunction has been aptly called the “canary in the coal mine” for cardiovascular disease as it almost always precedes other manifestations of atherosclerotic cardiovascular disease, including myocardial infarction and stroke. It is common, associated with the presence of modifiable cardiovascular risk factors, and impacted by diet and lifestyle choices. This concise review provides an update on the use of dietary and other lifestyle interventions to improve vasculogenic erectile dysfunction and atherosclerotic cardiovascular disease.
Source: The American Journal of Medicine - November 20, 2020 Category: General Medicine Authors: Robert J Ostfeld, Kathleen Allen, Karen Aspry, Eric J. Brandt, Aaron Spitz, Joshua Liberman, Danielle Belardo, James H. O'Keefe, Monica Aggarwal, Michael Miller, Columbus Batiste, Stephen Kopecky, Beth White, Nikhil Shah, Hussam Hawamdeh, Travis Batts, Ro Tags: Review Source Type: research
Corrigendum to “Effectiveness and Safety of Oral Anticoagulants in Adults with Non-valvular Atrial Fibrillation Patients and Concomitant Coronary/Peripheral Artery Disease” American Journal of Medicine 131:09 (2018): 1074-1085.e4
There were 33,269 apixaban-warfarin, 9,345 dabigatran-warfarin, and 42,156 rivaroxaban-warfarin matched pairs, with a median follow-up of 4-5 months. Compared with warfarin, apixaban was associated with lower rates of stroke/systemic embolism (hazard ratio [HR] 0.52; 95% confidence interval [95% CI], 0.43-0.62), major bleeding (HR 0.60; 95% CI, 0.55-0.66) and stroke/myocardial infarction/all-cause mortality (HR 0.70; 95%CI, 0.66-0.74); dabigatran was associated with lower rates of major bleeding (HR: 0.73; 95% CI, 0.62-0.85); dabigatran and rivaroxaban were associated with lower rates of stroke/myocardial infarction/all-ca...
Source: The American Journal of Medicine - August 4, 2020 Category: General Medicine Authors: Renato D. Lopes, Jan Steffel, Manuela Di Fusco, Allison Keshishian, Xuemei Luo, Xiaoyan Li, Cristina Masseria, Melissa Hamilton, Keith Friend, Kiran Gupta, Jack Mardekian, Xianying Pan, Onur Baser, W. Schuyler Jones Tags: Corrigendum Source Type: research
Infection as a trigger for cardiovascular disease
A variety of clinical infections including the current pandemic and a variety of physical events such as bee stings and trauma have been documented as triggers of acute cardiovascular illness such as venous thromboembolism, myocardial infarction, and stroke.1 –12 A number of factors have been proposed to explain this association between infection and acute cardiovascular disease including activation of various inflammatory molecules and platelets, endothelial dysfunction, and/or augmented sympathetic nervous activity with release of high levels of cate cholamines into the circulation.
Source: The American Journal of Medicine - July 6, 2020 Category: General Medicine Authors: Joseph S. Alpert Tags: Commentary Source Type: research
Albuminuria and Risk of Cardiovascular Events and Mortality in a General Population of Patients with Type 2 Diabetes without Cardiovascular Disease: A Danish Cohort Study
Albuminuria level is associated with cardiovascular events and mortality in patients with diabetes. However, little is known about the association between albuminuria level in diabetes patients without overt cardiovascular disease. We aimed to examine the association between albuminuria level and the risk of ischemic stroke, myocardial infarction, and all-cause mortality in patients with type 2 diabetes without overt cardiovascular disease.
Source: The American Journal of Medicine - March 19, 2020 Category: General Medicine Authors: Mia Vicki Fangel, Peter Br ønnum Nielsen, Jette Kolding Kristensen, Torben Bjerregaard Larsen, Thure Filskov Overvad, Gregory YH Lip, Martin Bach Jensen Tags: Clinical Research Study Source Type: research
