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Total 1979 results found since Jan 2013.

Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension
Conclusions: In chronic hemiparesis, single abobotulinumtoxinA (Dysport Ipsen) administration reduced muscle tone. Repeated administration over a year was well-tolerated and improved walking speed and likelihood of achieving community ambulation. Clinicaltrial.gov identifiers: NCT01249404, NCT01251367. Classification of evidence: The double-blind phase of this study provides Class I evidence that for adults with chronic spastic hemiparesis, a single abobotulinumtoxinA injection reduces lower extremity muscle tone.
Source: Neurology - November 27, 2017 Category: Neurology Authors: Gracies, J.-M., Esquenazi, A., Brashear, A., Banach, M., Kocer, S., Jech, R., Khatkova, S., Benetin, J., Vecchio, M., McAllister, P., Ilkowski, J., Ochudlo, S., Catus, F., Grandoulier, A. S., Vilain, C., Picaut, P., On behalf of the International Abobotul Tags: Gait disorders/ataxia, Botulinum toxin, All Clinical trials ARTICLE Source Type: research

Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice
Conclusion: Low-dose aspirin is not associated with an increased risk of any type of ICB and is associated with a significantly decreased risk of SAH when used for ≥1 year.
Source: Neurology - November 27, 2017 Category: Neurology Authors: Cea Soriano, L., Gaist, D., Soriano-Gabarro, M., Bromley, S., Garcia Rodriguez, L. A. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Big data trends in stroke epidemiology in the United States: But are they good data?
Based on prior epidemiologic studies in the United States, approximately 80% of first-time strokes can be explained by modifiable risk factors such as hypertension, and therefore optimal control or elimination of known risk factors might prevent these strokes.1 Campaigns such as the American Heart Association (AHA) initiative, Life's Simple 7, have set ambitious goals for optimal cardiovascular and stroke risk factor control; in addition, a wealth of online resources are available for an increasingly health-conscious society.2 There are indeed some glimmers of hope. Efforts to prevent stroke, in large part from emphasis on...
Source: Neurology - November 6, 2017 Category: Neurology Authors: Prabhakaran, S. Tags: EDITORIALS Source Type: research

Population-based study of home-time by stroke type and correlation with modified Rankin score
Conclusions: We showed that home-time is an objective and graded indicator that is correlated with disability after stroke. It is obtainable from administrative data, applicable to different stroke types, and a valuable outcome indicator in population-based health services research.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Yu, A. Y. X., Rogers, E., Wang, M., Sajobi, T. T., Coutts, S. B., Menon, B. K., Hill, M. D., Smith, E. E. Tags: Outcome research, Medical care, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Radiographic and symptomatic brain ischemia in CEA and CAS: A systematic review and meta-analysis
Conclusions: One in 5 persons with periprocedural radiographic brain ischemia during CEA and CAS had strokes and TIAs. The stable ratio of stroke and TIA to radiographic ischemia suggests that MRI ischemia could serve as a surrogate measure of periprocedural risk.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Cho, S.-M., Deshpande, A., Pasupuleti, V., Hernandez, A. V., Uchino, K. Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Increasing prevalence of vascular risk factors in patients with stroke: A call to action
Conclusions: Despite numerous guidelines and prevention initiatives, prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS increased across the 2004–2014 period. Proportion of patients with carotid stenosis, CRF, and multiple risk factors also increased. Enhanced risk factor modification strategies and implementation of evidence-based recommendations are needed for optimal stroke prevention.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Otite, F. O., Liaw, N., Khandelwal, P., Malik, A. M., Romano, J. G., Rundek, T., Sacco, R. L., Chaturvedi, S. Tags: Stroke prevention, Embolism, Prevalence studies, Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Editors' Note
: In "Evaluating the safety of β-interferons in MS: A series of nested case-control studies," de Jong et al. found that exposure to β-interferons was associated with a 1.8-fold increased risk of stroke. Commenting on the study, Dr. Jongen shares his own prospective study on adverse events in 284 patients with multiple sclerosis treated with intramuscular interferon-β-1a: one patient died from a stroke sinus thrombosis 22 months after start of treatment.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Karam, C., Griggs, R. C. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Letter re: Evaluating the safety of {beta}-interferons in MS: A series of nested case-control studies
In a series of case-control studies of patients with multiple sclerosis (MS), de Jong et al.1 found that exposure to β-interferons was associated with a 1.8-fold increased risk of stroke. The authors rightfully state that stroke is not well-recognized as a potential adverse event of β-interferons, referring to cases reported in 2006 and 2008.2,3
Source: Neurology - November 6, 2017 Category: Neurology Authors: Jongen, P. J. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Polycystic kidney disease and intracranial aneurysms: Some answers, but many questions remain
Unruptured intracranial aneurysms (UIA) occur in about 2%–3% of the population. Several medical conditions are associated with a UIA presence, including autosomal dominant polycystic kidney disease (ADPKD). Clinicians and patients want to know the risk of aneurysm growth, rupture, or de novo development, predictors of clinical outcomes, and the optimal initial and follow-up screening for individuals with UIA and ADPKD. Such data are unavailable. The recent American Heart Association–American Stroke Association statement on UIAs recommends that patients with familial risk and patients with conditions in which an...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Torner, J. C., Brown, R. D. Tags: EDITORIALS Source Type: research

