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Source: The American Journal of Medicine
Condition: Heart Attack

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Total 44 results found since Jan 2013.

Twenty-Five-Year (1986-2011) Trends in the Incidence and Death Rates of Stroke Complicating Acute Myocardial Infarction
The occurrence of a stroke after an acute myocardial infarction is associated with increased morbidity and mortality rates. However, limited data are available, particularly from a population-based perspective, about recent trends in the incidence and mortality rates associated with stroke complicating an acute myocardial infarction.The purpose of this study was to examine 25-year trends (1986-2011) in the incidence and in-hospital mortality rates of initial episodes of stroke complicating acute myocardial infarction.
Source: The American Journal of Medicine - May 3, 2018 Category: General Medicine Authors: Essa Hariri, Mayra Tisminetzky, Darleen Lessard, Jorge Yarzebski, Joel Gore, Robert Goldberg Tags: Clinical Research Study Source Type: research

Twenty-five year (1986-2011) trends in the incidence and death rates of stroke complicating acute myocardial infarction
: The occurrence of a stroke after an acute myocardial infarction is associated with increased morbidity and mortality. However, limited data are available, particularly from a population-based perspective, about recent trends in the incidence and death rates associated with stroke complicating an acute myocardial infarction.
Source: The American Journal of Medicine - May 3, 2018 Category: General Medicine Authors: Essa Hariri, Mayra Tisminetzky, Darleen Lassard, Jorge Yarzebski, Joel Gore, Robert Goldberg Source Type: research

Impact of Bleeding on Myocardial Infarction, Stroke and Death During 12-months Dual Antiplatelet Therapy After Acute Coronary Syndrome
One of the largest controversies of modern antithrombotic strategies is the uncertain relation among the potency and duration of dual antiplatelet therapy (DAPT) with associated bleeding rates1-3, and whether or not bleeding impacts mortality, myocardial infarction (MI) and stroke risks4-6. Some data from clinical trials1-5 and registries7,8 suggest that such a link is valid, however, this association is not established partly due to capturing of exclusively major or/and catastrophic events while omitting minor and minimal episodes, and applying restrictive bleeding scales9.
Source: The American Journal of Medicine - August 14, 2022 Category: General Medicine Authors: Victor L. Serebruany, Jean-Francois Tanguay, Wiktor Kuliczkowski, Eric Heidel, Moo Hyun Kim, Dan Atar Tags: Clinical Research Study Source Type: research

NSAID Use and Association with Cardiovascular Outcomes in Outpatients with Stable Atherothrombotic Disease
Abstract: Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin have been linked to heart failure, salt retention, adverse ventricular remodeling, and thrombosis. We therefore sought to assess their impact on cardiovascular events in outpatients with stable atherothrombotic disease.Methods: We analyzed 44,095 patients in the REduction of Atherothrombosis for Continued Health (REACH) registry with information on NSAID use and 4-year follow-up. Cox proportional hazard models, including NSAID use as a time-dependent covariate, were constructed and adjusted for key baseline characteristics. End points of...
Source: The American Journal of Medicine - November 25, 2013 Category: Journals (General) Authors: Payal Kohli, Ph. Gabriel Steg, Christopher P. Cannon, Sidney C. Smith, Kim A. Eagle, E. Magnus Ohman, Mark J. Alberts, Elaine Hoffman, Jianping Guo, Tabassome Simon, Emmanuel Sorbets, Shinya Goto, Deepak L. Bhatt, REACH Registry Investigators Tags: Clinical research studies Source Type: research

Aspirin in the Treatment and Prevention of Cardiovascular Disease: Past and Current Perspectives and Future Directions
Abstract: In secondary prevention among a wide range of patients who have survived a prior occlusive vascular event, as well as during acute myocardial infarction and acute occlusive stroke, aspirin produces statistically significant and clinically important reductions in the risk of subsequent myocardial infarction, stroke, and vascular death. In primary prevention, aspirin reduces risk of a first myocardial infarction, but the data on stroke and vascular deaths remain inconclusive. In addition, the average absolute risk of subjects randomized in the primary prevention trials was so low that it is not possible to get rel...
Source: The American Journal of Medicine - March 15, 2013 Category: Journals (General) Authors: Charles H. Hennekens, James E. Dalen Tags: Reviews Source Type: research

