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Source: Clinical Research in Cardiology

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Total 257 results found since Jan 2013.

Three-year efficacy and safety of new- versus early-generation drug-eluting stents for unprotected left main coronary artery disease insights from the ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 trials
Conclusions At 3-year follow-up, a PCI with new-generation DES for uLMCA disease shows comparable efficacy to early-generation DES. Rates of stent thrombosis were low in both groups. Diabetes significantly impacts the risk of MACCE at 3 years in patients treated with new-generation DES for uLMCA disease. ClinicalTrials.gov Identifiers: NCT00133237; NCT00598637.
Source: Clinical Research in Cardiology - December 22, 2015 Category: Cardiology Source Type: research

β-Blockers and ivabradine differentially affect cardiopulmonary function and left ventricular filling index
Conclusions In patients with CAD and elevated E/e′, switching therapy from β-blockers to ivabradine may cause a reduction in LV filling pressures and an improved stroke volume response to exercise.
Source: Clinical Research in Cardiology - December 19, 2015 Category: Cardiology Source Type: research

Deep sedation versus general anesthesia in percutaneous edge-to-edge mitral valve reconstruction using the MitraClip system
Conclusions In comparison to GA, DS reduces the ICU length of stay in PMVR without negative effects on safety and efficacy. Prospective randomized trials are needed to confirm these findings.
Source: Clinical Research in Cardiology - December 18, 2015 Category: Cardiology Source Type: research

Impact of income status on prognosis of acute coronary syndrome patients during Greek financial crisis
Conclusions In a period of financial crisis, low income is a significant and independent predictor of poor out-of-hospital outcome in ACS patients. This association has profound implications and should be taken into consideration by public health policy makers.
Source: Clinical Research in Cardiology - December 10, 2015 Category: Cardiology Source Type: research

Neurological damage after transcatheter aortic valve implantation compared with surgical aortic valve replacement in intermediate risk patients
Conclusions TAVI and SAVR were associated with a similar rate of acute silent ischemic cerebral lesions in intermediate risk patients. Although acute lesions occurred very frequently in both strategies, their cognitive impact was not clinically relevant.
Source: Clinical Research in Cardiology - December 8, 2015 Category: Cardiology Source Type: research

Polypharmacy and major adverse events in atrial fibrillation: observations from the AFFIRM trial
Conclusions Polypharmacy is highly prevalent in AF patients and associated with a worse clinical outcome, conferring 30 % excess relative risk for CV death. Thus, polypharmacy may be a health status marker. Strategies to reduce inappropriate prescription and polypharmacy should be tested in prospective longitudinal studies of AF patients.
Source: Clinical Research in Cardiology - November 2, 2015 Category: Cardiology Source Type: research

Safety of percutaneous coronary intervention in patients with acute ischemic stroke/transient ischemic attack and acute coronary syndrome
Conclusions The primary and secondary end points were not enhanced in patients undergoing PCI. Therefore PCI is safe in patients with stroke/TIA and concomitant ACS.
Source: Clinical Research in Cardiology - October 29, 2015 Category: Cardiology Source Type: research

Atrial fibrillation and hypertrophic cardiomyopathy: who to anticoagulate?
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac conditions. Atrial fibrillation (AF) has been demonstrated to be the most frequent arrhythmia encountered in HCM patients. Research focusing on AF and embolic stroke in HCM patients has been sparse and the sample size of most studies is small. The prognostic significance of AF in HCM patients is still not well known. The aim of this article is to provide further understanding of the anti-coagulation requirement of HCM patients with AF.
Source: Clinical Research in Cardiology - October 1, 2015 Category: Cardiology Source Type: research

Efficacy and safety of novel oral anticoagulants in patients with bioprosthetic valves
Conclusion The use of NOAC therapy for AF in patients with bioprosthetic valves appears safe and effective in the occurrence of thromboembolic events, however, at the expense of increased bleeding. Larger studies are necessary to confirm these findings.
Source: Clinical Research in Cardiology - September 18, 2015 Category: Cardiology Source Type: research

Efficacy and safety of percutaneous left atrial appendage closure to prevent thromboembolic events in atrial fibrillation patients with high stroke and bleeding risk
Conclusion Left atrial appendage closure in patients with non-valvular atrial fibrillation and high risk for stroke and bleeding events effectively prevented stroke and reduced cerebral ischemic events compared to expected stroke rate according to CHA2DS2-VASc Score. Dual antiplatelet therapy for 3 months reduced the rate of bleeding events compared to 6 months therapy with no increase of thrombotic events.
Source: Clinical Research in Cardiology - August 29, 2015 Category: Cardiology Source Type: research

Invasive hemodynamic assessments during transcatheter aortic valve implantation: comparison of patient outcomes in higher vs. lower transvalvular gradients with respect to left ventricular ejection fraction
Conclusion The higher mortality in patients with CLFLG AS reflects an advanced disease state, possibly indicating a futile condition before TAVI. Nevertheless, high procedural success rates and a functional improvement in nearly all survivors support the concept of TAVI.
Source: Clinical Research in Cardiology - July 16, 2015 Category: Cardiology Source Type: research

Atrial fibrillation and hypertrophic cardiomyopathy: who to anticoagulate?
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac conditions. Atrial fibrillation (AF) has been demonstrated to be the most frequent arrhythmia encountered in HCM patients. Research focusing on AF and embolic stroke in HCM patients has been sparse and the sample size of most studies is small. The prognostic significance of AF in HCM patients is still not well known. The aim of this article is to provide further understanding of the anti-coagulation requirement of HCM patients with AF.
Source: Clinical Research in Cardiology - July 2, 2015 Category: Cardiology Source Type: research

Quantitative assessment of atrial conduit function: a new index of diastolic dysfunction
Conclusions Our study confirms that LACV contribution to stroke volume increases along with worsening DD, as assessed in the context of (near) constant-volume four-chamber heart physiology. Thus, LACV can serve as new parameter for DD grading severity in HF patients.
Source: Clinical Research in Cardiology - June 30, 2015 Category: Cardiology Source Type: research

Blood pressure and prognosis in patients with incident heart failure: the Diet, Cancer and Health (DCH) cohort study
Conclusion We have shown for the first time that amongst a population with incident HF, higher baseline systolic, diastolic and pulse pressure levels were associated with a higher rate of adverse events. Our data support the importance for optimised BP control, as part of the holistic management of HF patients.
Source: Clinical Research in Cardiology - June 26, 2015 Category: Cardiology Source Type: research

Influence of non-cardiac comorbidities on outcome after percutaneous mitral valve repair: results from the German transcatheter mitral valve interventions (TRAMI) registry
Conclusions MitraClip device placement is feasible and safe in patients with multiple non-cardiac comorbidities resulting in a significant clinical improvement and acceptable intrahospital and 30-day event rates. Renal failure is an independent predictor of outcome.
Source: Clinical Research in Cardiology - May 29, 2015 Category: Cardiology Source Type: research