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Temporal Trends in Stroke Incidence in the Young in the Framingham Study (S32.007)
Conclusions: In contrast to declining risk in older adults, the risk of incident stroke for young adults remained constant over four consecutive 10-year periods, beginning in 1968. Possible reasons for the persistently elevated risk will be explored, including genetic propensities, adverse trends in risk factor prevalence, failure to appreciate risk, and differences in stroke subtypes. Disclosure: Dr. Aparicio has nothing to disclose. Dr. Beiser has nothing to disclose. Dr. Himali has nothing to disclose. Dr. Satizabal has nothing to disclose. Dr. Pase has nothing to disclose. Dr. Romero has nothing to disclose. Dr. ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Aparicio, H. J., Beiser, A., Himali, J., Satizabal, C., Pase, M., Romero, J., Kase, C., Seshadri, S. Tags: Neuroepidemiology Source Type: research

Onset to Reperfusion Times Strongly Determine Clinical Outcome Across a Wide Range of ASPECTS Scores in Endovascular Ischemic Stroke Therapy (P6.002)
CONCLUSIONS: Patients with higher ASPECTS scores are more likely to have good clinical outcomes at all onset to reperfusion intervals. But from 2 hours on, benefit falls at a steep and even pace across all ASPECT categories, reinforcing the need to treat all patients as fast as possible.Disclosure: Dr. Kim has nothing to disclose. Dr. Goyal has nothing to disclose. Dr. Pereira-Mendes has received personal compensation for activities with Stryker. Dr. Bonafe has nothing to disclose. Dr. Gralla has nothing to disclose. Dr. Jahan has received personal compensation for activities with ev3 Inc. as a consultant. Dr. Levy has rec...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kim, J.-T., Goyal, M., Pereira-Mendes, V., Bonafe, A., Gralla, J., Jahan, R., Levy, E., Liebeskind, D., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Intra-arterial ALD401 Cell Therapy Is Associated with Reduction in Stroke Volume at 90 Days in a Subset of the RECOVER-Stroke Trial (P6.004)
Conclusions: In this exploratory analysis from one center in the multi-center RECOVER-Stroke trial, intra-arterial stem cell injection with ALD-401 was associated with significant reduction in stroke volume at 90 days post therapy compared to sham procedure in subacute ischemic stroke patients.Disclosure: Dr. Atchaneeyasakul has nothing to disclose. Dr. Dharmadhikari has nothing to disclose. Dr. Sidani has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Delgado has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Da...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Atchaneeyasakul, K., Dharmadhikari, S., Sidani, C., Ramdas, K., Delgado, L., Pafford, R., Huang, D., Hinson, J., Savitz, S., Yavagal, D. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Failing a Dysphagia Screening Test after Acute Ischemic Stroke: Baseline Patient Factors and Outcomes (P6.037)
CONCLUSIONS: Patients with ischemic stroke who failed a dysphagia screening test had worse pre-admission function and more severe strokes, and developed much higher rates of complications and death than those who passed. Multivariable analyses are pending to control for stroke severity and determine the strength of these associations.Disclosure: Dr. Joundi has nothing to disclose. Dr. Martino has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Fang has nothing to disclose. Dr. Giannakeas has nothing to disclose. Dr. Kapral has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Joundi, R., Martino, R., Saposnik, G., Fang, J., Giannakeas, V., Kapral, M. Tags: In-Hospital Stroke and Stroke Complications Source Type: research

Onset to Reperfusion Times Strongly Determine Clinical Outcome Across a Wide Range of ASPECTS Scores in Endovascular Ischemic Stroke Therapy (I6.0010)
CONCLUSIONS: Patients with higher ASPECTS scores are more likely to have good clinical outcomes at all onset to reperfusion intervals. But from 2 hours on, benefit falls at a steep and even pace across all ASPECT categories, reinforcing the need to treat all patients as fast as possible.Disclosure: Dr. Kim has nothing to disclose. Dr. Goyal has nothing to disclose. Dr. Pereira-Mendes has received personal compensation for activities with Stryker. Dr. Bonafe has nothing to disclose. Dr. Gralla has nothing to disclose. Dr. Jahan has received personal compensation for activities with ev3 Inc. as a consultant. Dr. Levy has rec...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kim, J.-T., Goyal, M., Pereira-Mendes, V., Bonafe, A., Gralla, J., Jahan, R., Levy, E., Liebeskind, D., Saver, J. Tags: Future Directions and Challenges in Stroke Team Action Therapy (STAT) Poster Presentations Source Type: research

90 Day Outcome after Reperfusion Therapy of Stroke Patients with Baseline Disability: Unique Observations from Patients Treated on the Mobile Stroke Unit (P6.052)
Conclusion: In comparison to previously published data our analysis shows unfavorable outcome in the majority of patients with baseline disability who received thrombolytic therapy. The small sample size is a limitation to this analysis, and further studies are needed to assess if this subpopulation should be included in clinical trials assessing new therapies or modalities to deliver them.Disclosure: Dr. almaghrabi has nothing to disclose. Dr. Sarraj has nothing to disclose. Dr. Bowry has nothing to disclose. Dr. Parker has nothing to disclose. Dr. Yamal has nothing to disclose. Dr. Grotta has received personal compensati...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Almaghrabi, T., Sarraj, A., Bowry, R., Parker, S., Yamal, J.-M., Grotta, J. Tags: Prehospital Stroke Care and Uses of NIHSS Source Type: research