Vascular Risk Factors, Cardiovascular Disease, and Restless Legs Syndrome in Women
Conclusions: In this large cohort of female health professionals, various vascular risk factors are associated with the prevalence of restless legs syndrome. We could not confirm the results of previous reports indicating an association between prevalent cardiovascular disease and restless legs syndrome.
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Anke C. Winter, Markus Schürks, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Klaus Berger, Tobias Kurth Tags: Clinical research studies Source Type: research

Vascular Risk Factors, Cardiovascular Disease, and Restless Legs Syndrome in Men
Conclusions: The restless legs syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with restless legs syndrome. Prevalent stroke and myocardial infarction are related to restless legs syndrome prevalence.
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Anke C. Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth Tags: Clinical research studies Source Type: research

Functional Disability, Cognitive Impairment, and Depression After Hospitalization for Pneumonia
Conclusions: Hospitalization for pneumonia in older adults is associated with subsequent functional and cognitive impairment. Improved pneumonia prevention and interventions to ameliorate adverse sequelae during and after hospitalization may improve outcomes.
Source: The American Journal of Medicine - March 15, 2013 Category: Journals (General) Authors: Dimitry S. Davydow, Catherine L. Hough, Deborah A. Levine, Kenneth M. Langa, Theodore J. Iwashyna Tags: Clinical research studies Source Type: research

Corrigendum to “Effectiveness and Safety of Oral Anticoagulants in Adults with Non-valvular Atrial Fibrillation Patients and Concomitant Coronary/Peripheral Artery Disease” American Journal of Medicine 131:09 (2018): 1074-1085.e4
There were 33,269 apixaban-warfarin, 9,345 dabigatran-warfarin, and 42,156 rivaroxaban-warfarin matched pairs, with a median follow-up of 4-5 months. Compared with warfarin, apixaban was associated with lower rates of stroke/systemic embolism (hazard ratio [HR] 0.52; 95% confidence interval [95% CI], 0.43-0.62), major bleeding (HR 0.60; 95% CI, 0.55-0.66) and stroke/myocardial infarction/all-cause mortality (HR 0.70; 95%CI, 0.66-0.74); dabigatran was associated with lower rates of major bleeding (HR: 0.73; 95% CI, 0.62-0.85); dabigatran and rivaroxaban were associated with lower rates of stroke/myocardial infarction/all-ca...
Source: The American Journal of Medicine - August 4, 2020 Category: General Medicine Authors: Renato D. Lopes, Jan Steffel, Manuela Di Fusco, Allison Keshishian, Xuemei Luo, Xiaoyan Li, Cristina Masseria, Melissa Hamilton, Keith Friend, Kiran Gupta, Jack Mardekian, Xianying Pan, Onur Baser, W. Schuyler Jones Tags: Corrigendum Source Type: research

Impact of Severe Mitral Regurgitation on Postoperative Outcomes After Noncardiac Surgery
Abstract: Objective: Preoperative cardiac risk assessment scoring systems traditionally do not include valvular regurgitation as a criterion for adverse outcome prediction. We sought to determine the impact of significant mitral regurgitation on postoperative outcomes after planned noncardiac surgeries. Methods: Patients with significant mitral regurgitation (moderate-severe or severe) undergoing noncardiac surgery were identified using surgical and echocardiographic databases at the Cleveland Clinic. The mechanism of mitral regurgitation was identified and classified as ischemic or nonischemic. By using propensity sco...
Source: The American Journal of Medicine - April 15, 2013 Category: Journals (General) Authors: Navkaranbir S. Bajaj, Shikhar Agarwal, Anitha Rajamanickam, Akhil Parashar, Kanhaiya Lal Poddar, Brian P. Griffin, Thadeo Catacutan, E. Murat Tuzcu, Samir R. Kapadia Tags: Clinical research studies Source Type: research

