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Contemporary Meta-Analysis of Extended Direct Acting Oral Anticoagulant Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients
There are over 36 million medical hospitalizations each year in the United States, with the majority being for acute medical illness.1 Cancer, chronic obstructive pulmonary disease, congestive heart failure, stroke and myocardial infarction are some of the most common indications for hospitalization and are additionally risk factors for venous thromboembolism.2 With over 900,000 patients suffering from venous thromboembolism each year, excess thrombosis causes a large medical and financial burden to patients and the health care system.
Source: The American Journal of Medicine - March 5, 2020 Category: General Medicine Authors: Vikas Bhalla, Olivia F Lamping, Ahmed Abdel-Latif, Meenakshi Bhalla, Khaled Ziada, Susan S. Smyth Tags: Clinical Research Study Source Type: research

Predictors of not initiating anticoagulation after incident venous thromboembolism: a Danish nationwide cohort study
Venous thromboembolism, com prising deep vein thrombosis and pulmonary embolism, is the third most common cause of cardiovascular death after stroke and myocardial infarction.1 Anticoagulation is the keystone in venous thromboembolism treatment and prevention of venous thromboembolism morbidity, mortality, and recurrence. International guidelines mandate anticoagulant therapy for a minimum of 3 months after proximal deep vein thrombosis and/or pulmonary embolism.2,3
Source: The American Journal of Medicine - October 9, 2019 Category: General Medicine Authors: Ida Ehlers Albertsen, Samuel Zachary Goldhaber, Gregory Piazza, Thure Filskov Overvad, Peter Br ønnum Nielsen, Torben Bjerregaard Larsen, Mette Søgaard Tags: Clinical Research Study Source Type: research

Cardiovascular and cerebrovascular safety of testosterone replacement therapy among aging men with low testosterone levels: a cohort study
We assessed the risk of ischemic stroke, transient ischemic attack, and myocardial infarction associated with testosterone replacement therapy (TRT) among aging men with low testosterone levels.
Source: The American Journal of Medicine - April 2, 2019 Category: General Medicine Authors: Simone Y. Loo, Laurent Azoulay, Rui Nie, Sophie Dell'Aniello, Oriana Hoi Yun Yu, Christel Renoux Tags: Clinical Research Study Source Type: research

Effectiveness and Safety of Anticoagulants in Adults with Non-valvular Atrial Fibrillation and Concomitant Coronary/Peripheral Artery Disease
Atrial fibrillation increases the risk of stroke by five-fold and is associated with 15-20% of all strokes.1,2 Prior studies have shown that the prevalence of coronary artery disease and peripheral artery disease among atrial-fibrillation-diagnosed patients ranges from 18-45%, and 4-17%, respectively.3 –9 Coronary and peripheral artery disease patients are at high risk for stroke, myocardial infarction, and cardiovascular-related death.10–13 Concomitant atrial fibrillation with coronary artery disease is associated with all-cause mortality, coronary death, and major coronary events.
Source: The American Journal of Medicine - May 26, 2018 Category: General Medicine Authors: Renato D. Lopes, Jan Steffel, Manuela Di Fusco, Allison Keshishian, Xuemei Luo, Xiaoyan Li, Cristina Masseria, Melissa Hamilton, Keith Friend, Kiran Gupta, Jack Mardekian, Xianying Pan, Onur Baser, W. Schuyler Jones Tags: Clinical Research Study Source Type: research

Arterial Ischemic Events Are a Major Complication in Cancer Patients with Venous Thromboembolism
A number of studies revealed that patients with venous thromboembolism are at increased risk of developing subsequent arterial ischemic events, such as myocardial infarction or stroke.1 –8 Prevention of such arterial ischemic events in addition to treating venous thromboembolismmay warrant combination therapy with antiplatelets and anticoagulants. Recent studies suggested an increased risk of arterial ischemic events in cancer patients.9,10 Accurate identification of patients at increased risk for arterial ischemic events during the course of anticoagulation for venous thromboembolismmay help to select those who would po...
Source: The American Journal of Medicine - May 26, 2018 Category: General Medicine Authors: Benjamin Brenner, Behnood Bikdeli, Inna Tzoran, Olga Madridano, Raquel L ópez-Reyes, José María Suriñach, Ángeles Blanco-Molina, Antonella Tufano, Juan José López Núñez, Javier Trujillo-Santos, Manuel Monreal, for the RIETE Investigators Tags: Clinical Research Study Source Type: research

