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Source: Neurology
Condition: Hypertension

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Total 378 results found since Jan 2013.

Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity
Conclusions: IR is associated with impaired CVR; the relationship appears to be driven by the degree of IR and not by obesity. These rarely reported results suggest that early forms of cerebrovascular dysfunction exist among obese middle-aged individuals with significant IR but without type 2 diabetes mellitus. These functional vascular abnormalities may help explain the associations among IR, diabetes, and dementia, and suggest that interventions aiming to improve IR or CVR may help prevent cognitive decline later in life.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Frosch, O. H., Yau, P. L., Osorio, R. S., Rusinek, H., Storey, P., Convit, A. Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013
Conclusions: In 2002–2013, the incidence of stroke in China increased rapidly. Combined with a high prevalence, a trend toward a younger age, and stable mortality, this finding suggests that additional clinical and behavioral interventions for metabolic and lifestyle risk factors are necessary to prevent stroke, particularly in certain populations.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Guan, T., Ma, J., Li, M., Xue, T., Lan, Z., Guo, J., Shen, Y., Chao, B., Tian, G., Zhang, Q., Wang, L., Liu, Y. Tags: All Cerebrovascular disease/Stroke, Prevalence studies, Incidence studies, Risk factors in epidemiology ARTICLE Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Teaching NeuroImages: Acute infarction of the left medial lemniscus masquerading as a peripheral neuropathy
A 58-year-old woman with hypertension and bilateral carpal tunnel syndrome presented with acute paresthesias in her right hand and foot. She had decreased sensation to vibration and pinprick in a right-sided stocking-glove distribution. MRI of the pons confirmed an acute infarction of a paramedian branch of the basilar artery in the left medial lemniscus (figure). In the posterior column pathway, sensory projections from the face, arm, and leg are somatotopically arranged medially to laterally within the medial lemniscus.1,2 Although strokes classically present with numbness, both thalamic and medial lemniscal infarcts can...
Source: Neurology - April 24, 2017 Category: Neurology Authors: Aamodt, W. W., Siegler, J. E., Elman, L. Tags: MRI, DWI, All Cerebrovascular disease/Stroke, Central pain, Infarction RESIDENT AND FELLOW SECTION Source Type: research

To study the impact of chronic vasodilator therapy on perihematomal edema in primary intracerebral hemorrhage(ICH) (P2.259)
Conclusions:Though limited by small sample size, this retro spective study suggests that chronic vasodilator therapy may serve to prevent worsening cerebral edema. This is a tantalizing finding that, if confirmed, could lead to potential pharmacological interventions for patients with ICH. Further prospective studies evaluating the effect of vasodilators in this patient population will be required.Disclosure: Dr. Singh has nothing to disclose. Dr. Albright has nothing to disclose. Dr. Pennington has nothing to disclose. Dr. Gupta has nothing to disclose. Dr. Shapshak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Singh, M., Albright, K., Pennington, A., Gupta, S., Shapshak, A. H. Tags: Intracerebral Hemorrhage Source Type: research

Clinical presentation and outcomes of young adults enrolled in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study (P2.267)
Conclusions:Young white patients with ICH may have worse outcomes than young black or Hispanic patients. Our results may be limited by selection bias, as enrolled cases are younger and more likely to be black or Hispanic than non-enrolled.Disclosure: Dr. Miyares has nothing to disclose. Dr. Leasure has nothing to disclose. Dr. Kittner has nothing to disclose. Dr. Langefeld has nothing to disclose. Dr. Vagal has nothing to disclose. Dr. Sheth has received personal compensation in an editorial capacity Current Treatment Options in Neurology. Dr. Sheth has received research support from Remedy Pharmaceuticals, Inc. Dr. Woo ha...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Miyares, L., Leasure, A., Kittner, S., Langefeld, C., Vagal, A., Sheth, K., Woo, D. Tags: Intracerebral Hemorrhage Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Trends and Predictors of Utilization of Endovascular Coiling vs Microsurgical Clipping of Ruptured Intracranial Aneurysms (P2.292)
Conclusions:Study highlights significant increase in utilization rates of coiling over the past eleven years for RIA in USA.Disclosure: Dr. Balasetti has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Jani has nothing to disclose. Dr. To has nothing to disclose. Dr. Fessler has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Balasetti, V., Patel, U., Jani, V., To, C. Y., Fessler, R. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Zika associated Guillain-Barre syndrome in the United States (P2.327)
Conclusions:Zika can induce GBS after a brief viral illness. Neuropathy can be a mixture of demyelinating and axonal. Dysautonomia may also be present including severe dysphagia, orthostatics and retention.Zika RNA has a short detection window in serum and CSF making a diagnosis time sensitive. Serological assays using IgM and IgG cross-react with other flaviviruses making them unable to differentiate between recent Zika exposure and cross reactivity with Dengue and Chikungunya. Our pt likely had prior exposure to Dengue, being from an endemic area. Prior Dengue exposure may possibly modulate the response to Zika via antib...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tantillo, G., Sclar, G., Vasa, C., Shin, S., Sivak, M. Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections I Source Type: research

