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Source: Epilepsy Curr
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Total 106 results found since Jan 2013.
Genetics of Dravet Syndrome and its Targeted Therapy by Nanomedicine: A Roadmap for Future Treatment of Drug Resistant Seizures
Curr Mol Pharmacol. 2022 Aug 19. doi: 10.2174/1874467215666220819143105. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), epilepsy is the 4th most prevalent neurological disorder after migraine, stroke, and Alzheimer's disease. There are numerous types of epileptic syndrome that are reported in children; one of them is Dravet syndrome. It is a neurological disorder of infants' outset during the first year of life. Dravet syndrome is a genetically determined syndrome and the most studied form of genetic epilepsy. Nearly 70-80% of its cases are due to genetic alterations in the SCN1A gene, and ...
Source: Epilepsy Curr - August 20, 2022 Category: Neurology Authors: Muhammad Ikram Sufian Rasheed Source Type: research
Epilepsy in Cerebrovascular Diseases: A Narrative Review
CONCLUSION: Some aspects of ES and PSE have been well explored, particularly epidemiology and risk factors. On the contrary, few data exist on physiopathology, and existing evidence is mainly based on studies on animal models. Little is also known on seizure semiology, which may also be difficult to interpret by non-epileptologists. Moreover, the therapeutic approach needs standardization as regards indications and the choice of specific ASMs. Future research may help to better elucidate these aspects.PMID:35794769 | DOI:10.2174/1570159X20666220706113925
Source: Epilepsy Curr - July 7, 2022 Category: Neurology Authors: S Neri S Gasparini A Pascarella D Santangelo V Cianci A Mamm ì M Lo Giudice E Ferlazzo U Aguglia Source Type: research
LTBP1 Gene Expression in the Cerebral Cortex and Its Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy
CONCLUSION: LTBP1 can affect the changes in inflammation-related pathways by activating TGFβ/SMAD signaling pathway, stimulate the development of epilepsy, and the inhibition of LTBP1 expression can control the occurrence of epilepsy, with neuroprotection.PMID:35676846 | DOI:10.2174/1389201023666220608091511
Source: Epilepsy Curr - June 9, 2022 Category: Neurology Authors: Bo Liu Yan Wang Dongruo He Guochao Han Hao Wang Yuan Lin Tianyu Zhang Chao Yi Hui Li Source Type: research
