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Source: American Heart Journal
Education: Study
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Total 295 results found since Jan 2013.
Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: Study design and conduct
Conclusions: Comprehensive procedures were used for rigorous event reascertainment and readjudication in a previously completed open-label, global clinical trial. These procedures used in this unique situation were consistent with other common approaches in the field, were enhanced to address the FDA concerns about the original RECORD trial results, and could be considered by clinical trialists designing event readjudication protocols for drug development programs that have been completed.
Source: American Heart Journal - June 24, 2013 Category: Cardiology Authors: Renato D. Lopes, Sheila Dickerson, Gail Hafley, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L. Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D. Home, Kenneth W. Mahaffey Tags: Trial Design Source Type: research
Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis
Background: Inflammation plays a fundamental role in atherothrombosis. Yet, whether direct inhibition of inflammation will reduce the occurrence of adverse cardiovascular outcomes is not known.Design: The Cardiovascular Inflammation Reduction Trial (CIRT) (ClinicalTrials.gov NCT01594333) will randomly allocate 7,000 patients with prior myocardial infarction (MI) and either type 2 diabetes or the metabolic syndrome to low-dose methotrexate (target dose 15-20 mg/wk) or placebo over an average follow-up period of 3 to 5 years. Low-dose methotrexate is a commonly used anti-inflammatory regimen for the treatment of rheumatoid a...
Source: American Heart Journal - May 6, 2013 Category: Cardiology Authors: Brendan M. Everett, Aruna D. Pradhan, Daniel H. Solomon, Nina Paynter, Jean MacFadyen, Elaine Zaharris, Milan Gupta, Michael Clearfield, Peter Libby, Ahmed A.K. Hasan, Robert J. Glynn, Paul M. Ridker Tags: Trial Design Source Type: research
Effect of atrioventricular and ventriculoventricular delay optimization on clinical and echocardiographic outcomes of patients treated with cardiac resynchronization therapy: A meta-analysis
Conclusion: The current literature suggests that routine AV and/or VV delay optimization has a neutral effect on clinical and echocardiographic outcomes based on pooled data from randomized and nonrandomized studies. Standardization of patient selection and optimization timing and method may help to further define the role of CRT device optimization.
Source: American Heart Journal - May 2, 2013 Category: Cardiology Authors: Dominique Auger, Ulas Hoke, Jeroen J. Bax, Eric Boersma, Victoria Delgado Tags: Curriculum in Cardiology Source Type: research
Risk of stroke with percutaneous coronary intervention compared with on-pump and off-pump coronary artery bypass graft surgery: Evidence from a comprehensive network meta-analysis
Conclusions: Percutaneous coronary intervention is associated with lower 30-day rates of stroke than both off-pump and on-pump CABG. Further studies are required to determine whether the risk of stroke is reduced with off-pump CABG compared with on-pump CABG.
Source: American Heart Journal - April 25, 2013 Category: Cardiology Authors: Tullio Palmerini, Giuseppe Biondi-Zoccai, Diego Della Riva, Andrea Mariani, Carlo Savini, Marco Di Eusanio, Philippe Genereux, Giacomo Frati, Antonino G.M. Marullo, Giovanni Landoni, Teresa Greco, Angelo Branzi, Stefano De Servi, Germano Di Credico, Nevio Tags: Curriculum in Cardiology Source Type: research
Temporal trends in sudden unexpected death in a general population: The Hisayama Study
Background: Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited.Methods: Among a total of 1934 residents aged ≥20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5%) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours.Results: The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1% in 1962-1973, 13.4% in 1974-1985, 15.0% in 1986-1997, and 14.6% in 19...