Twenty-Five-Year (1986-2011) Trends in the Incidence and Death Rates of Stroke Complicating Acute Myocardial Infarction
The occurrence of a stroke after an acute myocardial infarction is associated with increased morbidity and mortality rates. However, limited data are available, particularly from a population-based perspective, about recent trends in the incidence and mortality rates associated with stroke complicating an acute myocardial infarction.The purpose of this study was to examine 25-year trends (1986-2011) in the incidence and in-hospital mortality rates of initial episodes of stroke complicating acute myocardial infarction.
Source: The American Journal of Medicine - May 3, 2018 Category: General Medicine Authors: Essa Hariri, Mayra Tisminetzky, Darleen Lessard, Jorge Yarzebski, Joel Gore, Robert Goldberg Tags: Clinical Research Study Source Type: research

Twenty-five year (1986-2011) trends in the incidence and death rates of stroke complicating acute myocardial infarction
: The occurrence of a stroke after an acute myocardial infarction is associated with increased morbidity and mortality. However, limited data are available, particularly from a population-based perspective, about recent trends in the incidence and death rates associated with stroke complicating an acute myocardial infarction.
Source: The American Journal of Medicine - May 3, 2018 Category: General Medicine Authors: Essa Hariri, Mayra Tisminetzky, Darleen Lassard, Jorge Yarzebski, Joel Gore, Robert Goldberg Source Type: research

Diet Redux: Which Food Type Leads to Heart Attacks?
No topic has been more hotly debated over recent decades than the role of various foods in the development of atherosclerosis. The earliest animal experiments demonstrated that diets rich in fat and cholesterol produced arterial lesions that resembled atherosclerosis in humans1. Over subsequent decades, a great deal of animal and human research has been performed exploring the concept that dietary composition is related to the development of atherosclerosis. The earliest theories followed the direction of the early animal experiments mentioned above: These investigations demonstrated that diets containing large amounts of ...
Source: The American Journal of Medicine - April 20, 2018 Category: General Medicine Authors: Joseph S. Alpert Tags: Commentary Source Type: research

Cardiovascular Protection in the Treatment of Type 2 Diabetes: A Review of Clinical Trial Results Across Drug Classes
Patients with type 2 diabetes (T2DM) have a significantly higher risk of developing cardiovascular disease (CVD) —namely myocardial infarction, heart failure, and stroke. Despite clear advances in the prevention and treatment of CVD, the impact of T2DM on CVD outcome remains high and continues to escalate. Available evidence indicates that the risk of macrovascular complications increases with the severity o f hyperglycemia, thus suggesting that the relation between metabolic disturbances and vascular damage is approximately linear.
Source: The American Journal of Medicine - May 26, 2017 Category: General Medicine Authors: Francesco Paneni, Thomas F. L üscher Tags: Clinical research study Source Type: research

The Limited Public Health Impact of ‘Lifestyle’ Change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice,” but better described as a “habit.” The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready-to-consume food and drink, much of which is manufactured on an industrial scale. Collectively, these dietar y components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

The limited public health impact of “lifestyle” change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice”, but better described as a “habit”. The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready to consume food and drink, much of which is manufactured on an industrial scale. Collectively these dietary components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

Thrombolysis; a critical first-line therapy with an unfulfilled potential
A blood clot or thrombus triggers the onset of most vascular diseases, like stroke or heart attack. Thrombolysis is the only treatment that can restore blood flow rapidly and easily. Unfortunately, the standard thrombolytic, tissue plasminogen activator (tPA), has proven inadequate and is being replaced by invasive endovascular procedures, which are time-consuming and limited in their availability in relation to the scope of the problem. Historically, when tPA clinical trials began, it was insufficiently recognized that without the other natural plasminogen activator, prourokinase (proUK), thrombolysis by tPA was seriously compromised.
Source: The American Journal of Medicine - December 20, 2015 Category: Journals (General) Authors: Victor Gurewich Tags: Review Source Type: research

Thrombolysis: A Critical First-Line Therapy with an Unfulfilled Potential
A blood clot or thrombus triggers the onset of most vascular diseases, like stroke or heart attack. Thrombolysis is the only treatment that can restore blood flow rapidly and easily. Unfortunately, the standard thrombolytic, tissue plasminogen activator (tPA), has proven inadequate and is being replaced by invasive endovascular procedures, which are time consuming and limited in their availability in relation to the scope of the problem. Historically, when tPA clinical trials began, it was not recognized sufficiently that without the other natural plasminogen activator, prourokinase (proUK), thrombolysis by tPA was seriously compromised.
Source: The American Journal of Medicine - December 20, 2015 Category: Journals (General) Authors: Victor Gurewich Tags: Review Source Type: research

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