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Total 3153 results found since Jan 2013.

Validating and comparing stroke prognosis scales
Conclusions: Our comparative analyses confirm differences in the prognostic accuracy of stroke scales. However, even the best performing scale had prognostic accuracy that may not be sufficient as a basis for clinical decision-making.
Source: Neurology - September 4, 2017 Category: Neurology Authors: Quinn, T. J., Singh, S., Lees, K. R., Bath, P. M., Myint, P. K., On behalf of the VISTA Collaborators Tags: Outcome research, Prognosis, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

White matter hyperintensity reduction and outcomes after minor stroke
Conclusions: Some WMH may regress after minor stroke, with potentially better clinical and brain tissue outcomes. The role of risk factor control requires verification. Interstitial fluid alterations may account for some WMH reversibility, offering potential intervention targets.
Source: Neurology - September 4, 2017 Category: Neurology Authors: Wardlaw, J. M., Chappell, F. M., Valdes Hernandez, M. d. C., Makin, S. D. J., Staals, J., Shuler, K., Thrippleton, M. J., Armitage, P. A., Munoz-Maniega, S., Heye, A. K., Sakka, E., Dennis, M. S. Tags: MRI, Vascular dementia, Infarction ARTICLE Source Type: research

Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage
Conclusion: Unlike in ischemic stroke, there was no evidence that patient sex modified the effect of age on 90-day outcomes after ICH in a large multiracial/ethnic population. Future studies should evaluate biological reasons for these differences between stroke subtypes. Clinicaltrials.gov identifier: NCT01202864.
Source: Neurology - September 4, 2017 Category: Neurology Authors: James, M. L., Langefeld, C. D., Sekar, P., Moomaw, C. J., Elkind, M. S. V., Worrall, B. B., Sheth, K. N., Martini, S. R., Osborne, J., Woo, D., On behalf of the ERICH Investigators Tags: Outcome research, Clinical trials Observational study (Cohort, Case control), Intracerebral hemorrhage ARTICLE Source Type: research

Intra-arterial milrinone may differentiate fulminant RCVS from vasculitis
A 39-year-old woman taking a monoamine oxidase inhibitor presented with a 1-week history of severe non-thunderclap headache and visual field deficits. Brain CT showed infarcts in both parietal lobes, with narrowing of intracranial vessels on CT angiogram (figure 1), suggesting either vasculitis or reversible cerebral vasoconstriction syndrome (RCVS). Despite treatment with both methylprednisolone and nimodipine, she experienced progressive aphasia and right leg weakness. She underwent an urgent cerebral angiogram (figure 2), during which intra-arterial milrinone reversed both the vasoconstriction and its symptoms, thereby ...
Source: Neurology - September 4, 2017 Category: Neurology Authors: Laneuville, M., Ding, J., Shamy, M., Lum, C., Dowlatshahi, D. Tags: All Headache, Other cerebrovascular disease/ Stroke NEUROIMAGES Source Type: research

Sudden unexpected death in epilepsy patients is often misdiagnosed as sudden cardiac death
Sudden unexpected death in epilepsy patients (SUDEP) represents the second main neurologic cause of years of potential life lost, following stroke, with a cumulative lifetime risk reaching 8% for childhood-onset epilepsy.1 In light of these worrying figures, the American Academy of Neurology (AAN) has recently published practice guidelines on the risk of SUDEP. These guidelines emphasize the "considerable uncertainty"of SUDEP incidence in adults with epilepsy, currently estimated at 1.2/1,000 patient-years (95% CI 0.64–2.32).2 Difficulties in assessing the epidemiology of SUDEP are several, including large variation ...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Ryvlin, P., Cascino, G. D. Tags: All Epilepsy/Seizures EDITORIALS Source Type: research

Individualized risk prediction of major bleeding in secondary stroke prevention: Are we there yet?
In most patients diagnosed with a TIA or ischemic stroke, secondary stroke prevention relies on antiplatelet therapy unless anticoagulation is indicated. Aspirin has the largest evidence base and reduces the risk of early recurrent ischemic stroke without a major risk of early hemorrhagic complications.1 Because antiplatelet therapy typically continues for many years, clinicians and patients need an estimation of the annual bleeding risk to accurately assess future risk. In a meta-analysis of 25 randomized trials of antiplatelet therapy in primary or secondary prevention of cardiovascular disease, aspirin increased the abs...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lemmens, R., Al-Shahi Salman, R. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology, Infarction EDITORIALS Source Type: research

