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Source: Neurology
Condition: Disability

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Total 221 results found since Jan 2013.

Time-course of functional recovery after acute ischaemic stroke and its relationship to cause-specific mortality: Implications for follow-up of stroke trials (S19.004)
Conclusions:Functional recovery continues to occur between 3 months and 1 year post-stroke, but disability by 3 months strongly predicts long-term stroke-related death/dependency. By extending follow-up to 1 year, trials can capture most salient differences in long-term disability and index-stroke-related deaths.Study Supported by:The Oxford Vascular Study has been funded by the Wellcome Trust, Wolfson Foundation, UK Stroke Association and the NIHR Oxford Biomedical Research Centre. PMR is in receipt of an NIHR Senior Investigator Award and a Wellcome Trust Senior Investigator Award. AG is funded by the Rhodes Trust.Disclo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ganesh, A., Luengo-Fernandez, R., Wharton, R. M., Gutnikov, S. A., Silver, L. E., Mehta, Z., Rothwell, P. M., on behalf of the Oxford Vascular Study Tags: Best Of: Cerbrovascular Disease and Interventional Neurology Source Type: research

Modified Rankin Scale Disability Status at Day 4 Poststroke is an Informative Predictor of Final Day 90 Outcome (P6.271)
Conclusions:In acute stroke patients, the 4d modified Rankin global disability assessment is highly informative regarding final 3 month mRS disability outcome, alone, and even more strongly in combination with baseline prognostic variables. The 4d mRS is a useful measure for imputing final patient disability outcome in clinical trials and quality improvement programs.Disclosure: Dr. Asanad has nothing to disclose. Dr. Starkman has received research support from the National Institute of Health, Stryker, Biogen IDEC, Neuravi, Genentech, Covidien, and Astra-Zeneca. Dr. Hamilton has nothing to disclose. Dr. Conwit has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Asanad, S., Starkman, S., Hamilton, S., Conwit, R., Sanossian, N., Saver, J. Tags: Cerebrovascular Disease Health Services Research Source Type: research

Developing a Family of Visual Decision Aids for Intravenous and Endovascular Reperfusion Therapies for Acute Ischemic Stroke (S25.006)
Conclusions:Personograph visual decision aids are a promising approach to rapidly educating patients, family, and healthcare providers on the benefits and risks of the major reperfusion therapies for acute ischemic stroke.Disclosure: Dr. Tokunboh has nothing to disclose. Dr. Vales Montero has nothing to disclose. Dr. Zopelaro has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Gonzalez has received research support from NIH. Dr. Starkman has received research support from the National Institute of Health, Stryker, Biogen IDEC, Neuravi, Genentech, Covidien, and Astra-Zeneca. Dr. Szeder has nothing to disclose. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tokunboh, I., Montero, M. V., Zopelaro, M., Sharma, L., Gonzalez, N., Starkman, S., Szeder, V., Jahan, R., Liebeskind, D., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Prehospital and Emergency Department Ischemic Stroke Care Source Type: research

Constraint-Induced Movement Therapy for Chronic Hemiparesis: Neuroscience Evidence from Basic Laboratory Research and Quantitative Structural Brain MRI in Patients with Diverse Disabling Neurological Disorders (S43.003)
Conclusions:CIMT is increasing worldwide practice to improve reduced real-world limb use in chronic hemiparesis in diverse neurological diseases and ages of patients. Structural CNS changes following CIMT may support improved and extended functional use of the paretic limb.Study Supported by: NIH, National MS SocietyDisclosure: Dr. Mark has nothing to disclose. Dr. Taub has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mark, V., Taub, E. Tags: Exciting New Results in Neuro-rehabilitation Source Type: research

Thrombolysis for acute ischemic stroke in patients with leukoaraiosis: Caution needed
The term leukoaraiosis (LA), introduced about 30 years ago,1 describes cerebral white matter signal abnormalities (or white matter hyperintensities) commonly observed on structural brain magnetic resonance or CT imaging in elderly individuals. LA severity can be graded using categorical classification, based on different rating scales,2 or continuously, using automatic quantification algorithms. LA has multiple histopathologic correlates, including ependymal loss, cerebral ischemia, demyelination, venous collagenosis, and microcystic infarcts.3 A substantial body of evidence now supports associations between LA and increas...
Source: Neurology - February 12, 2017 Category: Neurology Authors: Streifler, J., Maillard, P. Tags: All Cerebrovascular disease/Stroke, Clinical trials Systematic review/meta analysis, Infarction, Intracerebral hemorrhage EDITORIALS Source Type: research

Telestroke: Is it safe and effective?
In the United States, stroke is the number one cause of disability and one of the leading causes of death. Strokes are treatable, but only if identified and treated quickly. Neurologists have a saying that "time is brain," because the longer a patient with a stroke goes without treatment, the greater number of brain cells that die. This means that the patient is more likely to die or become permanently disabled.
Source: Neurology - September 25, 2016 Category: Neurology Authors: Madhavan, M., Karceski, S. Tags: Stroke prevention, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke PATIENT PAGES Source Type: research

Influence of sodium consumption and associated knowledge on poststroke hypertension in Uganda
Conclusions: High urine sodium and high salt-diet preferences were more frequent among poststroke hypertensive patients in Uganda than in their nonhypertensive counterparts. There was, however, no difference in dietary salt knowledge between these groups. The development of educational strategies that include salt-diet preferences may lead to better blood pressure control in this high-risk population.
Source: Neurology - September 18, 2016 Category: Neurology Authors: Kaddumukasa, M. N., Katabira, E., Sajatovic, M., Pundik, S., Kaddumukasa, M., Goldstein, L. B. Tags: All Cerebrovascular disease/Stroke, Case control studies ARTICLE Source Type: research

