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SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury
CONCLUSION: These findings substantiate the vital role of the SIRT1/p53 axis in mediating ferroptosis in HS-ALI, suggesting that targeting SIRT1 may represent a novel therapeutic strategy to ameliorate ALI during HS.PMID:35853732 | DOI:10.1080/02656736.2022.2094476
Source: International Journal of Hyperthermia - July 19, 2022 Category: Internal Medicine Authors: Hui Chen Xiaoping Lin Xiaohong Yi Xiaofeng Liu Ranghui Yu Wenhao Fan Yaping Ling Yanan Liu Weidang Xie Source Type: research

Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells
CONCLUSION: Our results indicate that UCP2 protects against HS-induced vascular endothelial damage and that it enhances mitochondrial function. These findings reveal that UCP2 can be a potential contributor to mechanism-based therapeutic strategies for HS.PMID:35129048 | DOI:10.1080/02656736.2022.2032846
Source: International Journal of Hyperthermia - February 7, 2022 Category: Internal Medicine Authors: Wei Huang Liangfeng Mao Weidang Xie Sumin Cai Qiaobing Huang Yanan Liu Zhongqing Chen Source Type: research

Clinical characteristics and risk factors of male exertional heatstroke in patients with myocardial injury: an over 10-year retrospective cohort study
CONCLUSION: Patients with heatstroke having MI had more severe clinical conditions, 90-day mortality was significantly increased, and the survival time was shortened. A high SOFA score is an independent risk factor for death in patients with heatstroke having MI, with an optimal cutoff value of 7.5, sensitivity of 91.7%, and specificity of 94.6%.PMID:34157921 | DOI:10.1080/02656736.2021.1941312
Source: International Journal of Hyperthermia - June 23, 2021 Category: Internal Medicine Authors: Li Zhong Jingjing Ji Conglin Wang Zhifeng Liu Source Type: research

Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats
Conclusion: In conclusion, EP ameliorated HS-induced inflammatory responses and MOD, and the underlying mechanism is associated with the induction of the stress proteins HO-1 and HSP70 as well as restorage of autophagy.PMID:34078225 | DOI:10.1080/02656736.2021.1931479
Source: International Journal of Hyperthermia - June 3, 2021 Category: Internal Medicine Authors: Je-Ming Hu Chih-Hsueng Hsu Yu-Chun Lin Ching-Wen Kung Shu-Ying Chen Wen-Ting Lin Pao-Yun Cheng Hsin-Hsueh Shen Yen-Mei Lee Source Type: research

Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury.
Conclusion: This study provides strong evidence that HS causes damage to both the small intestine and intestinal epithelial cells, scavenging ROS production can significantly alleviate such RIPK1/RIPK3-dependent necroptosis, mediating HS-induced intestinal damage both in vitro and in vivo. These findings provide a clear target for future mechanism-based therapeutic strategies for patients diagnosed with heat stroke. PMID: 32423248 [PubMed - in process]
Source: International Journal of Hyperthermia - May 21, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Haemodynamic changes during hyperthermic intra-thoracic chemotherapy for pseudomyxoma peritonei.
CONCLUSIONS: Significant haemodynamic instability including cardiac asystole has been reported during HITOC. The application of hyperthermic agents to the thorax results in vasodilatation, cardiac warming and compression of mediastinal vessels. Measurement of haemodynamic variables allowed careful titration of intravenous fluid therapy to CO and stroke volume, allowing for haemodynamic stability. This has not been described elsewhere. PMID: 28540781 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - May 26, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research