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Source: Neurology
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Total 3153 results found since Jan 2013.
Preconditioned M2 microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats (P1.264)
Conclusions:Intravascular administration of M2 microglia preconditioned by OGD might be a novel therapeutic strategy against ischemic stroke.Disclosure: Dr. Kanazawa has nothing to disclose. Dr. Miura has nothing to disclose. Dr. Toriyabe has nothing to disclose. Dr. Koyama has nothing to disclose. Dr. Hatakeyama has nothing to disclose. Dr. Ishikawa has nothing to disclose. Dr. Nakajima has nothing to disclose. Dr. Onodera has nothing to disclose. Dr. Nishizawa has nothing to disclose. Dr. Shimohata has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kanazawa, M., Miura, M., Toriyabe, M., Koyama, M., Hatakeyama, M., Ishikawa, M., Nakajima, T., Onodera, O., Nishizawa, M., Shimohata, T. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Orosomucoid-1 Protein Dynamics Following Ischemic Stroke in Humans and Mice (P1.265)
Conclusions:ORM-1 is a sexually dimorphic protein involved in the early (<24 hour) response to ischemic stroke. This research demonstrates that sex differences exist in post-stroke ORM-1 protein dynamics, and serves as an initial step in determining the mechanism of ORM-1 in the ischemic stroke response and its potential as a future therapeutic target for both sexes.Study Supported by:NIH Grant 5 R01 NS055215 09, and Hartford Hospital, Hartford, CT.Additional thanks to Sharon DiMauro, Lori Capozzi, and to the Scientific Research Committee at the University of Connecticut School of Medicine.Disclosure: Dr. Mistry has not...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mistry, H., Levy, M., Roy-OReilly, M., McCullough, L. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Diffusion Tensor Imaging of Corticospinal Tract Recovery after Intra-arterial Mesenchymal Stem Cell Infusion in a Canine Stroke Model (P1.266)
Conclusions:Serial DTI-DTT imaging after IA MSCs therapy in large animal stroke model appears to have a trend towards higher change in FA. These findings could support further development of DTI-DTT biomarkers to measure neurologic recovery in experimental models as well as early clinical trials of novel stroke therapies.Disclosure: Dr. Guada has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Saigal has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Medtronic and Guidepoint as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Guada, L., Pattany, P., Ramdas, K., Atchaneeyasakul, K., Saigal, G., Yavagal, D. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Development and Feasibility of a Canine Endovascular Reversible Middle Cerebral Artery Occlusion Stroke Model: a Novel anterior circulation approach (P1.267)
Conclusions:Here we report the successful development of an endovascular reversible MCAo model in the canine by an anterior circulation approach. A learning curve is seen in the successful implementation of this model, as shown by our results.Disclosure: Dr. Guada has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Watanabe has nothing to disclose. Dr. Sidani has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Medtronic and Guidepoint as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Guada, L., Ramdas, K., Atchaneeyasakul, K., Watanabe, M., Sidani, C., Yavagal, D. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Analysis of Run Sheets of EMS Serving a Metropolitan Comprehensive Stroke Center (P1.268)
Conclusions:Patients with acute stroke transported by EMS have better quality metrics and higher chance of receiving acute treatment. EMS documented assessment allows for the diagnosis or stroke in general but cannot identify LVO because the assessment of cortical signs is very limited.Disclosure: Dr. Hussein has nothing to disclose. Dr. Kashyap has nothing to disclose. Dr. Erickson has nothing to disclose. Dr. Forsberg has nothing to disclose. Dr. Burnett has nothing to disclose. Dr. Stanfield has nothing to disclose. Dr. Wewerka has nothing to disclose. Dr. Terwilliger has nothing to disclose. Dr. Hanson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hussein, H., Kashyap, B., Erickson, L., Forsberg, A., Burnett, A., Stanfield, S., Wewerka, S., Terwilliger, A., Hanson, L. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Early Experience on Intravenous Tissue Plasminogen Activator Delivery in Mobile Stroke Unit Patients with Stroke Mimics (P1.269)
Conclusions:In our early experience with MSU, treatment of stroke mimics occurred without IV-tPA related complications. This does not appear to be due to rushed decision making.Disclosure: Dr. Sheikhi has nothing to disclose. Dr. Winners has nothing to disclose. Dr. George has nothing to disclose. Dr. Russman has received personal compensation for activities with Genentech and Bristol-Myers Squibb as a scientific advisory board member. Dr. Khawaja has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Hussain has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Sheikhi, L., Winners, S., George, P., Russman, A., Khawaja, Z., Uchino, K., Hussain, M. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Patient characteristics affecting stroke recognition by emergency medical service providers in Kings County Hospital Center (P1.270)
Conclusions:More than half of actual stroke patients were missed in the field in our study. Our study identifies potential patient characteristics affecting stroke recognition by EMS.Disclosure: Dr. Cuascut Lassus has nothing to disclose. Dr. Law has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lassus, F. C., Law, S. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Walk-in versus ems-prenotified stroke codes-time targets in a comprehensive stroke center (p1.271)
