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Source: Neurology
Condition: Thrombosis

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Total 223 results found since Jan 2013.

Editors' Note
: In "Evaluating the safety of β-interferons in MS: A series of nested case-control studies," de Jong et al. found that exposure to β-interferons was associated with a 1.8-fold increased risk of stroke. Commenting on the study, Dr. Jongen shares his own prospective study on adverse events in 284 patients with multiple sclerosis treated with intramuscular interferon-β-1a: one patient died from a stroke sinus thrombosis 22 months after start of treatment.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Karam, C., Griggs, R. C. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Teaching NeuroImages: Artery of Percheron thrombosis causing selective downgaze palsy
A 47-year-old man with migraines presented with sudden onset of vertical diplopia, dysarthria, right facial weakness, and downgaze palsy (figure 1). Brain MRI revealed ischemic strokes in the midbrain periaqueductal gray, bilateral thalamic–midbrain junction, and thalamus (figure 2, A–C). Gradient echo and T1 MRI showed hypointensity in the interpeduncular fossa (figure 2, D and E). No flow could be visualized in this structure on CT angiogram or catheter angiogram, demonstrating a thrombosed artery of Percheron (figure 2, F–H). Downgaze palsy, which improved 18 months later, may result from bilateral les...
Source: Neurology - October 16, 2017 Category: Neurology Authors: Sechler, M., Singh, J., El Husseini, N. Tags: MRI, DWI, All Cerebrovascular disease/Stroke, Infarction RESIDENT AND FELLOW SECTION Source Type: research

Pearls & Oy-sters: An uncommon initial presentation of thyrotoxicosis
Venous thrombosis is common in patients with thyrotoxicosis, with the cerebral venous system being frequently involved.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Grewal, P. K., Villamar, M. F., Raslau, F. D., Dobbs, M. R. Tags: Stroke in young adults, Endocrine, All Cerebrovascular disease/Stroke, Cerebral venous thrombosis RESIDENT AND FELLOW SECTION Source Type: research

Clinical Reasoning: Acute onset facial droop in a 36-year-old pregnant woman
A 36-year-old woman, G1P0, 22 weeks pregnant, presented to the emergency department for evaluation of acute onset facial droop. Her medical history included ulcerative colitis, primary sclerosing cholangitis, and heterozygosity for the prothrombin G20210A mutation. She was on 10,000 units of subcutaneous heparin twice daily for a previous deep vein thrombosis secondary to her prothrombin mutation; she was noncompliant with prescribed aspirin.
Source: Neurology - June 12, 2017 Category: Neurology Authors: George, I. C., Youn, T. S., Marcolini, E. G., Greer, D. M. Tags: Other cerebrovascular disease/ Stroke, Autoimmune diseases, Critical care, All Demyelinating disease (CNS) RESIDENT AND FELLOW SECTION Source Type: research

What are the barriers for use of pharmacological prophylaxis (PP) to prevent deep vein thrombosis (DVT) in spontaneous intracranial bleeding (sICH)? (P2.253)
Conclusions:Following this QI project, we started a new pilot study where DVT prophylaxis advisor was included in all stroke admission orders. The pilot project was successful and DVT prophylaxis advisor is now included permanently to all stroke admission orders including the intracranial hemorrhage. We hope this will ensure patients are started on prophylactic anticoagulation per guidelines.Disclosure: Dr. Jayaraman has nothing to disclose. Dr. Sapnar has nothing to disclose. Dr. Joe has nothing to disclose. Dr. Edara has nothing to disclose. Dr. Yaddanapudi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Jayaraman, D. K., Sapnar, S., Joe, J., Edara, A., Yaddanapudi, S. Tags: Intracerebral Hemorrhage Source Type: research

Resumption of Antithrombotic Therapy in LVAD-associated Intracranial Hemorrhages (P2.273)
Conclusions:Among survivors of LVAD-associated ICH, those who resumed both antiplatelet plus warfarin therapy had fewer ischemic, but more hemorrhagic events than those who resumed antiplatelet therapy alone.Disclosure: Dr. Cho has nothing to disclose. Dr. Frontera has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Cho, S.-M., Frontera, J. Tags: Intracerebral Hemorrhage Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Quality of Stroke Care Among Ischemic Stroke Patients Discharged from Non-Neurology Services (P2.068)
Conclusions:CSC designation is associated with improvement in several quality metrics among AIS patients discharged from non-neurology services. Areas for improvement remain, particularly in the provision of dysphagia screening and stroke education.Disclosure: Dr. Gibson has nothing to disclose. Dr. Albright has nothing to disclose. Dr. Ellison has nothing to disclose. Dr. Lyerly has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Gibson, E., Albright, K., Ellison, J., Lyerly, M. Tags: Practice, Policy, and Ethics II Source Type: research