Use of ICH Score to Predict Disposition of Patients with Intraparenchymal Hemorrhage (P6.063)
Conclusion ICH score of 3 predicts either dead or severely disabled requiring skilled nursing facility. Inpatient rehabilitation is a major disposition for patient with ICH score of 0-2.Disclosure: Dr. Singh has nothing to disclose. Dr. Dugyala has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Singh, N., Dugyala, V. Tags: Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy Source Type: research

Hemicraniectomy Versus Conservative Treatment in Large Hemispheric Ischemic Stroke Patients: A Meta-Analysis of Randomized Controlled Trials (P6.067)
Conclusions: Compared with conservative treatment, the odds of achieving a favorable outcome outcome at 6 months post-randomization is approximately 2 folds higher with hemicraniectomy in patients with large hemispheric infarctionsDisclosure: Dr. Ishfaq has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ishfaq, M., Rahman, H., Thomas, A., Qureshi, A. Tags: Cerebrovascular Disease: Miscellaneous Interventions Source Type: research

Hepatic S1P Deficiency Reduces Atheroma Formation in LDLR-/- Mice (P5.227)
Conclusion: Hepatic S1P is a physiological modulator of plasma lipid metabolism through its regulation of VLDL secretion, especially when LDLR function is compromised. Utilizing genetic models, our data demonstrate the protective effect of hepatic S1P inhibition for reducing atheroma formation. Thus, S1P inhibitors could be potentially used to treat atherosclerosis and prevent stroke.Disclosure: Dr. Jin has nothing to disclose. Dr. Basu has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jin, W., Basu, D. Tags: Cerebrovascular Disease: Animal Models and In Vitro Models Source Type: research

Trends in Cerebral Palsy in Saskatoon, Canada in the Last Four Decades (P6.330)
Conclusions: The KCC database is a valuable resource for longitudinal CP studies. Although improvements in care have resulted in a decreased burden of disability there remains scope for further improvements, especially in improving long term visual function.Disclosure: Dr. Sawicka has nothing to disclose. Dr. Rooks has nothing to disclose. Dr. Dzus has nothing to disclose. Dr. Norton has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sawicka, K., Rooks, K., Dzus, A., Norton, J. Tags: Child Neurology and Developmental Neurology: Other Source Type: research

Factors Delaying Stroke Team Notification in the Emergency Department in Acute Ischemic Stroke Patients Receiving Thrombolytic Treatment (P6.085)
Conclusions: Clinical presentation with 2-3 FAST criteria results in shorter stroke-code activation times compared to 0-1. Improved recognition of common stroke syndromes not accounted for in the FAST criteria by ED personnel is a performance improvement opportunity through expedited stroke team notification and faster door-to-needle treatment times.Disclosure: Dr. Gill has nothing to disclose. Dr. Ray has nothing to disclose. Dr. Eriksson has nothing to disclose. Dr. Durazo-Arvizu has nothing to disclose. Dr. Ruland has received personal compensation for activities with Aztra Zeneca and Boehringer Ingelheim as a consultant and/or speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gill, R., Ray, J., Eriksson, N., Durazo-Arvizu, R., Ruland, S. Tags: Cerebrovascular Disease and Interventional Neurology: Patient Safety and Quality Source Type: research

Statin therapy in acute ischemic stroke: Time for large randomized trials?
Despite improvements in stroke mortality coupled with therapeutic advances, stroke patients often face the prospect of substantial disability. Novel strategies are clearly needed to further improve stroke outcomes. These might include new indications for previously licensed drugs proven effective and safe in related disease processes,1 such as statins. Unlike strong evidence supporting statin use in cardiovascular risk reduction and acute myocardial ischemia, their effects on cerebral tissue and potential benefits on stroke outcomes remain poorly understood and understudied. The only current stroke-specific indication for ...
Source: Neurology - March 21, 2016 Category: Neurology Authors: Charidimou, A., Merwick, A. Tags: All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke
Conclusion: Statin pretreatment in patients with acute LAA appears to be associated with better early outcomes regarding neurologic improvement, disability, survival, and stroke recurrence.
Source: Neurology - March 21, 2016 Category: Neurology Authors: Tsivgoulis, G., Katsanos, A. H., Sharma, V. K., Krogias, C., Mikulik, R., Vadikolias, K., Mijajlovic, M., Safouris, A., Zompola, C., Faissner, S., Weiss, V., Giannopoulos, S., Vasdekis, S., Boviatsis, E., Alexandrov, A. W., Voumvourakis, K., Alexandrov, A Tags: All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage
Conclusion: ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.
Source: Neurology - March 7, 2016 Category: Neurology Authors: Woo, D., Kruger, A. J., Sekar, P., Haverbusch, M., Osborne, J., Moomaw, C. J., Martini, S., Hosseini, S. M., Ferioli, S., Worrall, B. B., Elkind, M. S. V., Sung, G., James, M. L., Testai, F. D., Langefeld, C. D., Broderick, J. P., Koch, S., Flaherty, M. L Tags: Intracerebral hemorrhage ARTICLE Source Type: research

Association of atrial fibrillation with mortality and disability after ischemic stroke
Source: Neurology - February 1, 2016 Category: Neurology Tags: CORRECTIONS Source Type: research

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