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Source: Neurological Sciences

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Total 431 results found since Jan 2013.

The role of the Sapienza GLObal Bedside Evaluation of Swallowing after Stroke (GLOBE-3S) in the prevention of stroke-associated pneumonia (SAP)
ConclusionsThe new GLOBE-3S screening test can reduce the risk of SAP compared to WST.
Source: Neurological Sciences - July 16, 2021 Category: Neurology Source Type: research

The European Portuguese version of the Oxford Cognitive Screening (OCS-Pt): a screening test for acute stroke patients
AbstractIn Portugal, there is no gold standard test to assess acute stroke patients in the hospital context. However, cognitive deficits are common after a stroke episode and are followed by a negative impact on a patient ’s quality of life and rehabilitation. Here, we first aimed to adapt the Oxford Cognitive Screening to European Portuguese speakers (OCS-Pt), develop normative data cut-offs, and report the psychometric properties of the OCS-Pt. The second aim was to test the incidence of impairments in acute stro ke patients. We tested 137 healthy participants aged between 25 and 92 years old, and we report normative ...
Source: Neurological Sciences - January 13, 2022 Category: Neurology Source Type: research

Multiple chronic lacunes predicting early neurological deterioration and long-term functional outcomes according to TOAST classification in acute ischemic stroke
ConclusionsThe presence of MCL was an independent predictive factor for END as well as long-term poor functional outcome in acute ischemic stroke patients. These associations were only observed in patients with LAA, not in those with SVO, CE, or other etiology.
Source: Neurological Sciences - October 18, 2022 Category: Neurology Source Type: research

The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature
Abstract Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke. Some studies have found that UA is a predictor for stroke by mechanisms involved in development. There are some controversies about whether it is an independent effect of UA or an epiphenomenon. UA has been widely concerned for its neuroprotective effect as an antioxidant. In some experimental models of acute ischemic stroke, UA levels are associated with better functional recovery because of its synergistic effect with alteplase. In this re...
Source: Neurological Sciences - March 13, 2015 Category: Neurology Source Type: research

Hospital-based register of stroke in the Molise Region: focus on main subtypes of stroke. Years 2009–2013
This study is part of the "Rete Molisana dell’Ictus Cerebrale (REMOLIC)” study, a population-based Cerebrovascular Registry in Molise, from 2009 to 2013, with a cold pursuit approach. The crude annual incidence rates for total stroke per 100,000 inhabitants, notified by hospital discharge records, were 198 for 2009, 185 for 2010, 169 for 2011, and 176 for both 2012 and 2013. There was a significant decrease in risk in the years 2011–2013 [RR2011 vs. 2009: 0.85 (0.76–0.98), RR2012 vs. 2009: 0.89 (0.79–0.99), RR2013 vs. 2009: 0.89 (0.79–0.99)] as compared with 2009. For the year 2010, after adjustment to the...
Source: Neurological Sciences - September 10, 2015 Category: Neurology Source Type: research

Copy number variations and stroke
Abstract Stroke is the third leading cause of death worldwide after heart disease and all forms of cancers. Monogenic disorders, genetic, and environmental risk factors contribute to damaging cerebral blood vessels and, consequently, cause stroke. Developments in genomic research led to the discovery of numerous copy number variants (CNVs) that have been recently identified as a new tool for understanding the genetic basis of many diseases. This review discusses the current understanding of the types of stroke, the existing knowledge on the involvement of specific CNVs in stroke as well as the limitations of the m...
Source: Neurological Sciences - July 7, 2016 Category: Neurology Source Type: research

Pathogenic mechanisms following ischemic stroke
AbstractStroke is the second most common cause of death and the leading cause of disability worldwide. Brain injury following stroke results from a complex series of pathophysiological events including excitotoxicity, oxidative and nitrative stress, inflammation, and apoptosis. Moreover, there is a mechanistic link between brain ischemia, innate and adaptive immune cells, intracranial atherosclerosis, and also the gut microbiota in modifying the cerebral responses to ischemic insult. There are very few treatments for stroke injuries, partly owing to an incomplete understanding of the diverse cellular and molecular changes ...
Source: Neurological Sciences - April 17, 2017 Category: Neurology Source Type: research