Hyperacute Carotid Stenting for Acute Ischemic Stroke After Systemic Thrombolysis with IV rt-PA (P1.282)
Conclusions:These 2 cases demonstrate a successful use of hyperacute carotid stenting and antiplatelet load in patients who received systemic thrombolysis with IV rt-PA. Both had excellent outcomes and no complications. This management may be considered in patients with similar clinical and imaging characteristics.Disclosure: Dr. Marulanda-Londoño has nothing to disclose. Dr. DeLeon-Bendetti has nothing to disclose. Dr. Ortiz has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Marulanda-Londono, E., DeLeon-Bendetti, A., Ortiz, G. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Paradoxical Embolism in the Setting of Inferior Vena Cava Filter Removal (P1.283)
Conclusions:Although clinically relevant events secondary to IVC filter migration and fracture are rare, they can be life-threatening. Care should be taken when choosing to place these devices, and alternative therapies should be considered when possible. They should be removed when no longer needed, as fracture rates are increased with longer dwell times. Up to half of complications can be avoided with retrieval within 3 months.Disclosure: Dr. Yost has nothing to disclose. Dr. Klaas has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yost, M., Klaas, J. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Aortic Valvular Papillary Fibroelastoma Leading to Acute Ischemic Stroke in a Pediatric Patient (P1.286)
Conclusions:Previously published cases of children with IS and PF have identified the mitral valve as the site of the PF. Our case demonstrates that aortic valvular PF can be associated with IS in pediatric patients. Resection of symptomatic PF is recommended to prevent further cardio-embolic strokes.Disclosure: Dr. Farooqui has nothing to disclose. Dr. Mannel has nothing to disclose. Dr. Silliman has received research support from Sanofi Genzyme, Biogen Idec, Bristol Myers and Novartis.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Farooqui, I., Mannel, R., Silliman, S. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Recurrent ischemic strokes as the initial presentation of thrombotic thrombocytopenic purpura with normal platelets: a case report. (P1.296)
Conclusions:Recurrent strokes in multiple vascular territories should prompt suspicion of hypercoagulable, cardioembolic, or vasculitis/opathy. TTP can be a cause of hypercoagulability in patients with cryptogenic stroke even without major hematologic abnormalities. TTP is treatable with plasma exchange and immunosuppression. Thus, one must consider TTP even in the absence of hematologic abnormalities, especially in a young patient with no stroke risk factors and otherwise negative stroke work-up.Disclosure: Dr. Horton has nothing to disclose. Dr. Doyle has nothing to disclose. Dr. Powell has received research support from...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Horton, L., Doyle, A., Powell, C., Gebreyohanns, M. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Age, Gender and Racial Disparities in Acute Stroke Therapy in a Large Non-Academic Health System (P3.261)
Conclusions:We confirmed known disparities in ATT rates between PSC and AH. No disparity in age or gender were identified in this population. Racial disparity was problematic because of a small number of non-white patients and a number of patients with no racial data captured. Better racial data collection, analysis of access to care, and care process modeling might impact these findings.Disclosure: Dr. Taylor has nothing to disclose. Dr. Jones has received personal compensation for activities with Genentech as a speaker. Dr. Gosnell has nothing to disclose. Dr. Snyder has nothing to disclose. Dr. Schneider has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Taylor, R., Jones, R., Gosnell, J., Snyder, S., Schneider, A. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Characteristics of In-Flight Stroke in Korea (P3.264)
Conclusions:In-flight stroke is uncommon, and can easily be neglected during flight, which result in poor outcome. The stroke risk seems to be relatively high around landing, especially in the travelers with short flight time, and the mechanism of stroke onset during landing needs to be investigated.Disclosure: Dr. Park has nothing to disclose. Dr. Yoon has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Oh has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Rha has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Park, H. K., Yoon, C., Lee, E.-S., Oh, D. A., Park, H. I., Lee, S. W., Rha, J.-H., Bae, E.-K. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Streptococcus pneumoniae meningitis and intracranial vasculopathy: Clinical correlation with improving transcranial Doppler hemodynamics (P1.322)
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Idris, M. I., Tai, S. M. L., Tan, C. T., Tan, K. S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research