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Source: Cochrane Database of Systematic Reviews
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Total 466 results found since Jan 2013.
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the detection of dementia within community dwelling populations
CONCLUSIONS: Published data suggest that if using the IQCODE for community dwelling older adults, the 16 item IQCODE may be preferable to the traditional scale due to lesser test burden and no obvious difference in accuracy. Although IQCODE test accuracy is in a range that many would consider 'reasonable', in the context of community or population settings the use of the IQCODE alone would result in substantial misdiagnosis and false reassurance. Across the included studies there were issues with heterogeneity, several potential biases and suboptimal reporting quality.PMID:34278562 | DOI:10.1002/14651858.CD010079.pub3
Source: Cochrane Database of Systematic Reviews - July 19, 2021 Category: General Medicine Authors: Terry J Quinn Patricia Fearon Anna H Noel-Storr Camilla Young Rupert McShane David J Stott Source Type: research
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the early detection of dementia across a variety of healthcare settings
CONCLUSIONS: Included studies were heterogenous, recruited from specialist settings, and had potential biases. The studies identified did not allow us to make specific recommendations on the use of the IQCODE for the future detection of dementia in clinical practice. The included studies highlighted the challenges of delayed verification dementia research, with issues around prevalent dementia assessment, loss to follow-up over time, and test non-completion potentially limiting the studies. Future research should recognise these issues and have explicit protocols for dealing with them.PMID:34275145 | DOI:10.1002/14651858.CD011333.pub3
Source: Cochrane Database of Systematic Reviews - July 18, 2021 Category: General Medicine Authors: Jennifer K Burton David J Stott Rupert McShane Anna H Noel-Storr Rhiannon S Swann-Price Terry J Quinn Source Type: research
Non-pharmacological interventions for spatial neglect or inattention following stroke and other non-progressive brain injury
CONCLUSIONS: The effectiveness of non-pharmacological interventions for spatial neglect in improving functional ability in ADL and increasing independence remains unproven. Many strategies have been proposed to aid rehabilitation of spatial neglect, but none has yet been sufficiently researched through high-quality fully powered randomised trials to establish potential or adverse effects. As a consequence, no rehabilitation approach can be supported or refuted based on current evidence from RCTs. As recommended by a number of national clinical guidelines, clinicians should continue to provide rehabilitation for neglect tha...
Source: Cochrane Database of Systematic Reviews - July 1, 2021 Category: General Medicine Authors: Verity Longley Christine Hazelton Calvin Heal Alex Pollock Kate Woodward-Nutt Claire Mitchell Gorana Pobric Andy Vail Audrey Bowen Source Type: research
Interventions for reducing sedentary behaviour in people with stroke
CONCLUSIONS: Sedentary behaviour research in stroke seems important, yet the evidence is currently incomplete, and we found no evidence for beneficial effects. Current World Health Organization (WHO) guidelines recommend reducing the amount of sedentary time in people with disabilities, in general. The evidence is currently not strong enough to guide practice on how best to reduce sedentariness specifically in people with stroke. More high-quality randomised trials are needed, particularly involving participants with mobility limitations. Trials should include longer-term interventions specifically targeted at reducing tim...
Source: Cochrane Database of Systematic Reviews - June 29, 2021 Category: General Medicine Authors: David H Saunders Gillian E Mead Claire Fitzsimons Paul Kelly Frederike van Wijck Olaf Verschuren Karianne Backx Coralie English Source Type: research
Interventions for reducing sedentary behaviour in community-dwelling older adults
CONCLUSIONS: It is not clear whether interventions to reduce sedentary behaviour are effective at reducing sedentary time in community-dwelling older adults. We are uncertain if these interventions have any impact on the physical or mental health of community-dwelling older adults. There were few studies, and the certainty of the evidence is very low to low, mainly due to inconsistency in findings and imprecision. Future studies should consider interventions aimed at modifying the environment, policy, and social and cultural norms. Future studies should also use device-based measures of sedentary time, recruit larger sampl...
Source: Cochrane Database of Systematic Reviews - June 25, 2021 Category: General Medicine Authors: Sebastien Chastin Paul A Gardiner Juliet A Harvey Calum F Leask Javier Jerez-Roig Dori Rosenberg Maureen C Ashe Jorunn L Helbostad Dawn A Skelton Source Type: research
Endovascular thrombectomy and intra-arterial interventions for acute ischaemic stroke
CONCLUSIONS: In individuals with acute ischaemic stroke due to large artery occlusion in the anterior circulation, endovascular thrombectomy can increase the chance of survival with a good functional outcome without increasing the risk of intracerebral haemorrhage or death.PMID:34125952 | DOI:10.1002/14651858.CD007574.pub3
Source: Cochrane Database of Systematic Reviews - June 14, 2021 Category: General Medicine Authors: Melinda B Roaldsen Mirza Jusufovic Eivind Berge Haakon Lindekleiv Source Type: research
Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia
CONCLUSIONS: High certainty randomised controlled trial evidence regarding the effect of hypertension treatment on dementia and cognitive decline does not yet exist. The studies included in this review provide low certainty evidence (downgraded primarily due to study limitations and indirectness) that pharmacological treatment of hypertension, in people without prior cerebrovascular disease, leads to less cognitive decline compared to controls. This difference is below the level considered clinically significant. The studies included in this review also provide very low certainty evidence that pharmacological treatment of ...
Source: Cochrane Database of Systematic Reviews - May 24, 2021 Category: General Medicine Authors: Emma L Cunningham Stephen A Todd Peter Passmore Roger Bullock Bernadette McGuinness Source Type: research
Anticoagulation versus placebo for heart failure in sinus rhythm
CONCLUSIONS: Based on the three RCTs, there is no evidence that oral anticoagulant therapy modifies mortality in people with HF in sinus rhythm. The evidence is uncertain if warfarin has any effect on all-cause death compared to placebo or no treatment, but it may increase the risk of major bleeding events. There is no evidence of a difference in the effect of rivaroxaban on all-cause death compared to placebo. It probably reduces the risk of stroke, but probably increases the risk of major bleedings. The available evidence does not support the routine use of anticoagulation in people with HF who remain in sinus rhythm.PMI...
Source: Cochrane Database of Systematic Reviews - May 18, 2021 Category: General Medicine Authors: Eduard Shantsila Monika Kozie ł Gregory Yh Lip Source Type: research