Intravenous thrombolysis in SLE-related stroke: a case report and literature review
AbstractPatients with systemic lupus erythematosus (SLE) bear an increased risk of ischemic stroke. However, evidences for treating acute stroke due to artery thrombosis in SLE patients are extremely limited. A 45-year-old woman experienced sudden left hemiplegia. She was transported to the emergency department of our hospital 2  hours after the initial symptom. According to the medical records, the patient was diagnosed with SLE at the age of 28. CT scanned 150 min after the initial symptom showed no evidence of acute changes or hemorrhage. Magnetic resonance angiography (MRA) revealed occlusion of the right proximal mi...
Source: Neurological Sciences - November 7, 2017 Category: Neurology Source Type: research

The organisation of the acute ischemic stroke management: key notes of the Italian Neurological Society and of the Italian Stroke Organization
AbstractThe main aim of acute ischemic stroke treatment is the as much possible prompt, safe and effective arterial recanalisation, in order to restore reperfusion into the ischemic brain area. The procedures obtaining this result are rapidly evolving and in the last years, we observed new evidences that affirmed the therapeutical benefit of the concomitant treatment using endovenous thrombolysis and mechanical thrombectomy in selected patients with ischemic stroke. However, all treatments are time-sensitive and the main limitation for their application is represented by the time. For this reason, the optimisation of the a...
Source: Neurological Sciences - November 27, 2017 Category: Neurology Source Type: research

The global burden of cerebral small vessel disease related to neurological deficit severity and clinical outcomes of acute ischemic stroke after IV rt-PA treatment
ConclusionsThe global burden of CSVD was independently associated with neurological deficit severity and clinical outcomes of AIS after IV rt-PA treatment. The total CVSD score is a reliable predictor for poor outcomes of AIS after IV rt-PA treatment.
Source: Neurological Sciences - March 3, 2019 Category: Neurology Source Type: research

The clinical management and rehabilitation of post stroke aphasia in Italy: evidences from the literature and clinical experience
AbstractAphasia is one of the most devastating symptoms in stroke survivors and severely affects patients ’ communication, quality of life, and social interactions. Several factors are critical to the prediction of aphasia recovery, including acute stroke management and subsequent language rehabilitation. A comprehensive assessment of language skills with appropriate instruments in different phases of post stroke months and years is needed in patients, in order to monitor their language improvement and to guide speech therapies over time. Beyond spontaneous recovery, the effects of speech and language therapy in terms of...
Source: Neurological Sciences - March 20, 2019 Category: Neurology Source Type: research

Adherence to recommendations and clinical outcomes of patients hospitalized for stroke: the role of the admission ward —a real-life investigation from Italy
ConclusionsFor patients with acute ischemic and hemorrhagic stroke, admission to neuro vs. general wards is associated with better out-of-hospital healthcare and long-term adverse outcomes.
Source: Neurological Sciences - April 1, 2019 Category: Neurology Source Type: research

Utility of a scoring system for differentiating cancer-associated stroke from cryptogenic stroke in patients with cancer
ConclusionTrousseau scores simply and clearly identify CAS.
Source: Neurological Sciences - January 6, 2020 Category: Neurology Source Type: research

Neuropsychological assessment in acute stroke patients
ConclusionsMEPS can be considered a simple and highly valuable bedside battery, easy to administer, with values of sensitivity and specificity suitable to be proposed as a screening tool for patients with acute stroke.
Source: Neurological Sciences - January 8, 2020 Category: Neurology Source Type: research

The influence of statins on the risk of post-stroke epilepsy
ConclusionAdequate treatment with statins after stroke may lower the risk of PSE.
Source: Neurological Sciences - February 20, 2020 Category: Neurology Source Type: research