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Source: Neurological Sciences
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Total 431 results found since Jan 2013.
The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine
AbstractStroke is the second leading cause of death and the most common cause of adult disabilities among elderlies. It involves a complex series of mechanisms among which, excitotoxicity is of great importance. Also, miRNAs appear to play role in post-stroke excitotoxicity, and changes in their transcriptome occur right after cerebral ischemia. Recent data indicate that specific miRNAs such as miRNA-223, miRNA-181, miRNA-125a, miRNA-125b, miRNA-1000, miRNA-132 and miRNA-124a regulate glutamate neurotransmission and excitotoxicity during stroke. However, limitations such as poor in vivo stability, side effects and inapprop...
Source: Neurological Sciences - October 17, 2016 Category: Neurology Source Type: research
Active music therapy approach for stroke patients in the post-acute rehabilitation
AbstractGuidelines in stroke rehabilitation recommend the use of a multidisciplinary approach. Different approaches and techniques with music are used in the stroke rehabilitation to improve motor and cognitive functions but also psychological outcomes. In this randomized controlled pilot trial, relational active music therapy approaches were tested in the post-acute phase of disease. Thirty-eight hospitalized patients with ischemic and hemorrhagic stroke were recruited and allocated in two groups. The experimental group underwent the standard of care (physiotherapy and occupational therapy daily sessions) and relational a...
Source: Neurological Sciences - January 29, 2017 Category: Neurology Source Type: research
Increased infections with β-blocker use in ischemic stroke, a β 2 -receptor mediated process?
This study adds to this literature using propensity score matching to limit confounding and by examining the effects of selective and non-selective β-blockers. Prospective data from acute ischemic stroke admissions at a single center f rom July 2010–June 2015 were analyzed. Outcomes included infection (urinary tract infection [UTI], pneumonia, or bacteremia), discharge modified Rankin Score (mRS), and in-hospital death. Any selective and non-selective β-blocker use during the first 3 days of admission were investigated with pr opensity score matching. A sensitivity analysis was also performed. This study included 1431...
Source: Neurological Sciences - March 2, 2017 Category: Neurology Source Type: research
Effects of robot-assisted upper limb rehabilitation in stroke patients: a systematic review with meta-analysis
AbstractTechnology-supported training is emerging as a solution to support therapists in their efforts providing high-intensity, repetitive, and task-specific treatment, in order to enhance the recovery process. The aim of this review is to assess the effectiveness of different robotic devices (end-effector and exoskeleton robots) in comparison with any other type of intervention. Furthermore, we aim to assess whether or not better improvements are obtained in the sub-acute phase after stroke onset than in the chronic phase. A research was conducted in the electronic bibliographic databases Cochrane, MEDLINE, and EMBASE. A...
Source: Neurological Sciences - May 24, 2017 Category: Neurology Source Type: research
The effect of different ankle and knee supports on balance in early ambulation of post-stroke hemiplegic patients
AbstractThe purpose of this study was to compare the effects of different ankle and knee supports on balance in early ambulation of post-stroke hemiplegic patients. This is a randomized experimental study. The study sample included 20 hemiplegic patients who were able to stand with support and who had been diagnosed with a cerebrovascular accident within the last month. A knee immobilization brace (KIB) was first placed on each individual (first application), followed by placement of knee immobilizer brace and Foot Lifter Orthosis ® (FLO) (second application), and lastly, placement of KIB and rigid taping (RT) (third appl...
Source: Neurological Sciences - July 19, 2017 Category: Neurology Source Type: research
Incidence of orolingual angioedema after intravenous thrombolysis for stroke
DiscussionThe incidence of orolingual angioedema was very low in our series. Although OA is usually mild, anaphylactoid reactions may rarely occur, because of the variable degree of activation of the complement system and kinin cascade caused by alteplase. In such instances, admission to neurointensive care may be required. Specific bradykinin antagonists or drugs that target the kallikrein-kinin system are beginning to be used in the more severe cases. Thus, doctors and nurses caring for acute stroke patients need to be able to recognize and treat this complication.
Source: Neurological Sciences - August 6, 2018 Category: Neurology Source Type: research
Predicting cerebral edema in ischemic stroke patients
ConclusionsIn ischemic stroke patients, six variables obtained during the first 24 h of hospitalization were predictive of subsequent cerebral edema development.
Source: Neurological Sciences - January 19, 2019 Category: Neurology Source Type: research
Cortical and spinal excitability changes after repetitive transcranial magnetic stimulation combined to physiotherapy in stroke spastic patients
ConclusionOne-hertz rTMS associated with PT increased the unaffected hemisphere excitability, decreased spinal excitability, and reduced post-stroke ULS.
Source: Neurological Sciences - March 8, 2019 Category: Neurology Source Type: research
Convexal subarachnoid hemorrhage and acute ischemic stroke: a border zone matter?
ConclusionsWe proposed the embolism or hemodynamic changes of the border zone arterioles as a unifying pathogenetic hypothesis of coexisting c-SAH and AIS.
Source: Neurological Sciences - April 1, 2019 Category: Neurology Source Type: research
The inter-rater reliability of the Italian version of Aphasia Rapid Test (ART) for acute ischemic stroke
ConclusionsThis study showed that the cross-cultural adaptation of the French version of the ART was successful in an Italian-speaking population.
Source: Neurological Sciences - September 14, 2019 Category: Neurology Source Type: research
Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases
ConclusionsWe demonstrate that recovery of AIS was unfavourably associated with variants of BDNF and CYP2C19 genes whilst recovery of ICH was unfavourably associated withAPOE4 gene.
Source: Neurological Sciences - November 11, 2019 Category: Neurology Source Type: research
The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke
ConclusionsThe novel CASUS can better reflect the level of cerebral reperfusion in patients with ischemic stroke and can better predict the occurrence of cardiovascular and cerebrovascular diseases.
Source: Neurological Sciences - January 2, 2020 Category: Neurology Source Type: research
Why we fail: mechanisms and co-factors of unsuccessful thrombectomy in acute ischemic stroke
ConclusionIn 20% of failing MT, thrombus cannot be reached/passed. Direct carotid puncture or surgical arterial access could be considered in these cases.In 80% of failing interventions, thrombus can be passed with the device, but the occluded vessel cannot be recanalized. Rescue techniques can be an option. Development of new devices and techniques is necessary to improve recanalization rates. Assessment of pre-existing illness could sensitize for occurring complications.
Source: Neurological Sciences - January 22, 2020 Category: Neurology Source Type: research
Transcranial direct current stimulation improves the swallowing function in patients with cricopharyngeal muscle dysfunction following a brainstem stroke
ConclusionThe bihemispheric anodal tDCS combined with simultaneous catheter balloon dilatation and conventional swallowing therapy effectively improves the swallowing function in patients with CPD caused by a brainstem stroke. tDCS may be an effective adjuvant therapy in CPD rehabilitation.
Source: Neurological Sciences - February 24, 2020 Category: Neurology Source Type: research
Clinical features of fallers among inpatient subacute stroke: an observational cohort study
ConclusionsThe severity of stroke may directly increase the risk of fall, and also indirectly, lengthening the hospitalization. Our study seems to suggest that patients with BI scores of between 21 and 30 on admission are more prone to fall in the first period of hospitalization, whereas in the second month, those with scores of between 11 and 20 on admission have a higher risk of falls. In the third month, patients with BI scores below 10 on admission are more susceptible to falls.
Source: Neurological Sciences - April 6, 2020 Category: Neurology Source Type: research