Conclusions:Walk-in strokes had significant delay in LKW to arrival, highlighting the need for community education in recognizing symptoms of stroke. People with larger strokes(higher NIHSS) tend to present via EMS. Significant delays in door to CT and stroke-code in walk-in strokes, demonstrates need for early stroke symptom recognition in the ER. EMS education and pre-notification improves likelihood of tPA administration.Disclosure: Dr. Kaur has nothing to disclose. Dr. Gudlavalleti has nothing to disclose. Dr. Schleier has nothing to disclose. Dr. Vallelunga has nothing to disclose. Dr. Onyan has nothing to disclose. D...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kaur, G., Gudlavalleti, A., Schleier, J., Vallelunga, M., Onyan, J., Latorre, J. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Evaluation of NIHSS-Onset to Groin Time (OGT) and Prehospital Acute Stroke Severity Scale (PASS)-OGT scores in prediction of outcomes after Endovascular Treatment in Acute Ischemic Stroke patients: A Retrospective Single-Center Study (P1.272)
Conclusions:Our study indicates NIHSS–OGT and PASS-OGT scores have a linear relationship with discharge mRS and can reliably predict early clinical outcomes after ET. Further confirmation with randomized control trials is needed.Disclosure: Dr. Niazi has nothing to disclose. Dr. E-Ghanmh has nothing to disclose. Dr. Reichwein has nothing to disclose. Dr. Cockroft has nothing to disclose. Dr. Ermak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Niazi, M., El-Ghanem, M., Reichwein, R., Cockroft, K., Ermak, D. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Differences in the last known well time between neurology, ED providers and EMS providers. (P1.273)
Conclusions:Our study suggests there is no good agreement between the ED and neurology LKW times. The addition of a short standardized questionnaire may help further improve LKW times.Disclosure: Dr. Doyle has nothing to disclose. Dr. Horton has nothing to disclose. Dr. Magadan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Doyle, A., Horton, L., Magadan, A. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Evaluation and Validation of Prehospital Acute Stroke Scale to Predict Large Vessel Occlusion in Patients with Proven Large Vessel Occlusion- Single Center study in US (P1.274)
Conclusions:The PASS tool is simple, quick, and easy to perform and has high sensitivity in AIS patients with LVO. To assess its value and efficacy in real time it should be implemented into EMS systems and be performed in the pre-hospital setting.Disclosure: Dr. E-Ghanmh has nothing to disclose. Dr. Niazi has nothing to disclose. Dr. Reichwein has nothing to disclose. Dr. Ermak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: El-Ghanem, M., Niazi, M., Reichwein, R., Ermak, D. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Lytic therapy and mechanical thrombecomty over tele-stroke, a comprehensive stroke center experience (P1.275)
Conclusions:Our study shows that our Tele stroke program had evolved over time to involve more sites throughout the state of South Carolina. Post IV tPA sICH was within the expected range.Disclosure: Dr. Al Kasab has nothing to disclose. Dr. Debenham has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Holmstedt has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kasab, S. A., Debenham, E., Jones, D. J., Holmstedt, C. A. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Safety and Efficacy of Thrombolysis in Telestroke for the Extended Time Window (P1.276)
Conclusions:There was no significant difference in sICH or mRS for patients who received thrombolysis through telestroke before 3 hours compared to those that received it in 3 to 4.5 hours. This data suggests that it is safe and efficacious to give IV tPA with telemedicine from 3 to 4.5 hours.Disclosure: Dr. Steinberg has nothing to disclose. Dr. Kenmuir has nothing to disclose. Dr. Jovin has received personal compensation for activities with Codman and Neuravi as a consultant. Dr. Jovin has received compensation for serving on Anaconda, Silk Road, Blockade Medical. Dr. Wechsler has received personal compensation for activ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Steinberg, A., Kenmuir, C., Jovin, T., Wechsler, L., Jadhav, A. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
Door to Page Time to Initiate a Telemedicine Consult Varies Among Spoke Hospitals for Acute Stroke (P1.277)
Conclusions:Bed capacity, pre-notification, location in a MUA, and in-house neurology availability are associated with prolonged DTP. Further investigation is needed to understand why these factors affect DTP. While retrospective in nature, our study confirms the utility of pre-notification for spoke hospitals. In addition, standardized acute stroke metrics over TM are needed.Disclosure: Dr. Randhawa has nothing to disclose. Dr. Jagolino has nothing to disclose. Dr. Ankrom has nothing to disclose. Dr. Bozorgui has nothing to disclose. Dr. Bambhoroliya has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Cossey ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Randhawa, J., Jagolino, A., Ankrom, C., Bozorgui, S., Bambhoroliya, A., Vahidy, F., Cossey, T., Savitz, S., Wu, T.-C. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
The Experience of Spoke Hospitals in an Academic Telestroke Network (P1.278)
Conclusions:Within this single hub-spoke telestroke system in the Northeast, we found that spoke hospitals perceive the advantages of telestroke to be in enabling improved rates and efficiency of tPA administration. Barriers to use were most often related to technological challenges rather than concerns about patient care or patients’ perceptions. Future work should further explore how to better meet the needs of spoke hospitals in caring for stroke patients.Disclosure: Dr. Gadhia has nothing to disclose. Dr. Schwamm has received personal compensation for activities with Lundbeck, LifeImage, and Medtronic as a consul...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Gadhia, R., Schwamm, L., Viswanathan, A., Whitney, C., Moreno, A., Zachrison, K. S. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research