Oral antidiabetic drugs and dementia risk: Does treatment matter?
As the population ages, dementia grows as a public health problem. The rising life expectancy and the aging of the so-called baby boomer cohort translate to a substantial number of people reaching ages of high risk for age-related conditions like dementia. As a major cause of disability and dependency in elderly people, dementia puts social and economic burden on patients and their families and affects health care systems worldwide. In the absence of a cure, primary prevention will have the largest effect on the reduction of dementia occurrence.1 Thus, public health research should focus on the identification of modifiable...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Fink, A., Haenisch, B. Tags: All Cognitive Disorders/Dementia, All epidemiology EDITORIALS Source Type: research

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population
Conclusions: Subarachnoid hemorrhage occurs at younger age and from smaller IAs in patients with ADPKD and risk for de novo IAs is higher than in the general Eastern Finnish population. ADPKD should be considered as an indicator for long-term angiographic follow-up in patients with diagnosed IAs.
Source: Neurology - October 30, 2017 Category: Neurology Authors: Nurmonen, H. J., Huttunen, T., Huttunen, J., Kurki, M. I., Helin, K., Koivisto, T., von und zu Fraunberg, M., Jääskeläinen, J. E., Lindgren, A. E. Tags: Stroke in young adults, Cohort studies, Subarachnoid hemorrhage, All Genetics ARTICLE Source Type: research

Thrombolysis in acute ischemic stroke in patients with dementia: A Swedish registry study
Conclusions: Younger patients with dementia and AIS are less likely to receive IVT. Among patients receiving thrombolysis, there are no differences in sICH or death, although patients with dementia have worse accommodation and functional outcomes at 3 months.
Source: Neurology - October 30, 2017 Category: Neurology Authors: Zupanic, E., von Euler, M., Kareholt, I., Contreras Escamez, B., Fastbom, J., Norrving, B., Religa, D., Kramberger, M. G., Winblad, B., Johnell, K., Eriksdotter, M., Garcia-Ptacek, S. Tags: Prognosis, All Cognitive Disorders/Dementia, Cohort studies, Infarction ARTICLE Source Type: research

Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease
Conclusions: This longitudinal prospective study provides evidence that change in MRI measures including DTI, over time durations during which cognitive change is not detectable, predicts cognitive decline and progression to dementia. It supports the use of MRI measures, including DTI, as useful surrogate biomarkers to monitor disease and assess therapeutic interventions.
Source: Neurology - October 30, 2017 Category: Neurology Authors: Zeestraten, E. A., Lawrence, A. J., Lambert, C., Benjamin, P., Brookes, R. L., Mackinnon, A. D., Morris, R. G., Barrick, T. R., Markus, H. S. Tags: MRI, DWI, Other cerebrovascular disease/ Stroke, All Cognitive Disorders/Dementia, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores
Conclusions: Persons with Parkinson disease meeting modified criteria for metabolic syndrome experienced a greater increase in total UPDRS scores over time, mainly as a result of increases in motor scores, compared to those who did not. Further studies are needed to confirm this finding. ClinicalTrials.gov identifier: NCT00449865.
Source: Neurology - October 23, 2017 Category: Neurology Authors: Leehey, M., Luo, S., Sharma, S., Wills, A.-M. A., Bainbridge, J. L., Wong, P. S., Simon, D. K., Schneider, J., Zhang, Y., Perez, A., Dhall, R., Christine, C. W., Singer, C., Cambi, F., Boyd, J. T. Tags: All Medical/Systemic disease, Endocrine, Parkinson's disease/Parkinsonism ARTICLE Source Type: research

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls
Conclusions: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.
Source: Neurology - October 23, 2017 Category: Neurology Authors: Rannikmäe, K., Sivakumaran, V., Millar, H., Malik, R., Anderson, C. D., Chong, M., Dave, T., Falcone, G. J., Fernandez-Cadenas, I., Jimenez-Conde, J., Lindgren, A., Montaner, J., O'Donnell, M., Pare, G., Radmanesh, F., Rost, N. S., Slowik, A., So& Tags: All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage, All Genetics, Association studies in genetics ARTICLE Source Type: research