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Bradyarrhythmias in patients with atrial fibrillation
The increasing burden of atrial fibrillation (AF) and significant morbidity/mortality associated with this arrhythmia encourage screening it in clinical practice, as recommended in current guidelines. It means opportunistic screening (in patients over 65 years) or systematic screening (in people above 75 years) by using clinical examination, followed by an ECG, 24-hour ECG monitoring or continuous rhythm monitoring by a screening tool (including mobile or wearable device). In screen-positive cases, a definitive diagnosis of AF should always be obtained before providing an appropriate management.1 Symptomatic or asymptomati...
Source: Heart - August 11, 2023 Category: Cardiology Authors: Floria, M., Tanase, D. M. Tags: Editorials Source Type: research

Heartbeat: prediction of atrial fibrillation risk
One of the challenges in prevention of stroke is identification of patients at risk of atrial fibrillation (AF) shortly before the onset of the arrhythmia so that prevention therapies can be promptly instituted. In this issue of Heart, Nadarajah and colleagues1 report the development and validation of an algorithm based on data from the UK Clinical Practice Research Datalink GOLD dataset that included 2 081 139 individuals of whom 7386 developed AF within 6 months. This new algorithm-- Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF) – identified a high-risk cohort with a 20-fold higher 6 month ...
Source: Heart - June 26, 2023 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

Prediction of short-term atrial fibrillation risk using primary care electronic health records
Conclusions FIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Nadarajah, R., Wu, J., Hogg, D., Raveendra, K., Nakao, Y. M., Nakao, K., Arbel, R., Haim, M., Zahger, D., Parry, J., Bates, C., Cowan, C., Gale, C. P. Tags: Open access, Editor's choice Arrhythmias and sudden death Source Type: research

Impact of pre-existing left atrial appendage occluder on catheter ablation of atrial fibrillation
Conclusions This pioneer study first showed impacts of LAAO on LA substrate and PVI procedure.
Source: Heart - May 26, 2023 Category: Cardiology Authors: Chen, J.-J., Chiu, F.-C., Chang, S.-N., Cheng, H.-L., Huang, P.-s., Wu, C.-K., Wang, Y.-C., Hwang, J.-J., Tsai, C.-T. Tags: Arrhythmias and sudden death Source Type: research

Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes
Conclusions In the general population, echocardiographic left atrial volumetric indices and NT-proBNP, but not cTnT and GDF-15, associate with prevalent atrial fibrillation and with risk of incident atrial fibrillation. cTnT and NT-proBNP provide incremental prognostic information to echocardiography.
Source: Heart - February 14, 2023 Category: Cardiology Authors: Lyngbakken, M. N., Ronningen, P. S., Solberg, M. G., Berge, T., Brynildsen, J., Aagaard, E. N., Kvisvik, B., Rosjo, H., Steine, K., Tveit, A., Omland, T. Tags: Arrhythmias and sudden death Source Type: research

Cryoballoon Pulmonary Vein Isolation as First-Line Treatment for Typical Atrial Flutter
Conclusion Cryoballoon PVI as first-line treatment for AFL is equally effective compared with standard CTI ablation for preventing recurrence of atrial arrhythmia and better at preventing new-onset AF. Trial registration number NCT03401099.
Source: Heart - February 14, 2023 Category: Cardiology Authors: Gupta, D., Ding, W. Y., Calvert, P., Williams, E., Das, M., Tovmassian, L., Tayebjee, M. H., Haywood, G., Martin, C. A., Rajappan, K., Bates, M. G. D., Temple, I. P., Reichlin, T., Chen, Z., Balasubramaniam, R. N., Ronayne, C., Clarkson, N., Morgan, M., B Tags: Arrhythmias and sudden death Source Type: research

Left atrial appendage preservation versus closure during surgical ablation of atrial fibrillation
Conclusions LAA preservation during surgical AF ablation was not associated with an increased risk of stroke or mortality. Postoperative LA transport functions were more favourable with LAA preservation than with LAA closure.
Source: Heart - November 10, 2022 Category: Cardiology Authors: Kim, H. J., Chang, D.-H., Kim, S.-O., Kim, J. K., Kim, K., Jung, S.-H., Lee, J. W., Kim, J. B. Tags: Arrhythmias and sudden death Source Type: research

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank
Conclusion Around 80% of participants diagnosed with AF in the UK population are eligible for early rhythm-control. Early rhythm-control therapy was safe in routine care.
Source: Heart - November 10, 2022 Category: Cardiology Authors: Kany, S., Cardoso, V. R., Bravo, L., Williams, J. A., Schnabel, R., Fabritz, L., Gkoutos, G. V., Kirchhof, P. Tags: Open access Arrhythmias and sudden death Source Type: research

