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Source: Stroke
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Total 4002 results found since Jan 2013.
Hyperintense Plaque on Intracranial Vessel Wall Magnetic Resonance Imaging as a Predictor of Artery-to-Artery Embolic Infarction Clinical Sciences
Background and Purpose—The aim of the present study was to investigate atherosclerotic plaque characteristics in patients with artery-to-artery (A-to-A) embolic infarction by whole-brain high-resolution magnetic resonance imaging.Methods—Seventy-four patients (mean age, 54.7±12.1 years; 59 men) with recent stroke in the territory of middle cerebral artery because of intracranial atherosclerotic disease were prospectively enrolled. Whole-brain high-resolution magnetic resonance imaging was performed in all the patients both precontrast and postcontrast administration by using a 3-dimensional T1-weighted vessel wall mag...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Fang Wu, Haiqing Song, Qingfeng Ma, Jiayu Xiao, Tao Jiang, Xiaoqin Huang, Xiaoming Bi, Xiuhai Guo, Debiao Li, Qi Yang, Xunming Ji, Zhaoyang Fan, on behalf of the WISP Investigators† Tags: Atherosclerosis, Embolism, Vascular Disease Original Contributions Source Type: research
Boosted Tree Model Reforms Multimodal Magnetic Resonance Imaging Infarct Prediction in Acute Stroke Clinical Sciences
Background and Purpose—Stroke imaging is pivotal for diagnosis and stratification of patients with acute ischemic stroke to treatment. The potential of combining multimodal information into reliable estimates of outcome learning calls for robust machine learning techniques with high flexibility and accuracy. We applied the novel extreme gradient boosting algorithm for multimodal magnetic resonance imaging–based infarct prediction.Methods—In a retrospective analysis of 195 patients with acute ischemic stroke, fluid-attenuated inversion recovery, diffusion-weighted imaging, and 10 perfusion parameters were derived from...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Michelle Livne, Jens K. Boldsen, Irene K. Mikkelsen, Jochen B. Fiebach, Jan Sobesky, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research
Association of White Matter Hyperintensities With Short-Term Outcomes in Patients With Minor Cerebrovascular Events Clinical Sciences
Conclusions—Our data suggest that quantitative and qualitative WML assessments are highly correlated and comparable in TIA/minor stroke patients. WML burden is associated with short-term outcome of patients with good prestroke function in the presence of intracranial stenosis/occlusion.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Charlotte Zerna, Amy Y.X. Yu, Jayesh Modi, Shiel K. Patel, Jonathan I. Coulter, Eric E. Smith, Shelagh B. Coutts Tags: Cerebrovascular Disease/Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke Clinical Sciences
This study aimed to assess how the ischemic core measured by perfusion computed tomography (CTP) was affected by the delay and dispersion effect.Methods—Ischemic stroke patients having CTP performed within 6 hours of onset were included. The CTP data were processed twice, generating standard cerebral blood flow (sCBF) and delay- and dispersion-corrected CBF (ddCBF), respectively. Ischemic core measured by the sCBF and ddCBF was then compared at the relative threshold
Source: Stroke - March 26, 2018 Category: Neurology Authors: Longting Lin, Andrew Bivard, Timothy Kleinig, Neil J. Spratt, Christopher R. Levi, Qing Yang, Mark W. Parsons Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research
Thalamic Diaschisis in Acute Ischemic Stroke Clinical Sciences
Background and Purpose—Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, which does not directly affect the thalamus.Methods—One hundred twenty-four patients with middle cerebral artery infarction were selected from a prospectively acquired cohort of 1644 patients who underwent multiparametric computed tomography (CT), including CT perfusion for suspected stroke. Two blinded read...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Paul Reidler, Kolja M. Thierfelder, Matthias P. Fabritius, Wieland H. Sommer, Felix G. Meinel, Franziska Dorn, Frank A. Wollenweber, Marco Duering, Wolfgang G. Kunz Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research
Posttreatment National Institutes of Health Stroke Scale Is Superior to the Initial Score or Thrombolysis in Cerebral Ischemia for 3-Month Outcome Clinical Sciences
Background and Purpose—The majority of ischemic stroke patients receiving endovascular recanalization therapy (EVT) experience variable changes of neurological severities during the hyperacute period. We hypothesized that the National Institutes of Health Stroke Scale (NIHSS) score after EVT is a better prognostic factor compared with the initial NIHSS score or revascularization status.Methods—We identified 566 stroke patients who received EVT at Seoul National University Bundang Hospital between April 2008 and December 2015. We prospectively collected post-EVT NIHSS score, which was measured in the angiography suite b...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Han-Gil Jeong, Beom Joon Kim, Jay Chol Choi, Keun-Sik Hong, Mi Hwa Yang, Cheolkyu Jung, Moon-Ku Han, Hee-Joon Bae Tags: Ischemic Stroke Original Contributions Source Type: research
Ambulance Clinical Triage for Acute Stroke Treatment Clinical Sciences
Background and Purpose—Clinical triage scales for prehospital recognition of large vessel occlusion (LVO) are limited by low specificity when applied by paramedics. We created the 3-step ambulance clinical triage for acute stroke treatment (ACT-FAST) as the first algorithmic LVO identification tool, designed to improve specificity by recognizing only severe clinical syndromes and optimizing paramedic usability and reliability.Methods—The ACT-FAST algorithm consists of (1) unilateral arm drift to stretcher