Source: American Heart Journal - April 8, 2013 Category: Cardiology Authors: Masaharu Nagata, Toshiharu Ninomiya, Yasufumi Doi, Jun Hata, Fumie Ikeda, Naoko Mukai, Kazuhiko Tsuruya, Yoshinao Oda, Takanari Kitazono, Yutaka Kiyohara Tags: Acute Ischemic Heart Disease Source Type: research
The outcome of intra-aortic balloon pump support in acute myocardial infarction complicated by cardiogenic shock according to the type of revascularization: A comprehensive meta-analysis
Aims: Despite the recommendations of the current guidelines, scientific evidence continue to challenge the effectiveness of intra-aortic balloon pump (IABP) in acute myocardial infarction (AMI) complicated by cardiogenic shock. Moreover, 2 recent meta-analyses showed contrasting results. The aim of this study is to test the effect of IABP according to the type of therapeutic treatment of AMI: percutaneous coronary intervention (PCI), thrombolytic therapy (TT), or medical therapy without reperfusion. Articles published from January 1, 1986, to December 31, 2012, were collected and analyzed by meta-analysis.Methods and resul...
Source: American Heart Journal - March 27, 2013 Category: Cardiology Authors: Francesco Romeo, Maria Cristina Acconcia, Domenico Sergi, Alessia Romeo, Saverio Muscoli, Serafina Valente, Gian Franco Gensini, Flavia Chiarotti, Quintilio Caretta Tags: Curriculum in Cardiology Source Type: research
Transradial percutaneous coronary intervention in cardiogenic shock: A single-center experience
Conclusions: Transradial approach for PCI is possible and safe in up to two-thirds of patients with CS. Absence of radial pulse was the main factor preventing use of TRA. In multivariate analysis, TRA was associated with a lower risk of mortality.
Source: American Heart Journal - March 1, 2013 Category: Cardiology Authors: Oriol Rodriguez-Leor, Eduard Fernandez-Nofrerias, Xavier Carrillo, Josepa Mauri, Carolina Oliete, Maria del Carmen Rivas, Antoni Bayes-Genis Tags: Transradial Angiography and Intervention Source Type: research
Outcome and safety of same-day-discharge percutaneous coronary interventions with femoral access: A single-center experience
Conclusions: Same-day-discharge after uncomplicated PCI using femoral access is safe when patients are properly selected. The strategy may improve and benefit health costs in the future.
Source: American Heart Journal - January 28, 2013 Category: Cardiology Authors: Lisbeth Antonsen, Lisette Okkels Jensen, Per Thayssen Tags: Interventional Cardiology Source Type: research
Ischemic stroke associated with left cardiac catheterization: The importance of modifiable and non-modifiable risk factors
Background: Stroke associated with left cardiac catheterization is a devastating complication, and its incidence has not changed over the decades.We investigated the incidence, in-hospital outcomes and the modifiable and non-modifiable risk factors for periprocedural ischemic stroke.Methods: Our retrospective cohort study included all patients experiencing periprocedural ischemic stroke among the 24,500 patients who underwent left cardiac catheterization between January 2003 and October 2010. The case group was compared with a group of control patients randomly selected among those who underwent the procedure during this p...
Source: American Heart Journal - January 21, 2013 Category: Cardiology Authors: Batric Popovic, Sylvain Carillo, Nelly Agrinier, Charles Christophe, Christine Selton-Suty, Yves Juillière, Etienne Aliot Tags: Interventional Cardiology Source Type: research
INtensive versus Standard Ambulatory Blood Pressure Lowering to Prevent Functional DeclINe In The ElderlY (INFINITY)
Reductions in mobility and cognitive function linked to accrual of brain microvascular disease related white matter hyperintensities (WMHs) on magnetic resonance imaging can occur in older hypertensive patients in as little as 2 years. We have designed a trial evaluating 2 levels of ambulatory blood pressure (ABP) control in individuals with normal or mildly impaired mobility and cognition who have detectable cerebrovascular disease (>0.5% WMH fraction of intracranial volume) on functional outcomes. The study is a prospective randomized, open-label trial with blinded end points, in patients ages ≥75 years with elevated 2...
Source: American Heart Journal - January 7, 2013 Category: Cardiology Authors: William B. White, Ravi Marfatia, Julia Schmidt, Dorothy B. Wakefield, Richard F. Kaplan, Richard W. Bohannon, Charles B. Hall, Charles R. Guttmann, Nicola Moscufo, Douglas Fellows, Leslie Wolfson Tags: Trial Design Source Type: research
