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Source: Am J Physiol Renal P...

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Total 19 results found since Jan 2013.

Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
Abstract Non-traditional work schedules, such as shift work, have been associated with numerous health issues including cardiovascular and metabolic disease. These work schedules can chronically misalign environmental timing cues with internal circadian clock systems in the brain and in peripheral organs, leading to dysfunction of those systems and their associated biological processes. Environmental circadian disruption in the kidney may be an important factor in the increased incidence of hypertension and adverse health outcomes in human shift workers. The relationship between renal rhythmicity and injury resili...
Source: Am J Physiol Renal P... - December 28, 2020 Category: Urology & Nephrology Authors: Hill AM, Crislip GR, Stowie A, Ellis I, Ramsey A, Castanon-Cervantes O, Gumz ML, Davidson AJ Tags: Am J Physiol Renal Physiol Source Type: research

The Renal Molecular Clock: Broken by Aging and Restored by Exercise.
Abstract The mammalian circadian clock governs physiological, endocrine, and metabolic responses coordinated in a 24h rhythmic pattern by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. The SCN also dictates circadian rhythms in peripheral tissues like the kidney. The kidney has several important physiological functions including removing waste and filtering the blood, regulation of: fluid volume, blood osmolarity, blood pressure and calcium metabolism, all of which are under tight control of the molecular/circadian clock. Normal aging has a profound influence on both renal function, central and pe...
Source: Am J Physiol Renal P... - August 27, 2019 Category: Urology & Nephrology Authors: Schmitt EE, Johnson EC, Yusifova M, Bruns DR Tags: Am J Physiol Renal Physiol Source Type: research

Loss of reticulocalbin 2 lowers blood pressure and restrains angiotensin II-induced hypertension in vivo.
Abstract Hypertension affects over one billion people worldwide and increases risk for heart failure, stroke and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases. Rcn2, encoding reticulocalbin 2, is a candidate gene for atherosclerosis we previously demonstrated in mice. Here we identified Rcn2 as a novel regulator of blood pressure in mice. Rcn2 was dramatically upregulated in arteries undergoing structural remodeling. Deletion of Rcn2 lowered basal blood pressure and attenuated angiotensin II-induced hypertension in C...
Source: Am J Physiol Renal P... - April 2, 2019 Category: Urology & Nephrology Authors: Li J, Cechova S, Wang L, Isakson BE, Le T, Shi W Tags: Am J Physiol Renal Physiol Source Type: research

Exercising in a hot environment with muscle damage: effects on acute kidney injury biomarkers and kidney function.
Abstract Unaccustomed strenuous physical exertion in hot environments can result in heat stroke and acute kidney injury (AKI). Both exercise-induced muscle damage and AKI are associated with the release of interleukin-6 but whether muscle damage causes AKI in the heat is unknown. We hypothesized that muscle damaging exercise, prior to exercise in the heat would increase kidney stress. Ten healthy, euhydrated males underwent a randomized, crossover trial involving both a 60 minute downhill muscle-damaging run (EIMD), and an exercise intensity-matched non-muscle damaging flat run (CON), in random order separated by ...
Source: Am J Physiol Renal P... - July 3, 2013 Category: Urology & Nephrology Authors: Junglee NA, Di Felice U, Dolci A, Fortes MB, Jibani MM, Lemmey AB, Walsh NP, Macdonald JH Tags: Am J Physiol Renal Physiol Source Type: research