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Source: Am J Physiol Renal P...
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Total 19 results found since Jan 2013.
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the Stroke-Prone Spontaneously Hypertensive Rat
Am J Physiol Renal Physiol. 2023 Jul 13. doi: 10.1152/ajprenal.00058.2023. Online ahead of print.ABSTRACTMost SHR lines are resistant to hypertensive renal disease. However, the SHR-A3 line (stroke-prone SHR or SHRSP) experiences end organ injury (EOI) and provides a model that can be used to uncover genetic causation. In the present study we have generated a congenic line in which three distinct disease loci in SHR-A3 are concurrently replaced with the homologous loci from an injury-resistant SHR line (SHR-B2). Verification that all three loci were homozygously replaced in this triple congenic line (SHR-A3(Trip B2)) while...
Source: Am J Physiol Renal P... - July 13, 2023 Category: Urology & Nephrology Authors: Isha S Dhande Yaming Zhu Aniket S Joshi M John Hicks Michael C Braun Peter A Doris Source Type: research
Less Sodium, More Potassium, or Both: Population-wide Strategies to Prevent Hypertension
Am J Physiol Renal Physiol. 2023 Jun 1. doi: 10.1152/ajprenal.00007.2023. Online ahead of print.ABSTRACTHypertension is among the most prevalent medical conditions globally and a major contributor to chronic kidney disease, cardiovascular disease, and death. Prevention through non-pharmacologic, population-level interventions is critically needed to halt this worldwide epidemic. However, there are ongoing debates as to where public policy efforts should focus. Recently the Salt Substitute and Stroke Study demonstrated the efficacy of substituting table salt with potassium salt to reduce the risk of stroke, major cardiovasc...
Source: Am J Physiol Renal P... - June 1, 2023 Category: Urology & Nephrology Authors: Voravech Nissaisorakarn George Ormseth William Earle Martha Catalina Morales-Alvarez Swapnil Hiremath Stephen P Juraschek Source Type: research