Association of parathyroid hormone with 20-year cognitive decline: The ARIC study
Conclusions: Our work does not support an independent influence of PTH on cognitive decline in this population-based cohort study.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Kim, S. M., Zhao, D., Schneider, A. L. C., Korada, S. K., Lutsey, P. L., Guallar, E., Alonso, A., Windham, B. G., Gottesman, R. F., Michos, E. D. Tags: Endocrine, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S2TOP-BLEED
Conclusions: The S2TOP-BLEED score can be used to estimate 3-year major bleeding risk in patients with a TIA or ischemic stroke who use antiplatelet agents, based on readily available characteristics. The discriminatory performance may be improved by identifying stronger predictors of major bleeding.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Hilkens, N. A., Algra, A., Diener, H.-C., Reitsma, J. B., Bath, P. M., Csiba, L., Hacke, W., Kappelle, L. J., Koudstaal, P. J., Leys, D., Mas, J.-L., Sacco, R. L., Amarenco, P., Sissani, L., Greving, J. P., For the Cerebrovascular Antiplatelet Trialists' Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Activity limitations and subjective well-being after stroke
Conclusions: Activity limitations were not associated with stroke survivors' subjective well-being after adjustment for other factors. While some predictors of well-being after stroke were identified, the determinants of well-being remained largely unexplained.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Zahuranec, D. B., Skolarus, L. E., Feng, C., Freedman, V. A., Burke, J. F. Tags: Quality of life, All Cerebrovascular disease/Stroke, All Rehabilitation ARTICLE Source Type: research

Clinical Reasoning: A 61-year-old man with conjugate gaze deviation, hemiparesis, and asymmetric reflexes
A 61-year-old man with a history of alcoholic cirrhosis was transferred from an outside hospital for spontaneous bacterial peritonitis, septic shock, and respiratory failure after intubation. The patient was initially on sedation; however, more than 48 hours after the sedative was discontinued, his mental status remained depressed and he also developed new onset of conjugate rightward gaze deviation. On neurologic examination, the patient was unresponsive to verbal stimuli and sternal rub. He could not follow any command, including closing or opening eyes and squeezing hands. He had remarkable conjugate, forced eye deviati...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lin, C.-Y., Yoo, J. Y., Doshi, A., Colman, R. Tags: MRI, Clinical neurology examination, All Cerebrovascular disease/Stroke, Critical care, Video/ EEG use in epilepsy RESIDENT AND FELLOW SECTION Source Type: research

Mystery Case: A case of fulminant encephalopathy in a 69-year-old woman
A 69-year-old right-handed woman was admitted to the medical intensive care unit for acute encephalopathy. Her medical history included sickle cell disease (hemoglobin sickle cell [HbSC]) with bone involvement (bilateral femoral head osteonecrosis) and rare sickle cell crises with joint pain and hemolytic anemia requiring red blood cell transfusions, sarcoidosis, diabetes, hypertension, and hypothyroidism. She never smoked cigarettes and never used recreational drugs or alcohol, and there was no history of recent travel. The patient's daughter reported that the patient was found unresponsive lying on the floor in the morni...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lamotte, G., Williams, C. Tags: MRI, Other cerebrovascular disease/ Stroke, Coma, Critical care, Embolism RESIDENT AND FELLOW SECTION Source Type: research

Response to pain
She is lying there behind a glass wall too covered in white: air too white, people too white crowded around her funeral chorus of ridiculous moves: her arm is raised and left to fall her eyes are opened and left to close her blood is food to a machine that turns it white, its sins forgiven. White coats, birds of prey! where have you taken her? my faith in you has vanished like a hunted animal you seek to give your prisoner the gift of pain so she would rise in screams above the whiteness of that stiffening bed. In vain! you absurd creatures! what can you hope to save in violence? A soul? not possible. The body alone? not p...
Source: Neurology - August 21, 2017 Category: Neurology Authors: Parvan, A. Tags: All Cerebrovascular disease/Stroke REFLECTIONS: NEUROLOGY AND THE HUMANITIES Source Type: research

DNA methylation predicts stroke outcome better: The epigenetic clock is ticking
As a leading cause of disability worldwide, stroke renders people disabled through several mechanisms. Over half of patients have sensorimotor and cognitive deficits, one-third experience depression and social disability, and half never return to work. Our ability to predict recurrent stroke and disability poststroke remains poor despite modern medical advances.1 The uncertainty surrounding the recovery process creates critical knowledge gaps for clinicians deciding on the most appropriate care plan, and leads to substantial anxiety for patients and their families. Identification of factors that affect prognosis after stro...
Source: Neurology - August 21, 2017 Category: Neurology Authors: Wang, L., Pare, G., Rundek, T. Tags: EDITORIALS Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage
Conclusions: These data support the hypothesis that magnesium exerts a clinically meaningful influence on hemostasis in patients with ICH.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Liotta, E. M., Prabhakaran, S., Sangha, R. S., Bush, R. A., Long, A. E., Trevick, S. A., Potts, M. B., Jahromi, B. S., Kim, M., Manno, E. M., Sorond, F. A., Naidech, A. M., Maas, M. B. Tags: All Cerebrovascular disease/Stroke, Critical care, Intracerebral hemorrhage ARTICLE Source Type: research