Source: Stroke - March 26, 2018 Category: Neurology Authors: Henry Zhao, Lauren Pesavento, Skye Coote, Edrich Rodrigues, Patrick Salvaris, Karen Smith, Stephen Bernard, Michael Stephenson, Leonid Churilov, Nawaf Yassi, Stephen M. Davis, Bruce C.V. Campbell Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke Clinical Sciences
Conclusions—Compared with target mismatch patients, those with the malignant profile experience faster infarct growth and a steeper decline in the odds of functional independence, with longer delays between baseline imaging and reperfusion. However, this does not exclude the possibility of treatment benefit in patients with a malignant profile.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Jenny P. Tsai, Michael Mlynash, Soren Christensen, Stephanie Kemp, Sun Kim, Nishant K. Mishra, Christian Federau, Raul G. Nogueira, Tudor G. Jovin, Thomas G. Devlin, Naveed Akhtar, Dileep R. Yavagal, Roland Bammer, Matus Straka, Gregory Zaharchuk, Michael Tags: Revascularization, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Rescue Stenting for Failed Mechanical Thrombectomy in Acute Ischemic Stroke Clinical Sciences
Conclusions—RS was independently associated with good outcomes without increasing symptomatic intracranial hemorrhage or mortality. RS seemed considered in MT-failed internal carotid artery or middle cerebral artery M1 occlusion.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Yoonkyung Chang, Byung Moon Kim, Oh Young Bang, Jang-Hyun Baek, Ji Hoe Heo, Hyo Suk Nam, Young Dae Kim, Joonsang Yoo, Dong Joon Kim, Pyoung Jeon, Seung Kug Baik, Sang Hyun Suh, Kyung-Yul Lee, Hyo Sung Kwak, Hong Gee Roh, Young-Jun Lee, Sang Heum Kim, Chan Tags: Revascularization, Stent, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials Clinical Sciences
Conclusions—The UW-mRS as primary outcome does not capture individual variation in utility values and may reduce the statistical power of a randomized trial.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Simone A. Dijkland, Daphne C. Voormolen, Esmee Venema, Bob Roozenbeek, Suzanne Polinder, Juanita A. Haagsma, Daan Nieboer, Vicky Chalos, Albert J. Yoo, Jennifer Schreuders, Aad van der Lugt, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Wim H. van Zwam, Rober Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Improving Community Stroke Preparedness in the HHS (Hip-Hop Stroke) Randomized Clinical Trial Clinical Sciences
Background and Purpose—Deficiencies in stroke preparedness cause major delays to stroke thrombolysis, particularly among economically disadvantaged minorities. We evaluated the effectiveness of a stroke preparedness intervention delivered to preadolescent urban public school children on the stroke knowledge/preparedness of their parents.Methods—We recruited 3070 fourth through sixth graders and 1144 parents from 22 schools into a cluster randomized trial with schools randomized to the HHS (Hip-Hop Stroke) intervention or attentional control (nutrition classes). HHS is a 3-hour culturally tailored, theory-based, multime...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Olajide Williams, Ellyn Leighton-Herrmann Quinn, Jeanne Teresi, Joseph P. Eimicke, Jian Kong, Gbenga Ogedegbe, James Noble Tags: Primary Prevention, Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study) Clinical Sciences
Conclusions—In addition to clinically apparent AF, other evidence of abnormal atrial substrate is associated with subsequent ischemic stroke. This finding is consistent with the hypothesis that thromboembolism from the left atrium may occur in the setting of several different manifestations of atrial disease.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Hooman Kamel, Traci M. Bartz, Mitchell S.V. Elkind, Peter M. Okin, Evan L. Thacker, Kristen K. Patton, Phyllis K. Stein, Christopher R. deFilippi, Rebecca F. Gottesman, Susan R. Heckbert, Richard A. Kronmal, Elsayed Z. Soliman, W.T. Longstreth Jr Tags: Arrhythmias, Cardiomyopathy, Echocardiography, Electrocardiology (ECG), Ischemic Stroke Original Contributions Source Type: research
Risk Factors for Poststroke Cognitive Decline Clinical Sciences
Background and Purpose—Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors’ prestroke cognitive trajectories are uncertain.Methods—Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score
Source: Stroke - March 26, 2018 Category: Neurology Authors: Deborah A. Levine, Virginia G. Wadley, Kenneth M. Langa, Frederick W. Unverzagt, Mohammed U. Kabeto, Bruno Giordani, George Howard, Virginia J. Howard, Mary Cushman, Suzanne E. Judd, Andrzej T. Galecki Tags: Quality and Outcomes, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research
Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats Basic Sciences
This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined.Methods—Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Shenglong Cao, Ya Hua, Richard F. Keep, Neeraj Chaudhary, Guohua Xi Tags: Basic Science Research, Intracranial Hemorrhage Original Contributions Source Type: research
Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion Basic Sciences
Conclusions—Factors secreted by EPCs may ameliorate white matter damage in the brain by boosting oligovascular remodeling.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Takakuni Maki, Anna Morancho, Pablo Martinez–San Segundo, Kazuhide Hayakawa, Haȷime Takase, Anna C. Liang, Marina Gabriel–Salazar, Esperanza Medina–Gutierrez, Kazuo Washida, Joan Montaner, Josephine Lok, Eng H. Lo, Ken Arai, Anna Tags: Angiogenesis, Animal Models of Human Disease, Basic Science Research, Cell Therapy, Growth Factors/Cytokines Original Contributions Source Type: research
