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Source: ASAIO Journal

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Total 95 results found since Jan 2013.

Permanent Continuous Flow Left Ventricular Assist Devices Use After Acute Stabilization for Cardiogenic Shock in Acute Myocardial Infarction
This study suggests CF-LVADs are potential but high-risk treatment options for CS-AMI patients who stabilize with temporary support. Further studies will help more clearly delineate the benefits and risks of CF-LVAD implant in this population.
Source: ASAIO Journal - February 25, 2017 Category: Medical Equipment Tags: Case Reports Source Type: research

Endovascular Stenting of a LVAD Outflow Graft Thrombosis
This report highlights the importance of simultaneous prevention of stroke using filter devices in the common carotid arteries.
Source: ASAIO Journal - December 30, 2016 Category: Medical Equipment Tags: Case Reports Source Type: research

Distinct Effects of Left or Right Atrial Cannulation on Left Ventricular Hemodynamics in a Swine Model of Acute Myocardial Injury
We examined the effects of right atrial to femoral artery (RA–FA; VA-ECMO) bypass versus left atrial to femoral artery (LA–FA; TandemHeart) bypass using a centrifugal pump (Cardiac Assist Inc, Pittsburgh, PA) on LV hemodynamics in a swine model of acute LV injury. In eight male swine, the RA–FA bypass group employed a 21 Fr inflow cannula in the right atrial (RA) and a 17 Fr FA outflow cannula. The LA–FA bypass group employed a 21 Fr inflow cannula in the LA and a 17 Fr FA outflow cannula. Both pump configurations were activated at 3,500 rotations per minute (RPMs) followed by balloon angioplasty-mediated occlusion...
Source: ASAIO Journal - November 1, 2016 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices
In conclusion, higher preimplant RDW is independently associated with an increased risk of postimplant mortality and infection. Future studies are needed to understand the prognostic ability of RDW and to understand the biologic mechanism underlying this association.
Source: ASAIO Journal - November 1, 2016 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

In Vivo Evaluation of a Pneumatic Extracorporeal Ventricular Assist Device for up to 90 Day Support
This study shows that the EVAD-P can provide safe pulsatile mechanical circulatory support (MCS) for up to 93 days. To further confirm that the system can consistently provide MCS for this duration, additional studies are recommended.
Source: ASAIO Journal - November 1, 2016 Category: Medical Equipment Tags: Clinical Cardiovascular Source Type: research

Experimental Venoarterial Extracorporeal Membrane Oxygenation Induces Left Ventricular Dysfunction
In conclusion, VA-ECMO increased LV volumes and reduced LV function, irrespective of cannulation site in this experimental model. Reduced LV ejection fraction and stroke work indicated LV dysfunction during ECMO.
Source: ASAIO Journal - August 27, 2016 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Outcomes of Various Treatment Strategies for Patients with Continuous-Flow Ventricular Assist Device Thrombosis: A Retrospective Analysis
Pump thrombosis is associated with high morbidity and mortality in patients with a continuous-flow left ventricular assist device. Although it has been defined clearly, the diagnosis and treatment of this complication still remain controversial. Between 2010 and 2014, 163 consecutive patients (mean age: 50.7 ± 13 years, 84% males, median duration of support: 277 (2–1077) days) were implanted a continuous-flow left ventricular assist device. Prospectively collected data of all patients who had at least one pump thrombosis event have been analyzed, retrospectively. Twenty-one pump thrombosis events were observed in 15...
Source: ASAIO Journal - August 27, 2016 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Patients Awaiting Heart Transplantation on HVAD Support for Greater Than 2 Years
Advanced heart failure patients who are classified as bridge to transplant (BTT) often remain on mechanical circulatory support (MCS) for long durations because of the limited supply of donor organs. Here, we present the outcomes of patients who have been supported by the HeartWare ventricular assist device system for more than 2 years. In the HeartWare BTT and continued access protocol trial, 74 of the 382 total patients (19.4%) had more than 2 years of MCS with a mean time of 1,045 days on device. The long-term group was more frequently female, was nonwhite, and had Interagency Registry for Mechanically Assisted Circulat...
Source: ASAIO Journal - June 30, 2016 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

The Influence of Different Operating Conditions on the Blood Damage of a Pulsatile Ventricular Assist Device
Because of pulsatile blood flow’s benefit for myocardial recovery, perfusion of coronary arteries and end organs, pulsatile ventricular assist devices (VADs) are still widely used as paracorporeal mechanical circulatory support devices in clinical applications, especially in pediatric heart failure patients. However, severe blood damage limits the VAD’s service period. Besides optimizing the VAD geometry to reduce blood damage, the blood damage may also be decreased by changing the operating conditions. In this article, a pulsatile VAD was used to investigate the influence of operating conditions on its blood damage, i...
Source: ASAIO Journal - November 1, 2015 Category: Medical Equipment Tags: Biomedical Engineering Source Type: research