Experimental treatments for poststroke disability: Hasten slowly
Sometimes, patients just want us to fix them. In an era of robot-assisted technology and virtual reality, when we hear stories about miraculous recoveries and the seemingly boundless plasticity of the human brain, people are often baffled by the existence of ongoing disability after brain injury. It would be a rare neurologist who has not had a family member attend clinic clutching a stack of printed Internet pages and lamenting the fact that as a society we have been able to put a man on the moon but we cannot fix her or his mother.
Source: Neurology - June 5, 2016 Category: Neurology Authors: Brodtmann, A., Kalra, L. Tags: All Cerebrovascular disease/Stroke, All Rehabilitation EDITORIALS Source Type: research

Practice advisory: Etanercept for poststroke disability: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Conclusions: For patients with poststroke disability, the evidence is insufficient to support or refute a benefit of etanercept for the treatment of poststroke disability. Recommendations: Clinicians should counsel patients considering etanercept for treatment of poststroke disability that the evidence is insufficient to determine the treatment's effectiveness and that it may be associated with adverse outcomes and high cost (Level U).
Source: Neurology - June 5, 2016 Category: Neurology Authors: Gronseth, G. S., Messe, S. R. Tags: All Cerebrovascular disease/Stroke, All Rehabilitation SPECIAL ARTICLE Source Type: research

Restriction of therapy mainly explains lower thrombolysis rates in reduced stroke service levels
Conclusions: Differences in IVT rates among stroke service levels were mainly explained by differences administering IVT to older patients and patients with preexisting disabilities. This indicates considerable further potential to increase IVT rates. Our findings support guideline recommendations to admit acute stroke patients to SUs.
Source: Neurology - May 22, 2016 Category: Neurology Authors: Gumbinger, C., Reuter, B., Hacke, W., Sauer, T., Bruder, I., Diehm, C., Wietholter, H., Schoser, K., Daffertshofer, M., Neumaier, S., Drewitz, E., Rode, S., Kern, R., Hennerici, M. G., Stock, C., Ringleb, P. Tags: Medical care, All Clinical Neurology, Cohort studies, Infarction ARTICLE Source Type: research

Comment: Well-organized stroke service reduces the burden of stroke
The idea, presented here, that emergency medical services transporting acute stroke patients should bypass hospitals without stroke units (SUs) and experience in IV stroke thrombolysis (IVT) is not new, but now it is based on evidence.1 Hospitals without SU and experience in stroke IVT treated fewer potential thrombolysis candidates than experienced stroke centers (SCs). This was the case in patients over 80 years of age and those with preexisting disabilities, although patients treated at SCs with IVT had equally low mortality as the rest of the IVT-treated patients.1 The finding that patients treated off-label with IVT h...
Source: Neurology - May 22, 2016 Category: Neurology Authors: Kaste, M. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies
Conclusions: The incidence of symptomatic hemorrhage or rehemorrhage is higher in brainstem lesions. First symptomatic hemorrhage increases the chance of symptomatic rehemorrhage, which decreases after 2 years.
Source: Neurology - May 22, 2016 Category: Neurology Authors: Taslimi, S., Modabbernia, A., Amin-Hanjani, S., Barker, F. G., Macdonald, R. L. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Incidence studies, Natural history studies (prognosis), Intracerebral hemorrhage ARTICLE Source Type: research

A Survey of Functional Movement Disorders at the National Institutes of Health (P1.073)
OBJECTIVE: To better characterize the clinical presentation of functional movement disorders. BACKGROUND: Functional (psychogenic) movement disorders are receiving greater attention as valid and treatable neurologic disorders. Unfortunately, the often long list of complaints with variable presentations may hamper timely diagnosis and treatment. METHODS: We reviewed 113 charts retrospectively of patients presenting to the National Institutes of Health. Patients were referred from 44 states and the District of Columbia, with the majority presenting from the local Washington D.C. metropolitan area. Most patients were diagnose...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ahmad, O., Maurer, C., Villegas, M. A. F., Lungu, C., Hallett, M. Tags: Movement Disorders: Miscellaneous Source Type: research

Etiologic Epidemiology of Ischemic Stroke (A Study About 2450 Cases) (P1.120)
Conclusions: The main etiology of ischemic stroke in elderly person was lacunar infract followed by atherosclerosis and atrial fibrillation. In Young adults, etiology differs according to country. In our study Carotid dissection takes the first place in patients with age under 45 years old Etiological investigations and a swift implementation of strategy for the prevention of the risk factors are important faced with increased incidence of ischemic stroke. Despite a complete assessment, ischemic stroke etiology can remain indeterminate.Disclosure: Dr. bouzidi has nothing to disclose. Dr. AYADI has nothing to disclose. Dr. ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Bouzidi, N., Ayadi, B., Bouchhima, I., Turki, E., Damak, M., Mhiri, C. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Why Delay the Control of Modifiable Vascular Risk Factors (MVRF) Until the Occurrence of an Ischemic Stroke (iStroke)? (P1.180)
Conclusions: We found that the management of MVRF increases after the first ischemic event and this improves the early prognosis of iStroke (Rankin-based disability). It is important to improve the management of these factors in the setting of primary prevention.Disclosure: Dr. Pagano Ajolfi has nothing to disclose. Dr. Sanz has nothing to disclose. Dr. Alfonso has nothing to disclose. Dr. Seijas has nothing to disclose. Dr. Arrébola has nothing to disclose. Dr. Giannaula has received personal compensation for activities with Boehringer Ingelheim.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Pagano Ajolfi, S., Sanz, P., Alfonso, A., Seijas, M., Arrebola, M., Giannaula, R. Tags: Cerebrovascular Disease: Risk Factors and Prevention Source Type: research