Proteomics profiling reveals a distinct high-risk molecular subtype of hypertrophic cardiomyopathy
Conclusions Our prospective plasma proteomics study not only exhibited the presence of HCM molecular subtypes but also identified pathobiological mechanisms associated with a distinct high-risk subtype of HCM.
Source: Heart - October 28, 2022 Category: Cardiology Authors: Liang, L. W., Raita, Y., Hasegawa, K., Fifer, M. A., Maurer, M. S., Reilly, M. P., Shimada, Y. J. Tags: Heart failure and cardiomyopathies Source Type: research

Sex-specific differences in adverse outcome events among patients with atrial fibrillation
Conclusion In this large study of patients with established AF, women had a lower risk of death than men, but there were no sex-specific differences in other adverse outcomes.
Source: Heart - August 25, 2022 Category: Cardiology Authors: Evers-Dörpfeld, S., Aeschbacher, S., Hennings, E., Eken, C., Coslovsky, M., Rodondi, N., Beer, J. H., Moschovitis, G., Ammann, P., Kobza, R., Ceylan, S., Krempke, M., Meyer-Zürn, C. S., Moutzouri, E., Springer, A., Sticherling, C., Bonati, Tags: Arrhythmias and sudden death Source Type: research

Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.
Source: Heart - July 13, 2022 Category: Cardiology Authors: Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., Chudasama, Y. V., Rowlands, A. V., Davies, M. J., McCann, G. P., Banerjee, A., Lam, C. S. P., Docherty, A. B., Openshaw, P. J., Baillie, J. K., Semple, M. G., Lawson, C. A., Khunt Tags: Open access Cardiac risk factors and prevention Source Type: research

Atrial fibrillation following transcatheter atrial septal defect closure: a systematic review and meta-analysis
Conclusions The incidence of new-onset AFi/AFl is relatively low following transcatheter closure of secundum ASDs. The rate of de novo AFi/AFl, however, was significantly higher in elderly patients. Shorter follow-up time was associated with a higher reported incidence of AFi/AFl.
Source: Heart - July 13, 2022 Category: Cardiology Authors: Himelfarb, J. D., Shulman, H., Olesovsky, C. J., Rumman, R. K., Oliva, L., Friedland, J., Farrell, A., Huszti, E., Horlick, E., Abrahamyan, L. Tags: Congenital heart disease Source Type: research

Management and outcomes of patients with left atrial appendage thrombus prior to percutaneous closure
Conclusion In the presence of LAA thrombus, IAT was the initial management strategy in half of our cohort, with initial thrombus resolution in 60% of these, but with a relatively high bleeding rate (~10%). Direct LAAC was feasible, with high procedural success and absence of periprocedural embolic complications. However, a high rate of device-related thrombosis was detected during follow-up.
Source: Heart - June 24, 2022 Category: Cardiology Authors: Marroquin, L., Tirado-Conte, G., Pracon, R., Streb, W., Gutierrez, H., Boccuzzi, G., Arzamendi-Aizpurua, D., Cruz-Gonzalez, I., Ruiz-Nodar, J. M., Kim, J.-S., Freixa, X., Lopez-Minguez, J. R., De Backer, O., Ruiz-Salmeron, R., Dominguez, A., McInerney, A. Tags: Open access Arrhythmias and sudden death Source Type: research

Prediction of incident atrial fibrillation in community-based electronic health records: a systematic review with meta-analysis
Conclusions Models externally validated for prediction of incident AF in community-based EHR demonstrate moderate predictive ability and high risk of bias. Novel methods may provide stronger discriminative performance. Systematic review registration PROSPERO CRD42021245093.
Source: Heart - June 10, 2022 Category: Cardiology Authors: Nadarajah, R., Alsaeed, E., Hurdus, B., Aktaa, S., Hogg, D., Bates, M. G. D., Cowan, C., Wu, J., Gale, C. P. Tags: Open access Arrhythmias and sudden death Source Type: research

Trends in the pharmacological management of atrial fibrillation in UK general practice 2008-2018
Conclusions There has been an increase in the proportion of patients with AF appropriately prescribed anticoagulants following National Institute for Health and Care Excellence and European Society of Cardiology guidelines, which correlates with improvements in mortality and stroke outcomes. Beta-blockers appear increasingly favoured over digoxin for rate control. There has been a steady decline in GP prescribing rates for rhythm control drugs, possibly related to concerns over efficacy and safety and increased availability of AF ablation.
Source: Heart - March 10, 2022 Category: Cardiology Authors: Phillips, K., Subramanian, A., Thomas, G. N., Khan, N., Chandan, J. S., Brady, P., Marshall, T., Nirantharakumar, K., Fabritz, L., Adderley, N. J. Tags: Arrhythmias and sudden death Source Type: research

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