Effectiveness and Safety of Anticoagulants in Adults with Non-valvular Atrial Fibrillation and Concomitant Coronary/Peripheral Artery Disease
Atrial fibrillation increases the risk of stroke by five-fold and is associated with 15-20% of all strokes.1,2 Prior studies have shown that the prevalence of coronary artery disease and peripheral artery disease among atrial-fibrillation-diagnosed patients ranges from 18-45%, and 4-17%, respectively.3 –9 Coronary and peripheral artery disease patients are at high risk for stroke, myocardial infarction, and cardiovascular-related death.10–13 Concomitant atrial fibrillation with coronary artery disease is associated with all-cause mortality, coronary death, and major coronary events.
Source: The American Journal of Medicine - May 26, 2018 Category: General Medicine Authors: Renato D. Lopes, Jan Steffel, Manuela Di Fusco, Allison Keshishian, Xuemei Luo, Xiaoyan Li, Cristina Masseria, Melissa Hamilton, Keith Friend, Kiran Gupta, Jack Mardekian, Xianying Pan, Onur Baser, W. Schuyler Jones Tags: Clinical Research Study Source Type: research

Should Senior Citizens Take Aspirin Daily to Prevent Heart Attacks or Strokes??
More than one-half of Americans aged 45 to 75 years take aspirin daily to prevent a stroke or a heart attack.1 Nearly half of American adults 75 years and older take daily aspirin even though they do not have a history of stroke or heart attack; they take it for the primary prevention of cardiovascular disease.2 Half of these individuals had discussed this with a physician.1 Was this a good or a bad idea? And how did the controversy surrounding the use of aspirin to prevent cardiovascular disease get started?
Source: The American Journal of Medicine - April 13, 2021 Category: General Medicine Authors: James E. Dalen, Robert Goldberg, Anna Waterbrook, Laura Wylie, Joseph S. Alpert Tags: COMMENTARY Source Type: research

Should Senior Citizens Take Aspirin Daily to Prevent Heart Attacks or Strokes?
More than one-half of Americans age 45 to 75 years take aspirin daily to prevent a stroke or a heart attack.1 Nearly half of US adults 75 years and older take daily aspirin even though they do not have a history of stroke or heart attack; they take it for the primary prevention of cardiovascular disease.2 Half of these individuals had discussed this with a physician.1 IS this a good or a bad idea? And how did the controversy surrounding the use of aspirin to prevent cardiovascular disease get started?
Source: The American Journal of Medicine - April 13, 2021 Category: General Medicine Authors: James E. Dalen, Robert J. Goldberg, Anna Waterbrook, Laura Wylie, Joseph S. Alpert Tags: Commentary Source Type: research

Inflammatory bowel disease and cardiovascular diseases
Inflammatory Bowel Disease is comprised of two major subtypes: Crohn's disease and ulcerative colitis, characterized by chronic inflammation of the gastrointestinal tract with extraintestinal manifestations that can involve a number of systems.1 There were estimated to be 7 million cases of inflammatory bowel disease globally in 2017, and at the national level, the United States had the highest age-standardized prevalence rate (464.5 per 100,000 population) of inflammatory bowel disease.2 Atherosclerotic cardiovascular diseases is defined as a history of acute coronary syndrome, myocardial infarction, stable or unstable an...
Source: The American Journal of Medicine - September 1, 2022 Category: General Medicine Authors: Bing Chen, Lauren V Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Edward V. Loftus, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J Lavie, Chayakrit Krittanawong Tags: Clinical Research Study Source Type: research

Emerging Clinical Challenges in the Use of Statins
In randomized trials and meta-analyses, statins decrease myocardial infarction, stroke, vascular death, and total mortality. The totality of evidence indicates no threshold below which there are no net benefits, including primary prevention subjects at low risk. In this commentary, we present some consequent new and emerging clinical challenges.
Source: The American Journal of Medicine - June 19, 2013 Category: Journals (General) Authors: Charles H. Hennekens, Nicolas R. Breuer, Ira J. Gelb, David J. Bjorkman, Jeffrey S. Borer, Marc A. Pfeffer Tags: Commentary Source Type: research