Is fabrys disease a risk factor for stroke in young patients? (p1.252)
Conclusions:Although as much as 40% of young patients with ischemic stroke have no clear etiology, extensive investigation for possibly treatable causes is warranted and should include Fabry’s Disease.Disclosure: Dr. Ikuta has nothing to disclose. Dr. Scavasine has nothing to disclose. Dr. Canever has nothing to disclose. Dr. Zamproni has nothing to disclose. Dr. Lange has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Zetola has nothing to disclose. Dr. Werneck has nothing to disclose. Dr. Novak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ikuta, C., Scavasine, V., Canever, M., Zamproni, L., Lange, M., Germiniani, F., Zetola, V., Werneck, L., Novak, E. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

The relationship between chemerin levels and carotid intima-media thickness in patients with ischemic stroke (P1.262)
Conclusions:Consequently, this study showed that serum chemerin levels may play role in atherosclerosis and ischemic stroke.Study Supported by: Fırat University (FÜBAP)Disclosure: Dr. Demir has nothing to disclose. Dr. Atas has nothing to disclose. Dr. Aytaç has nothing to disclose. Dr. Gonen has nothing to disclose. Dr. Erten has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Demir, C., Ataş, I., Aytac, E., Gonen, M., Erten, Z. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Patient characteristics affecting stroke recognition by emergency medical service providers in Kings County Hospital Center (P1.270)
Conclusions:More than half of actual stroke patients were missed in the field in our study. Our study identifies potential patient characteristics affecting stroke recognition by EMS.Disclosure: Dr. Cuascut Lassus has nothing to disclose. Dr. Law has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lassus, F. C., Law, S. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research

A Rare Case of Central Nervous System Tuberculosis Presenting as Transient Splenial Lesion: Case Report and Literature Review (P1.320)
Conclusions:Based on literature review, the transient splenial lesion of corpus callosum has never been reported in patients with CNS tuberculosis. The mechanisms underlying transient splenial lesions may due to intramyelinic edema and inflammatory cell infiltration. This hypothesis supported by the MR spectroscopy findings in our patient. Since early diagnosis and treatment can reduce mortality and morbidity, patients with isolated splenial lesion warrant diagnostic tests for CNS tuberculosis.Study Supported by:The authors report no disclosures relevant to the manuscript.Disclosure: Dr. Wu has nothing to disclose. Dr. Che...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wu, J.-W., Chen, S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Predictive Variables of Cognitive Dysfunction in Patients with Lupus (P1.340)
Conclusions:Duration of disease and low educational level are predictors of CD in patients with SLE. Depression and anxiety did not influence cognitive performance. Although cardiovascular comorbidity is a risk factor for dementia in general population, those variables might play a minor role in SLE patients.Study Supported by:Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and São Paulo Research Foundation (FAPESP) (grant #2015/08833-7) supported this study.Disclosure: Dr. Alessi has nothing to disclose. Dr. Dutra Antonio has nothing to disclose. Dr. Maria has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Alessi, H., Dutra, L. A., Maria, L., Xavier, P., Couce, P., Kayser, C., Barsottini, O. Tags: CNS Inflammatory Diseases and Differential Diagnosis I Source Type: research

Man-in-the-barrel syndrome with Delayed Diffusion-weighted MRI Findings (P3.072)
Conclusions:DWI has a high degree of sensitivity and specificity. Nevertheless, false negative results often occur because of small infarct size, early imaging, and brainstem locations. The rate of false negative results with DWI has been estimated to be 17%. We argue it may be advisable to repeat MRI in certain cases were stroke is highly suspected up to 72 hours post symptoms. Often false negative DWI occur in posterior circulation strokes making our case unique, given it is in the anterior circulation. One possible explanation for this, is differences in cerebral reserve between a young patient versus an older patient d...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Magun, R., Ching, M., Sawyer, R., Mowla, A. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research