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Source: Cochrane Database of Systematic Reviews
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Total 466 results found since Jan 2013.
Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage
CONCLUSIONS: The current evidence does not support the routine use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage. More specifically, early administration with concomitant treatment strategies to prevent delayed cerebral ischaemia does not improve clinical outcome. There is sufficient evidence from multiple randomised controlled trials to incorporate this conclusion in treatment guidelines.PMID:36350005 | DOI:10.1002/14651858.CD001245.pub3
Source: Cochrane Database of Systematic Reviews - November 9, 2022 Category: General Medicine Authors: Menno R Germans Wouter J Dronkers Merih I Baharoglu Ren é Post Dagmar Verbaan Gabriel Je Rinkel Yvo Bwem Roos Source Type: research
Interventions for perceptual disorders following stroke
CONCLUSIONS: Following a detailed, systematic search, we identified limited RCT evidence of the effectiveness of interventions for perceptual disorders following stroke. There is insufficient evidence to support or refute the suggestion that perceptual interventions are effective. More high-quality trials of interventions for perceptual disorders in stroke are needed. They should recruit sufficient participant numbers, include a 'usual care' comparison, and measure longer-term functional outcomes, at time points beyond the initial intervention period. People with impaired perception following a stroke should continue to re...
Source: Cochrane Database of Systematic Reviews - November 3, 2022 Category: General Medicine Authors: Christine Hazelton Katie Thomson Alex Todhunter-Brown Pauline Campbell Charlie Sy Chung Liam Dorris David C Gillespie Susan M Hunter Kris McGill Donald J Nicolson Linda J Williams Marian C Brady Source Type: research
Repetitive peripheral magnetic stimulation for impairment and disability in people after stroke
CONCLUSIONS: There is insufficient evidence to permit the drawing of any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to provide robust evidence for rPMS after stroke.PMID:36169558 | PMC:PMC9518012 | DOI:10.1002/14651858.CD011968.pub4
Source: Cochrane Database of Systematic Reviews - September 28, 2022 Category: General Medicine Authors: Tomohiko Kamo Yoshitaka Wada Masatsugu Okamura Kotomi Sakai Ryo Momosaki Shunsuke Taito Source Type: research
Hydroxyurea (hydroxycarbamide) for sickle cell disease
CONCLUSIONS: There is evidence to suggest that hydroxyurea may be effective in decreasing the frequency of pain episodes and other acute complications in adults and children with sickle cell anaemia of HbSS or HbSβºthal genotypes and in preventing life-threatening neurological events in those with sickle cell anaemia at risk of primary stroke by maintaining transcranial Doppler velocities. However, there is still insufficient evidence on the long-term benefits of hydroxyurea, particularly with regard to preventing chronic complications of SCD, or recommending a standard dose or dose escalation to maximum tolerated dose. ...
Source: Cochrane Database of Systematic Reviews - September 1, 2022 Category: General Medicine Authors: Angela E Rankine-Mullings Sarah J Nevitt Source Type: research
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
CONCLUSIONS: HIF stabiliser management of anaemia had uncertain effects on CV death, fatigue, death (any cause), CV outcomes, and kidney failure compared to placebo or ESAs. Compared to placebo or ESAs, HIF stabiliser management of anaemia probably decreased the proportion of patients requiring blood transfusions, and probably increased the proportion of patients reaching the target Hb when compared to placebo.PMID:36005278 | DOI:10.1002/14651858.CD013751.pub2
Source: Cochrane Database of Systematic Reviews - August 25, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Allison Jaure Elisabeth M Hodson Marinella Ruospo Tess E Cooper Deirdre Hahn Valeria M Saglimbene Jonathan C Craig Giovanni Fm Strippoli Source Type: research