Feasibility of Pump Speed Modulation for Restoring Vascular Pulsatility with Rotary Blood Pumps
Continuous flow (CF) left ventricular assist devices (LVAD) diminish vascular pressure pulsatility, which may be associated with clinically reported adverse events including gastrointestinal bleeding, aortic valve insufficiency, and hemorrhagic stroke. Three candidate CF LVAD pump speed modulation algorithms designed to augment aortic pulsatility were evaluated in mock flow loop and ischemic heart failure (IHF) bovine models by quantifying hemodynamic performance as a function of mean pump speed, modulation amplitude, and timing. Asynchronous and synchronous copulsation (high revolutions per minute [RPM] during systole, lo...
Source: ASAIO Journal - September 1, 2015 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Programmed Speed Reduction Enables Aortic Valve Opening and Increased Pulsatility in the LVAD-Assisted Heart
Aortic valve opening (AVO) during left ventricular assist device (LVAD) support aids in preventing valve fusion, incompetence, and thrombosis. The programmed low speed algorithm (PLSA) allows AVO intermittently by reducing continuous motor speed during a dwell time. AVO and hemodynamics in the LVAD-assisted heart were measured using a HeartMate II (Thoratec Corporation, Pleasanton, CA) LVAD with a PLSA controller in a mock circulatory loop. Left ventricle and aortic pressures, LVAD, and total aortic flow were measured during pre-LVAD, non-PLSA and PLSA combinations of cardiac function, and LVAD speed. The low cardiac setti...
Source: ASAIO Journal - September 1, 2015 Category: Medical Equipment Tags: Biomedical Engineering Source Type: research

Prophylactic Subclavian Artery Intraaortic Balloon Counter-Pulsation is Safe in High-Risk Cardiac Surgery Patients
The objective of this study was to determine the safety of prophylactic subclavian artery intraaortic balloon pumps (SCA-IABP) in high-risk cardiac surgery patients as a bridge to recovery (BTR). From November 2011 to January 2013, 11 consecutive patients at three institutions underwent prophylactic insertion of a SCA-IABP as a BTR. All patients (n = 11) had preoperative ejection fractions of 30% or less. Patients concurrently underwent one or a combination of the following procedures: coronary artery bypass grafting, mitral valve surgery, aortic valve replacement, left ventricular aneurysm resection, and ventricular/atria...
Source: ASAIO Journal - September 1, 2015 Category: Medical Equipment Tags: Case Series Source Type: research

Readmissions After Continuous Flow Left Ventricular Assist Device Implantation: Differences Observed Between Two Contemporary Device Types
Readmissions after continuous flow left ventricular assist devices implantation are common. We compared the frequency and etiology of readmissions between two continuous flow left ventricular assist devices 6 months after implant. We retrospectively assessed readmissions in 81 patients who received a bridge to transplant HeartMate-II (HM-II) n = 35, 43% or HeartWare (HW) n = 46, 57%, from 2009 to 2014. Readmissions were divided into cardiac, infection, gastrointestinal bleeding, stroke, pump thrombosis, and miscellaneous profiles. Age, gender, creatinine, INTERMACS profiles were comparable between groups (p> 0.05). Sixty-o...
Source: ASAIO Journal - July 1, 2015 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Preservation of Native Aortic Valve Flow and Full Hemodynamic Support with the TORVAD Using a Computational Model of the Cardiovascular System
This article describes the stroke volume selection and operational design for the toroidal ventricular assist device (TORVAD), a synchronous, positive-displacement ventricular assist device (VAD). A lumped parameter model was used to simulate hemodynamics with the TORVAD compared with those under continuous-flow VAD support. Results from the simulation demonstrated that a TORVAD with a 30 ml stroke volume ejecting with an early diastolic counterpulse provides comparable systemic support to the HeartMate II (HMII) (cardiac output 5.7 L/min up from 3.1 L/min in simulated heart failure). By taking the advantage of synchronous...
Source: ASAIO Journal - May 1, 2015 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Lessons Learned from 150 Continuous-Flow Left Ventricular Assist Devices: A Single Institutional 7 Year Experience
Continuous-flow (CF) left ventricular assist devices (LVADs) have become the standard of care for patients with advanced heart failure refractory to optimal medical therapy. The goal of this study was to review our 7 year single institutional experience with CF LVADs. Mean age was 50.4 + 12.5 (17–69) years for bridge-to-transplantation (BTT) patients and 57.6 + 10.4 (31–81) years for destination therapy (DT) patients (p
Source: ASAIO Journal - May 1, 2015 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research